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MRI findings of neuro-Behcet’s disease

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Abstract

Neurological manifestations present in 5% to 30% of patients with Behçet’s disease. We studied consecutive patients with relapsing–remitting or progressive neuro-Behcet’s disease who referred from January 2002 to January 2009 to Nemazee Hospital, Shiraz, southern Iran. Sequential MRIs were performed during clinical relapses in patients with relapsing–remitting course or during relentless progression after first referral of patients with progressive course. We reviewed 55 MRIs of 17 patients (ten men and seven women) with age of 36.4 ± 8.1 years at the time of first MRI. Nine (53%) patients had a relapsing–remitting course and eight (47%) had a progressive course. The initial and last follow-up studies had a mean interval of 29.2 months (range, 24 to 84). Of the patients with progressive neuro-Behcet’s disease, 50% had brainstem atrophy and 75% had black holes in their last follow-up MRIs. The respective prevalence rates for those with relapsing–remitting neuro-Behcet’s disease were 0% and 11%. In the total population of patients with neuro-Behcet’s disease, the number of lesions (p = 0.002) and MRI burden (p = 0.016) had a significant increase in the last follow-up studies in comparison to the initial studies. Incremental pattern in the number of lesions and MRI burdens in patients with parenchymal neuro-Behcet’s disease in our longitudinal study may imply an ongoing pathologic process.

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References

  1. Borhani Haghighi A, Pourmand R, Nikseresht AR (2005) Neuro-Behçet’s disease: a review. The Neurologist 11:80–89

    Article  PubMed  Google Scholar 

  2. Borhani Haghighi A, Samangooei S, Ashjazadeh N et al (2006) Neurological manifestation of Behçet’s disease. Saudi Med J 27:1542–1546

    Google Scholar 

  3. Tali ET, Atilla S, Keskin T, Simonson T, Isik S, Yuh WT (1997) MRI in neuro-Behçet’s disease. Neuroradiology 39:2–6

    Article  PubMed  CAS  Google Scholar 

  4. Kocer N, Islak C, Siva A, Saip S, Akman C, Kantarci O, Hamuryudan V (1999) CNS involvement in Neuro–Behçet’s syndrome: an MR study. Am J Neuroradol 20:1015–1024

    CAS  Google Scholar 

  5. Lee HS, Pyeong HY, Sang JP, Dong IK (2001) MRI Findings in Neuro-Behçet’s Disease. Clin Radiol 56:485–494

    Article  Google Scholar 

  6. Akman-Demir G, Bahar S, Coban O, Tasci B, Serdaroglu P (2003) Cranial MRI in Behçet’s disease: 134 examinations of 98 patients. Neuroradiology 45:851–859

    Article  PubMed  CAS  Google Scholar 

  7. Gerber S, Biondi A, Dormont D, Wechsler B, Marsault C (1998) Long-term MR follow-up of cerebral lesions in neuro-Behçet’s disease. Neuroradiology 38:761–768

    Article  Google Scholar 

  8. Morrissey SP, Miller DH, Hermaszewski R et al (1993) Magnetic resonance imaging of the central nervous system in Behçet’s Disease. Eur Neurol 33:287–293

    Article  PubMed  CAS  Google Scholar 

  9. Nussel F, Wegmuller H, Laseyras F et al (1991) Neuro-Behçet’s: acute and sequential aspects by MRI and MRS. Eur Neurol 31:399–402

    Article  PubMed  CAS  Google Scholar 

  10. International Study Group for Behçet’s Disease (1990) Criteria for diagnosis of Behçet’s disease. Lancet 335:1078–1080

    Google Scholar 

  11. McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD et al (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 50:121–127

    Article  PubMed  CAS  Google Scholar 

  12. Borhani Haghighi A (2008) Comment on “histopathology of central nervous system lesions in Behcet’s disease”. J Neurol Sci 270(1–2):211

    Article  PubMed  Google Scholar 

  13. Akman-Demir G, Tuzun E, Icoz S, Yesilot N, Yentur SP, Kurtuncu M (2008) Interleukin-6 in neuro-Behcet’s disease: association with disease subsets and long-term outcome. Cytokine 3:373–376

    Article  Google Scholar 

  14. Borhani Haghighi A, Ittehadi H, Nikseresht AR et al (2009) CSF levels of cytokines in neuro-Behçet’s disease. Clin Neurol Neurosurg 111:507–510

    Article  PubMed  CAS  Google Scholar 

  15. Akman–Demir G, Serdaroglu P, Tasci B, The Neuro-Behçet’s Study Group (1999) Clinical patterns of neurological involvement in Behçet’s disease: evaluation of 200 patients. Brain 122:2171–2182

    Article  PubMed  Google Scholar 

  16. Coban O, Bahar S, Akman-Demir G et al (1999) Masked assessment of MRI findings: is it possible to differentiate neuro-Behçet’s disease from other central nervous system. Neuroradiology 41:255–260

    Article  PubMed  CAS  Google Scholar 

  17. Ashjazadeh N, Borhani Haghighi A, Samangooie SH, Moosavi H (2003) Neuro-Behcet’s disease: a masquerader of multiple sclerosis. A prospective study of neurologic manifestations of Behcet’s disease in 96 Iranian patients. Exp Mol Pathol 74:17–22

    Article  PubMed  CAS  Google Scholar 

  18. Wechsler B, Dell’lsola B, Vidailhet M et al (1993) MRI in 31 patients with Behget’s disease and neurological involvement: prospective study with clinical correlation. J Neurol Neurosurg Psychiatry 56:793–798

    Article  PubMed  CAS  Google Scholar 

  19. Borhani Haghighi A (2009) Treatment of Neuro-Behçet’s disease: an update. Exp Rev Neurother 9:565–574

    Article  Google Scholar 

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Acknowledgment

The authors would like to thank the Office of Vice Chancellor for Research in Shiraz University of Medical Sciences for the financial support of this study (grant no.3867). We would also like to express our gratitude to Dr. Farrokh Habibzadeh for the editorial assistance and Dr. Mehrdad Vossoughi for the statistical analysis.

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Correspondence to Afshin Borhani Haghighi.

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Borhani Haghighi, A., Sarhadi, S. & Farahangiz, S. MRI findings of neuro-Behcet’s disease. Clin Rheumatol 30, 765–770 (2011). https://doi.org/10.1007/s10067-010-1650-9

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  • DOI: https://doi.org/10.1007/s10067-010-1650-9

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