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Periodic fever as the manifestation of primary Sjogren’s syndrome: a case report and literature review

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Abstract

A 56-year-old male had periodic fever for 5 years and suffered from auditory hallucination and hearing impairment for 3 years. Xerostomia, xerophthalmia, elevated anti-SSA/Ro tilter, positive Schirmer’s test, and lymphocyte infiltrate of mucoserous gland in lip biopsy of this case confirmed the diagnosis of primary Sjogren’s syndrome (pSS). We review literature for fever and neuropsychiatric involvement in pSS case series. Though fever is present in 6–41 % pSS cases, periodic fever has not been reported. Auditory hallucination was rare in cases with pSS. The literature review alerts clinicians that fever and neurological manifestations were not uncommon in pSS cases.

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Authors and Affiliations

  1. Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Tzyou 1st Road 807, Kaohsiung, Taiwan, China

    Hui-Ching Wang, Chun-Yu Lin, Yen-Hsu Chen & Po-Liang Lu

  2. Department of Internal Medicine, Kaohsiung Municipal Hsaio-Kang Hospital, Kaohsiung, Taiwan, China

    Ko Chang

  3. Graduate Institute of Medicine, Tropical Medicine Research Center, Kaohsiung, Taiwan, China

    Yen-Hsu Chen

  4. Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, China

    Po-Liang Lu

  5. College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, China

    Po-Liang Lu

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  1. Hui-Ching Wang
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  2. Ko Chang
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  3. Chun-Yu Lin
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  4. Yen-Hsu Chen
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Correspondence to Po-Liang Lu.

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Wang, HC., Chang, K., Lin, CY. et al. Periodic fever as the manifestation of primary Sjogren’s syndrome: a case report and literature review. Clin Rheumatol 31, 1517–1519 (2012). https://doi.org/10.1007/s10067-012-2039-8

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  • DOI: https://doi.org/10.1007/s10067-012-2039-8

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