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Anti-apolipoprotein A-1 antibodies and carotid intima–media thickness in Egyptian women with systemic lupus erythematosus

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Abstract

The objective of the study was to evaluate anti-apolipoprotein A-I (Apo A-I) and carotid intima–media thickness (cIMT) as cardiovascular risk factors in Egyptian women with systemic lupus erythematosus (SLE). The study included 160 subjects, 80 women with SLE and 80 healthy women as a control group. Disease activity score (SLEDAI), disease damage index (SLICC/ACR), lipid profile, complement C3 and C4, high-sensitivity CRP (hsCRP), anti-dsDNA and anticardiolipin antibodies were evaluated in addition to anti-Apo A-I antibodies and cIMT. The mean age of patients was 28.35 ± 7.06 years with mean disease duration of 4.58 ± 3.36 years. Anti-Apo A-I antibody titer was significantly higher in SLE patients than in controls (mean 35.3 ± 6.8 vs. 21.4 ± 5.91 U/L; P = 0.000). Carotid ultrasound showed significantly thickened intima in SLE patients compared with control subjects (mean thickness, 0.5 ± 0.08 vs. 0.45 ± 0.06 mm; P = 0.003). Correlation studies with other cardiovascular risk factors demonstrated significant associations between anti-Apo A-I and SLEDAI, SLICC/ACR, C3 and C4. On the other hand, cIMT showed significant association with age, systolic blood pressure, hsCRP and body mass index. Thus, SLE disease activity is associated with a significant increase in anti-Apo A-I titer. Also, increased cIMT might be a cardiovascular risk factor in Egyptian patients with SLE.

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Conflict of interest

All authors certify that there are no conflicts of interest of this manuscript with any party.

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Authors and Affiliations

  1. Department of Internal Medicine, National Research Centre, Cairo, Egypt

    M. M. Radwan

  2. Department of Clinical Pathology, National Research Centre, Al-Bohouth street, Cairo, Egypt

    D. El-Lebedy

  3. Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt

    R. Fouda

  4. Department of Rheumatology, Faculty of Medicine, Cairo University, Cairo, Egypt

    E. Elsorougy

  5. Department of Medical Biochemistry, National Research Centre, Cairo, Egypt

    D. Fakhry

Authors
  1. M. M. Radwan
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  2. D. El-Lebedy
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  3. R. Fouda
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  4. E. Elsorougy
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  5. D. Fakhry
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Correspondence to D. El-Lebedy.

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Radwan, M.M., El-Lebedy, D., Fouda, R. et al. Anti-apolipoprotein A-1 antibodies and carotid intima–media thickness in Egyptian women with systemic lupus erythematosus. Clin Rheumatol 33, 493–498 (2014). https://doi.org/10.1007/s10067-013-2399-8

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  • DOI: https://doi.org/10.1007/s10067-013-2399-8

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