Skip to main content

Advertisement

Log in

Impact of tight control strategy on rheumatoid arthritis in Sarawak

  • Original Article
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

The aim of our study is to describe the impact of tight control strategy on the care of RA patients in Sarawak General Hospital. We performed a prospective study of all patients with a diagnosis of RA who received treatment at the Rheumatology Clinic in Sarawak General Hospital over a 1-year period. Systematic DAS-driven treatment adjustments aimed to achieve low disease activity (DAS 28-ESR <2.6) were carried out in the clinic over the 1-year period. Disease activity and treatment regimes of all 142 patients were collected for at baseline and 1 year later for statistical analysis. Our patients have a significantly lower DAS 28 with a mean of 2.99 ± 0.95 compared with baseline of 4.31 ± 1.34 (p < 0.000). More patients were in remission 1 year later compared to baseline (36.6% vs 11.3%). Tight control strategy has a positive impact on the care of RA patients in our centre. By optimising the care of RA through tight control strategy, RA can be better controlled in our centre.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Teh CL, Wong JS (2008) The pattern and clinical manifestations of rheumatoid arthritis in Sarawak General Hospital. Clin Rheumatol 27(11):1437–1440, Epub 2008 Sep 5

    Article  PubMed  CAS  Google Scholar 

  2. Klarenbeek NB, Allaart CF, Kerstens PJ, Huizinga TW, Dijkmans BA (2009) The BeSt story: on strategy trials in rheumatoid arthritis. Curr Opin Rheumatol 21(3):291–298

    Article  PubMed  Google Scholar 

  3. Grigor C, Capell H, Stirling A et al (2004) Effect of a treatment strategy of tight control of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomized controlled trial. Lancet 364:263–269

    Article  PubMed  Google Scholar 

  4. Goekoop-Ruiterman YP, de Vries-Bouwstra JK, Kerstens PJ, Nielen MM, Vos K, van Schaardenburg D, Speyer I, Seys PE, Breedveld FC, Allaart CF, Dijkmans BA (2009) (2009) DAS-driven therapy versus routine care in patients with recent-onset active Rheumatoid Arthritis. Ann Rheum Dis 69(1):65–69

    Article  Google Scholar 

  5. Bakker MF, Jacobs JW, Verstappen SM, Bijlsma JW (2007) Tight control in the treatment of rheumatoid arthritis: efficacy and feasibility. Ann Rheum Dis 66(Suppl 3):iii56–iii60

    Article  PubMed  Google Scholar 

  6. Allaart CF, Goekoop-Ruiterman YP, de Vries-Bouwstra JK, Breedveld FC, Dijkmans BA, FARR study group (2006) Aiming at low disease activity in rheumatoid arthritis with initial combination therapy or initial monotherapy strategies: the BeSt study. Clin Exp Rheumatol 24(6 Suppl 43):S-77–S-82

    Google Scholar 

  7. Verstappen SM, Jacobs JW, van der Veen MJ, Heurkens AH, Schenk Y, ter Borg EJ, Blaauw AA, Bijlsma JW, Utrecht Rheumatoid Arthritis Cohort study group (2007) Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial). Ann Rheum Dis 66:1443–1449

    Article  PubMed  CAS  Google Scholar 

  8. Fransen J, Moens HB, Speyer I, van Riel PL (2005) Effectiveness of systematic monitoring of rheumatoid arthritis disease activity in daily practice: a multicentre, cluster randomised controlled trial. Ann Rheum Dis 64:1294–1298

    Article  PubMed  CAS  Google Scholar 

  9. Katchamart W, Bombardier C (2010) Systematic monitoring of disease activity using an outcome measure improves outcomes in rheumatoid arthritis. J Rheumatol 37(7):1411–1415, Epub 2010 May 1

    Article  PubMed  Google Scholar 

  10. Arnett FC, Edworthy SM, Bloch DA et al (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324

    Article  PubMed  CAS  Google Scholar 

  11. Prevoo ML, van’t Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL (1995) Modified disease activity scores that include twenty-eight-joint counts: Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 38:44–48

    Article  PubMed  CAS  Google Scholar 

  12. van Riel PL, van Restel AM (2000) Clinical outcome measures in rheumatoid arthritis. Ann Rheum Dis 59(Suppl 1):i28–i31

    Article  PubMed  Google Scholar 

  13. Hochberg MC, Chang RW, Dwosh I, Lindsey S, Pincus T, Wolfe F (1992) The American College of Rheumatology 1991 revised criteria for the classification of global functional status in rheumatoid arthritis. Arthritis Rheum 35(5):498–502

    Article  PubMed  CAS  Google Scholar 

  14. Health Facts Sarawak 2006. Sarawak State Health Department (Information and Documentation Unit)

  15. Combe B, Landewe R, Lukas C, Bolosiu HD, Breedveld F, Dougados M, Emery P, Ferraccioli G, Hazes JM, Klareskog L, Machold K, Martin-Mola E, Nielsen H, Silman A, Smolen J, Yazici H (2007) EULAR recommendations for the management of early arthritis: report of a task force of the European Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 66(1):34–45, Epub 2006 Jan 5

    Article  PubMed  CAS  Google Scholar 

  16. Sokka T, Kautiainen H, Toloza S et al (2007) QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries. Ann Rheum Dis 66:1491–1496, Epub 2007 Apr 5

    Article  PubMed  Google Scholar 

  17. Möttönen T, Hannonen P, Korpela M, FIN-RACo Trial Group. FINnish Rheumatoid Arthritis Combination therapy et al (2002) Delay to institution of therapy and induction of remission using single-drug or combination-disease-modifying antirheumatic drug therapy in early rheumatoid arthritis. Arthritis Rheum 46(4):894–898

    Article  PubMed  Google Scholar 

  18. Drossaers-Bakker KW, Zwinderman AH, Vliet Vlieland TP, Van Zeben D, Vos K, Breedveld FC, Hazes JM (2002) Long-term outcome in rheumatoid arthritis: a simple algorithm of baseline parameters can predict radiographic damage, disability, and disease course at 12-year follow up. Arthritis Rheum 47(4):383–390

    Article  PubMed  CAS  Google Scholar 

  19. van Zeben D, Breedveld FC (1996) Prognostic factors in rheumatoid arthritis. J Rheumatol 44:31–33

    Google Scholar 

  20. Sokka T, Pincus T (2008) Ascendancy of weekly low-dose methotrexate in usual care of rheumatoid arthritis from 1980 to 2004 at two sites in Finland and the United States. Rheumatology (Oxford) 47(10):1543–1547, Epub 2008 Aug 7

    Article  CAS  Google Scholar 

  21. Sokka T, Pincus T (2002) Contemporary disease modifying antirheumatic drugs (DMARD) in patients with recent onset rheumatoid arthritis in a US private practice: methotrexate as the anchor drug in 90% and new DMARD in 30% of patients. J Rheumatol 29:2521–2524

    PubMed  CAS  Google Scholar 

  22. Ward MM, Fries JF (1998) Trends in antirheumatic medication use among patients with rheumatoid arthritis, 1981–1996. J Rheumatol 25:408–416

    PubMed  CAS  Google Scholar 

  23. Mikuls TR (2000) Trends in antirheumatic medication use among patients with rheumatoid arthritis, 1981–1996. Arthritis Rheum 43:464–467

    Article  PubMed  CAS  Google Scholar 

  24. Klaukka T, Kaarela K (2003) Methotrexate is the leading DMARD in Finland. Ann Rheum Dis 62:494–496

    Article  PubMed  CAS  Google Scholar 

  25. Saunders SA, Capell HA, Stirling A, Vallance R, Kincaid W, McMahon AD, Porter DR (2008) Triple therapy in early active rheumatoid arthritis: a randomized, single-blind, controlled trial comparing step-up and parallel treatment strategies. Arthritis Rheum 58(5):1310–1317

    Article  PubMed  CAS  Google Scholar 

  26. O'Dell JR, Leff R, Paulsen G et al (2002) Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications: results of a two-year, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 46(5):1164–1170

    Article  PubMed  Google Scholar 

  27. Möttönen T, Hannonen P, Leirisalo-Repo M et al (1999) Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: a randomised trial FIN-RACo trial group. Lancet 353(9164):1568–1573

    Article  PubMed  Google Scholar 

  28. Schipper LG, van Hulst LT, Grol R, van Riel PL, Hulscher ME, Fransen J (2010) Meta-analysis of tight control strategies in rheumatoid arthritis: protocolized treatment has additional value with respect to the clinical outcome. Rheumatology (Oxford). doi:10.1093/rheumatology/keq195

Download references

Acknowledgements

We would like to acknowledge the support of the Ministry of Health, Malaysia for technical support of the study.

Disclosures

None

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Cheng Lay Teh.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Teh, C.L., Wong, J.S. Impact of tight control strategy on rheumatoid arthritis in Sarawak. Clin Rheumatol 30, 615–621 (2011). https://doi.org/10.1007/s10067-010-1583-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-010-1583-3

Keywords

Navigation