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Relapsing polychondritis and familial Mediterranean fever—an association

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Abstract

Relapsing polychondritis (RP) and familial Mediterranean fever (FMF) are systemic inflammatory disorders with seemingly distinct genetic and pathophysiologic mechanisms. An association between these disorders has been described based on a single case report with few clinical details available. We recently encountered a patient with biopsy-proven RP and genetically confirmed FMF. Following identification of this individual, we conducted a retrospective review of all cases of RP in our institution from 2000–2009 and identified one additional patient with RP who is also a genetic heterozygote for FMF. These cases highlight the previously reported but sparsely documented relationship between these seemingly separate disorders.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine “D”, Kaplan Medical Center affiliated with the Hebrew University School of Medicine, POB 1, Rehovot, Israel, 76100

    Edward B. Miller

  2. Division of Rheumatology, Department of Internal Medicine “A”, Kaplan Medical Center affiliated with the Hebrew University School of Medicine, Rehovot, Israel

    Joshua A. Friedman

  3. Department of Otolaryngology, Kaplan Medical Center affiliated with the Hebrew University School of Medicine, Rehovot, Israel

    Yonatan Lahav

  4. Department of Internal Medicine “D”, Kaplan Medical Center affiliated with the Hebrew University School of Medicine, POB 1, Rehovot, Israel, 76100

    Zvi Landau

Authors
  1. Edward B. Miller
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  2. Joshua A. Friedman
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  3. Yonatan Lahav
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  4. Zvi Landau
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Correspondence to Edward B. Miller.

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Miller, E.B., Friedman, J.A., Lahav, Y. et al. Relapsing polychondritis and familial Mediterranean fever—an association. Clin Rheumatol 30, 711–713 (2011). https://doi.org/10.1007/s10067-010-1673-2

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  • DOI: https://doi.org/10.1007/s10067-010-1673-2

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