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P-wave dispersion in systemic AA amyloidosis of familial Mediterranean fever

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Abstract

Familial Mediterranean fever (FMF) is a hereditary disease characterized by attacks of fever and polyserositis. Recent studies differ as to whether FMF is associated with an abnormally high P-wave duration and P-wave dispersion, markers for supraventricular arrhythmogenicity. The aim of our study was to further evaluate atrial dispersion in FMF patients with amyloidosis. The study groups consisted of 16 patients with FMF and amyloidosis, and 16 age- and sex-matched control subjects. All participants underwent 12-lead electrocardiography under strict standards. P-wave length and P-wave dispersion in each individual patient were computed from a randomly selected beat and an averaged beat constructed from 7 to 12 beats, included in a 10-s electrocardiogram. No statistically significant differences were found between the groups for minimal, maximal, and average P-wave duration and P-wave dispersion, calculated either from a random beat or averaged beats. In conclusion, although a small difference cannot be excluded because of the small study groups, FMF patients with amyloidosis appear to have atrial conduction parameters similar to those of healthy controls, and therefore apparently do not have an increased electrocardiographic risk for developing supraventricular arrhythmias.

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References

  1. Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T, Migdal A, Padeh S, Pras M (1997) Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 40(10):1879–1885

    Article  PubMed  CAS  Google Scholar 

  2. Gershoni-Baruch R, Brik R, Zacks N, Shinawi M, Lidar M, Livneh A (2003) The contribution of genotypes at the MEFV and SAA1 loci to amyloidosis and disease severity in patients with familial Mediterranean fever. Arthritis Rheum 48(4):1149–1155

    Article  PubMed  Google Scholar 

  3. Touitou I, Sarkisian T, Medlej-Hashim M, Tunca M, Livneh A, Cattan D, Yalcinkaya F, Ozen S, Majeed H, Ozdogan H, Kastner D, Booth D, Ben-Chetrit E, Pugnere D, Michelon C, Seguret F, Gershoni-Baruch R (2007) Country as the primary risk factor for renal amyloidosis in familial Mediterranean fever. Arthritis Rheum 56(5):1706–1712

    Article  PubMed  Google Scholar 

  4. Lidar M, Zandman-Goddard G, Shinar Y, Zaks N, Livneh A, Langevitz P (2008) Systemic lupus erythematosus and familial Mediterranean fever: a possible negative association between the two disease entities–report of four cases and review of the literature. Lupus 17(7):663–669

    Article  PubMed  CAS  Google Scholar 

  5. Livneh A, Langevitz P (2000) Diagnostic and treatment concerns in familial Mediterranean fever. Baillières Best Pract Res Clin Rheumatol 14(3):477–498

    Article  PubMed  CAS  Google Scholar 

  6. Sari I, Karaoglu O, Can G, Akar S, Gulcu A, Birlik M, Akkoc N, Tunca M, Goktay Y, Onen F (2007) Early ultrasonographic markers of atherosclerosis in patients with familial Mediterranean fever. Clin Rheumatol 26(9):1467–1473

    Article  PubMed  Google Scholar 

  7. Akdogan A, Calguneri M, Yavuz B, Arslan EB, Kalyoncu U, Sahiner L, Karadag O, Ertenli I, Kiraz S, Aytemir K, Akata D, Tokgozoglu L, Oto A (2006) Are familial Mediterranean fever (FMF) patients at increased risk for atherosclerosis? Impaired endothelial function and increased intima media thickness are found in FMF. J Am Coll Cardiol 48(11):2351–2353

    Article  PubMed  Google Scholar 

  8. Gasparyan AY, Ugurlucan M (2008) The emerging issue of cardiovascular involvement in familial Mediterranean fever. Arch Med Sci 4(4):465–467

    Google Scholar 

  9. Akcay A, Acar G, Sayarlioglu M, Sokmen A, Kaya H, Ispiroglu M, Koroglu S (2009) QT dispersion and transmural dispersion of repolarization in patients with familial Mediterranean fever. Mod Rheumatol 19:550–555

    Article  PubMed  Google Scholar 

  10. Nussinovitch N, Livneh A, Katz K, Langevitz P, Feld O, Nussinovitch M, Volovitz B, Lidar M, Nussinovitch U (2010) QT dispersion in uncomplicated familial Mediterranean fever. Clin Rheumatol 29:1353–1356

    Article  PubMed  Google Scholar 

  11. Nussinovitch N, Livneh A, Katz K, Langevitz P, Feld O, Nussinovitch M, Volovitz B, Lidar M, Nussinovitch U (2011) Heart rate variability in familial Mediterranean fever. Rheumatol Int 31(1):39–43

    Article  PubMed  Google Scholar 

  12. Rozenbaum M, Naschitz JE, Yudashkin M, Rosner I, Sabo E, Shaviv N, Gaitini L, Zuckerman E, Yeshurun D (2002) Cardiovascular autonomic dysfunction in familial Mediterranean fever. J Rheumatol 29(5):987–989

    PubMed  Google Scholar 

  13. Michelucci A, Bagliani G, Colella A, Pieragnoli P, Porciani MC, Gensini G, Padeletti L (2002) P wave assessment: state of the art update. Card Electrophysiol Rev 6(3):215–220

    Article  PubMed  Google Scholar 

  14. Acar G, Akcay A, Sayarlioglu M, Sokmen A, Sokmen G, Koroglu S, Gunduz M, Ispiroglu M, Tuncer C (2009) Assessment of atrial conduction time in patients with familial Mediterranean fever. Pacing Clin Electrophysiol 32(3):308–313

    Article  PubMed  Google Scholar 

  15. Nussinovitch N, Livneh A, Katz K, Nussinovitch M, Volovitz B, Lidar M, Nussinovitch U (2011) P wave dispersion in familial Mediterranean fever. Rheumatol Int (in press)

  16. Kose S, Aytemir K, Can I, Iyisoy A, Kilic A, Amasyali B, Kursaklioglu H, Isik E, Oto A, Demirtas E (2002) Seasonal variation of P-wave dispersion in healthy subjects. J Electrocardiol 35(4):307–311

    Article  PubMed  Google Scholar 

  17. Scheinman MM (2000) Mechanisms of atrial fibrillation: is a cure at hand? J Am Coll Cardiol 35(6):1687–1692

    Article  PubMed  CAS  Google Scholar 

  18. Abidov A, Hachamovitch R, Rozanski A, Hayes SW, Santos MM, Sciammarella MG, Cohen I, Gerlach J, Friedman JD, Germano G, Berman DS (2004) Prognostic implications of atrial fibrillation in patients undergoing myocardial perfusion single-photon emission computed tomography. J Am Coll Cardiol 44(5):1062–1070

    Article  PubMed  Google Scholar 

  19. Dhoble A, Khasnis A, Olomu A, Thakur R (2009) Cardiac amyloidosis treated with an implantable cardioverter defibrillator and subcutaneous array lead system: report of a case and literature review. Clin Cardiol 32(8):E63–E65

    Article  PubMed  Google Scholar 

  20. Comenzo RL (2000) Primary systemic amyloidosis. Curr Treat Options Oncol 1(1):83–89

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

We thank Phyllis Curchack Kornspan for her editorial assistance. This study is dedicated in memory of Haim Gueron.

Disclosures

None.

Author information

Authors and Affiliations

  1. The Heller Institute of Medical Research and Department of Medicine F, Sheba Medical Center, Tel Hashomer, Israel

    Udi Nussinovitch, Avi Livneh, Ilan Ben-Zvi & Merav Lidar

  2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Udi Nussinovitch, Avi Livneh, Moshe Nussinovitch, Benjamin Volovitz, Ilan Ben-Zvi, Merav Lidar & Naomi Nussinovitch

  3. Department of Pediatrics C, Schneider Children’s Medical Center of Israel, Petach Tikva, Israel

    Moshe Nussinovitch & Benjamin Volovitz

  4. Hypertension Unit and Department of Internal Medicine D, Sheba Medical Center, Tel Hashomer, Israel

    Naomi Nussinovitch

Authors
  1. Udi Nussinovitch
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  2. Avi Livneh
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  3. Moshe Nussinovitch
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  4. Benjamin Volovitz
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  5. Ilan Ben-Zvi
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  6. Merav Lidar
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  7. Naomi Nussinovitch
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Corresponding author

Correspondence to Udi Nussinovitch.

Additional information

Udi Nussinovitch and Avi Livneh, the first two authors, have contributed equally to this work.

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Nussinovitch, U., Livneh, A., Nussinovitch, M. et al. P-wave dispersion in systemic AA amyloidosis of familial Mediterranean fever. Clin Rheumatol 30, 1295–1298 (2011). https://doi.org/10.1007/s10067-011-1745-y

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  • DOI: https://doi.org/10.1007/s10067-011-1745-y

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