Abstract
Rheumatic diseases as well as inflammatory bowel disease (IBD) have been associated with the occurrence of non-cystic fibrosis bronchiectasis (NCFB). There are few data on NCFB and adverse events from immunosuppressive or biological response modifier therapy in patients with rheumatoid arthritis (RA) or IBD and NCFB. We identified 37 patients with NCFB and rheumatic disease, and nine patients with inflammatory bowel disease that received immunomodulatory treatment. We retrospectively analysed adverse pulmonary events. In nine patients with RA, the association between disease activity score (DAS) and spirometry was analysed in a small cohort study. Pulmonary side effects occurred in 50% of patients, most commonly respiratory infections, and resulted in a change of immunomodulatory treatment in 37% of patients. Spirometry and exacerbation rate was not different in NCFB patients with RA or IBD as compared with NFCB due to other causes. The incidence of pulmonary adverse events was highest in patients treated with conventional immunomodulatory treatment, especially methotrexate, as compared with patients with NCFB treated with newer biological therapies. Three patients were started on azithromycin because of recurrent bronchitis and had no events afterwards. Serial assessment of DAS and spirometry showed that a rise in DAS was associated with lung function decline and vice versa. Currently used immunosuppressive drugs can be used in NCFB albeit under close follow-up. The role of azithromycin for infection prevention needs further research. An association between DAS and lung function was shown.
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Abbreviations
- AS:
-
Ankylosing spondylitis
- DAS:
-
Disease activity score
- FEF25-75% :
-
Forced expiratory flow 25–75%
- FEV1 :
-
Forced expiratory volume in 1 s
- FVC:
-
Forced vital capacity
- HRCT:
-
High-resolution computed tomography
- IBD:
-
Inflammatory bowel disease
- NCFB:
-
Non-cystic fibrosis bronchiectasis
- RA:
-
Rheumatoid arthritis
- SLE:
-
Systemic lupus erythematosus
- UC:
-
Ulcerative colitis
References
Cohen M, Sahn SA (1999) Bronchiectasis in systemic diseases. Chest 116(4):1063–1074
Kozuka T, Johkoh T, Honda O, Mihara N, Koyama M, Tomiyama N et al (2001) Pulmonary involvement in mixed connective tissue disease: high-resolution CT findings in 41 patients. J Thorac Imaging 16(2):94–98
Andonopoulos AP, Yarmenitis S, Georgiou P, Bounas A, Vlahanastasi C (2001) Bronchiectasis in systemic sclerosis. A study using high resolution computed tomography. Clin Exp Rheumatol 19(2):187–190
Cortet B, Flipo RM, Remy-Jardin M, Coquerelle P, Duquesnoy B, Remy J et al (1995) Use of high resolution computed tomography of the lungs in patients with rheumatoid arthritis. Ann Rheum Dis 54(10):815–819
Hassan WU, Keaney NP, Holland CD, Kelly CA (1995) High resolution computed tomography of the lung in lifelong non-smoking patients with rheumatoid arthritis. Ann Rheum Dis 54(4):308–310
Shi JH, Liu HR, Xu WB, Feng RE, Zhang ZH, Tian XL et al (2009) Pulmonary manifestations of Sjogren's syndrome. Respiration 78:377–386
Casserly IP, Fenlon HM, Breatnach E, Sant SM (1997) Lung findings on high-resolution computed tomography in idiopathic ankylosing spondylitis—correlation with clinical findings, pulmonary function testing and plain radiography. Br J Rheumatol 36(6):677–682
Fenlon HM, Doran M, Sant SM, Breatnach E (1996) High-resolution chest CT in systemic lupus erythematosus. AJR Am J Roentgenol 166(2):301–307
El MA, Chaouir S, Abid A, Bezza A, Tabache F, Achemlal L et al (2004) Lung findings on thoracic high-resolution computed tomography in patients with ankylosing spondylitis. Correlations with disease duration, clinical findings and pulmonary function testing. Clin Rheumatol 23(2):123–128
Swinson DR, Symmons D, Suresh U, Jones M, Booth J (1997) Decreased survival in patients with co-existent rheumatoid arthritis and bronchiectasis. Br J Rheumatol 36(6):689–691
Raj AA, Birring SS, Green R, Grant A, de CJ, Pavord ID (2008) Prevalence of inflammatory bowel disease in patients with airways disease. Respir Med 102(5):780–785
Black H, Mendoza M, Murin S (2007) Thoracic manifestations of inflammatory bowel disease. Chest 131(2):524–532
Lieberman-Maran L, Orzano IM, Passero MA, Lally EV (2006) Bronchiectasis in rheumatoid arthritis: report of four cases and a review of the literature—implications for management with biologic response modifiers. Semin Arthritis Rheum 35(6):379–387
Bhalla M, Turcios N, Aponte V, Jenkins M, Leitman BS, McCauley DI et al (1991) Cystic fibrosis: scoring system with thin-section CT. Radiology 179(3):783–788
Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA et al (1981) A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 30(2):239–245
Goeminne P, Dupont L (2010) Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st century. Postgrad Med J 86(1018):493–501
Anwar GA, Bourke SC, Afolabi G, Middleton P, Ward C, Rutherford RM (2008) Effects of long-term low-dose azithromycin in patients with non-CF bronchiectasis. Respir Med 102(10):1494–1496
Cymbala AA, Edmonds LC, Bauer MA, Jederlinic PJ, May JJ, Victory JM et al (2005) The disease-modifying effects of twice-weekly oral azithromycin in patients with bronchiectasis. Treat Respir Med 4(2):117–212
Tsang KW, Ho PI, Chan KN, Ip MS, Lam WK, Ho CS et al (1999) A pilot study of low-dose erythromycin in bronchiectasis. Eur Respir J 13(2):361–364
Bruyn GA, Jansen TL, Ten Brinke A, De Vries M, Houtman PM, van Roon EN (2007) Cavitating pneumonia, a severe complication of leflunomide therapy in chronic polyarthritis. Rheumatology 46(3):553–554
Chikura B, Lane S, Dawson JK (2009) Clinical expression of leflunomide-induced pneumonitis. Rheumatology 48(9):1065–1068
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Goeminne, P.C., Verschueren, P., Scheers, H. et al. Safety of immunomodulatory therapy in patients with bronchiectasis associated with rheumatic disease and IBD: a retrospective and cohort analysis. Clin Rheumatol 31, 367–373 (2012). https://doi.org/10.1007/s10067-011-1849-4
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DOI: https://doi.org/10.1007/s10067-011-1849-4