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Wasabi nose: an underreported complication of cyclophosphamide infusions

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Abstract

Wasabi nose, a term used to describe the nasopharyngeal discomfort experienced during cyclophosphamide infusions, is a rare phenomenon, previously described in case reports of adult oncology patients typically receiving high-dose chemotherapy regimens. The underlying mechanism by which this phenomenon occurs is unknown. We report four cases of children with rheumatic diseases afflicted by profound nasopharyngeal discomfort secondary to low-dose cyclophosphamide infusions. We additionally review the literature regarding potential medical management of these complications and describe our experience using these interventions.

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  1. Department of Pediatrics, Division of Rheumatology, Children’s Hospital at Montefiore, 3415 Bainbridge Avenue, Bronx, New York, NY, 10463, USA

    Ginger L. Janow, Norman T. Ilowite & Dawn M. Wahezi

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  1. Ginger L. Janow
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  2. Norman T. Ilowite
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  3. Dawn M. Wahezi
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Correspondence to Dawn M. Wahezi.

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Janow, G.L., Ilowite, N.T. & Wahezi, D.M. Wasabi nose: an underreported complication of cyclophosphamide infusions. Clin Rheumatol 30, 1003–1005 (2011). https://doi.org/10.1007/s10067-011-1728-z

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  • DOI: https://doi.org/10.1007/s10067-011-1728-z

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