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A simplified version of Ankylosing Spondylitis Disease Activity Score (ASDAS) in patients with ankylosing spondylitis

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Abstract

This study aimed to develop a simplified version of the Ankylosing Spondylitis Disease Activity Score (ASDAS). The study included consecutive patients with ankylosing spondylitis according to modified New York and/or Assessment in Ankylosing Spondylitis 2009 criteria. Sociodemographic data and characteristics of the disease (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), and Ankylosing Spondylitis Quality of Life (ASQoL)) and erythrocyte sedimentation rate (ESR) were collected. ASDAS simplified version (SASDAS) was calculated as the simple linear sum of the five components of ASDAS which include: patient global assessment using visual analogue scale, back pain (BASDAI question no. 2), peripheral pain and swelling (BASDAI question no. 3), morning stiffness (BASDAI question no. 6), and ESR in millimeters per hour, divided by 10 so as to make it equivalent to the other scale's components. Eighty-six patients were included: 69 (80.2 %) were men with a median age of 46 years and median disease duration of 19 years. SASDAS showed an excellent correlation with the ASDAS (r = 0.93). SASDAS also showed a good correlation with night pain (r = 0.60), global pain (r = 0.69), ASQoL (r = 0.70), BASFI (r = 0.75), and BASDAI (r = 0.96). Using ASDAS cut-off values previously suggested, the corresponding cut-off values for SASDAS were as follows: from 0 to 7.8 (inactive disease), from 7.9 to 13.8 (moderate disease activity), from 13.9 to 27.6 (high disease activity), and above 27.6 (very high disease activity) with optimum sensitivity and specificity. SASDAS showed an excellent correlation with conventional clinical measures of disease activity, and it can be easily calculated and is simple to use in daily clinical practice.

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References

  1. González-Roces S, Alvarez V (1996) HLA-B27 structure, function, and disease association. Curr Opin Rheumatol 8(4):296–308

    Article  PubMed  Google Scholar 

  2. Gran JT, Skomsvoll JF (1997) The outcome of ankylosing spondylitis: a study of 100 patients. Br J Rheumatol 24:908–911

    Google Scholar 

  3. van der Linden S, van der Heijde D (1998) Ankylosing spondylitis. Clinical features. Rheum Dis Clin North Am 24:663–673

    Article  PubMed  Google Scholar 

  4. Hammer RE, Maika SD, Richardson JA (1990) Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders. Cell 63(5):1099–1112

    Article  PubMed  CAS  Google Scholar 

  5. Dalyan M, Guner A, Tuncer S, BilgiÇ A, Arasil T (1999) Disability in ankylosing spondylitis. Disabil Rehabil 21:74–79

    Article  PubMed  CAS  Google Scholar 

  6. Masi AT, Walsh EG (2003) Ankylosing spondylitis: integrated clinical and physiological perspectives. Clin Exp Rheumatol 21:1–8

    PubMed  CAS  Google Scholar 

  7. Marengo MF, Schneeberger EE, Citera G, Maldonado Cocco JA (2008) Work status among patients with ankylosing spondylitis in Argentina. J Clin Rheumatol 14:273–277

    Article  PubMed  Google Scholar 

  8. Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A (1994) A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 21:2286–2291

    PubMed  CAS  Google Scholar 

  9. Lukas C, Landewé R, Sieper J et al (2009) Development of an ASAS-endorsed disease activity score (ASDAS) in patient with ankylosing spondylitis. Ann Rheum Dis 68:18–24

    Article  PubMed  CAS  Google Scholar 

  10. Pedersen SJ, Sorensen IJ, Hermann KG et al (2010) Responsiveness of the Ankylosing Spondylitis Disease Activity Score (ASDAS) and clinical and MRI measures of disease activity in a 1-year follow-up study of patients with axial spondyloarthritis treated with tumour necrosis factor alpha inhibitors. Ann Rheum Dis 69:1065–1071

    Article  PubMed  Google Scholar 

  11. Nas K, Yildirim K, Cevik R et al (2010) Discrimination ability of ASDAS estimating disease activity status in patient with ankylosing spondylitis. Inter J Rheum Dis 13:240–245

    Article  Google Scholar 

  12. Smolen JS, Breedveld FC, Schiff MH, Kalden JR, Emery P, Eberl G (2003) A simplified disease activity index for rheumatoid arthritis for use in clinical practice. Rheumatology 42:244–257

    Article  PubMed  CAS  Google Scholar 

  13. Machado P, Landewé R, Lie E et al (2011) Ankylosing Spondylitis Disease Activity Score (ASDAS): defining cut-off values for disease activity states and improvement scores. Ann Rheum Dis 70:47–53

    Article  PubMed  Google Scholar 

  14. van der Linden S, Valkenburg HA, Cats A (1984) Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for the modification of the New York criteria. Arthritis Rheum 27:361–368

    Article  PubMed  Google Scholar 

  15. Sieper J, van der Heijde D, Landewé R et al (2009) New criteria for inflammatory back pain in patients with chronic back pain: a real patient exercise by experts from the Assessment of Spondyloarthritis international Society (ASAS). Ann Rheum Dis 68:784–788

    Article  PubMed  CAS  Google Scholar 

  16. Doward L, Spoorerg A, Cook S et al (2003) Development of the ASQoL: a quality of life instrument specific to ankylosing spondylitis. Ann Rheum Dis 62:20–26

    Article  PubMed  CAS  Google Scholar 

  17. Calin A, Garrett SL, Whitelock H, Kennedy LG, O’Hea J, Mallorie P et al (1994) A new approach to functional ability in ankylosing spondylitis: the Bath Ankylosing Spondylitis Functional Index. J Rheumatol 21:2281–2285

    PubMed  CAS  Google Scholar 

  18. Citera G, Maldonado Cocco J, Moroldo M, Burgos-Vargas R, Anaya J, López I, Gutiérrez M (1999) Validación de la versión en español de los cuestionarios de capacidad funcional (BASFI) y actividad de la enfermedad (BASDAI) en pacientes con Espondilitis Anquilosante en cuatro países latinoamericanos. Rev Argent Reumatol 10(Supl 1):25 [abstract]

    Google Scholar 

  19. Buschiazzo E, Sommerfleck F, Schneeberger EE, Arturi P, Maldonado Cocco JA, Citera G (2010) Validación del índice ASDAS en una cohorte de pacientes con Espondilitis Anquilosante. Rev Arg Reumatol 21:28

    Google Scholar 

  20. Aydin SZ, Can M, Atagunduz P et al (2010) Active disease requiring TNF-alpha antagonist therapy can be well discriminated with different ASDAS sets: a prospective, follow-up of disease activity assessment in ankylosing spondylitis. Clin Exp Rheumatol 28:752–755

    PubMed  CAS  Google Scholar 

  21. Eder L, Chandran V, Shen H et al (2010) Is ASDAS better than BASDAI as a measure of disease activity in axial psoriatic arthritis? Ann Rheum Dis 69:2160–2164

    Article  PubMed  Google Scholar 

  22. Machado P, van der Heijde D (2011) How to measure disease activity in axial spondyloarthritis? Curr Opin Rheumatol 23:339–345

    Article  PubMed  Google Scholar 

  23. Curet AV, Rillo OL, Chaparro del Moral RE, Papasidero SB, Citera G, Maldonado Cocco JA et al (2005) Modificación y aplicación de un índice de actividad simplificado (IAS) en pacientes con Artritis Reumatoidea. Rev Argent Reumatol Suppl 1:13

    Google Scholar 

  24. Aletaha D, Smolen J (2005) The Simplified Disease Activity Index (SDAI) and the Clinical Disease Activity Index (CDAI): a review of their usefulness and validity in rheumatoid arthritis. Clin Exp Rheumatol 23:100–108

    Google Scholar 

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Authors and Affiliations

  1. Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Echeverría 955, 1428, Buenos Aires, Argentina

    Fernando A. Sommerfleck, Emilce E. Schneeberger, Emilio E. Buschiazzo, José A. Maldonado Cocco & Gustavo Citera

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  1. Fernando A. Sommerfleck
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  2. Emilce E. Schneeberger
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  3. Emilio E. Buschiazzo
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  4. José A. Maldonado Cocco
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  5. Gustavo Citera
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Correspondence to Gustavo Citera.

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Sommerfleck, F.A., Schneeberger, E.E., Buschiazzo, E.E. et al. A simplified version of Ankylosing Spondylitis Disease Activity Score (ASDAS) in patients with ankylosing spondylitis. Clin Rheumatol 31, 1599–1603 (2012). https://doi.org/10.1007/s10067-012-2056-7

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  • DOI: https://doi.org/10.1007/s10067-012-2056-7

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