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Autoantibodies for gastrointestinal organ-specific autoimmune diseases in rheumatoid arthritis patients and their relatives

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Abstract

Background

Clustering of autoimmune diseases is common and may be due to genetic background and exposition to environmental triggers.

Objective

The aim is to carry out a laboratory and clinical study of the prevalence of gastrointestinal organ-specific autoantibodies in rheumatoid arthritis (RA) patients and their relatives.

Methods

Serum samples of 156 RA patients, 200 relatives, and 100 healthy controls were studied for anti-smooth muscle antibody (ASMA), anti-mitochondrial (AMA), anti-parietal cell (APCA), anti-liver–kidney microsome (LKM), and anti-endomysium antibodies (IgA-EmA) by indirect immunofluorescence.

Results

A total of eight out of the 156 (5.1%) RA patients were positive for the autoantibodies (ASMA = 1; AMA = 2, APCA = 5). In the relative group, 12/200 (6%) had at least one positive autoantibody (ASMA = 1; AMA = 2, APCA = 7, IgA-EmA = 2). In the control group, two out of the100 (2%) healthy controls were positive (ASMA = 1, APCA = 1). No statistical difference was found between RA patients, their relatives, and controls in relation to the frequency of autoantibodies evaluated.

Conclusion

Although RA patients and their relatives have positivity of AMA, ASMA, and APCA without statistical difference in relation to healthy individuals, the findings may be of value for adequate clinical approach of these subjects.

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References

  1. Nancy AL, Yehuda S (2009) Prediction and prevention of autoimmune disorders. Arch Dermatol Res 301:57–64

    Article  PubMed  Google Scholar 

  2. Michou L, Rat AC, Lasbleiz S, Bardin T, Cornélis F (2008) Prevalence and distribution of autoimmune diseases in 368 rheumatoid arthritis families. J Rheumatol 35:790–796

    PubMed  Google Scholar 

  3. Anderson JR (2001) Rheumatoid Arthritis. Clinical and laboratory features. In: Klippel JH, Crofford LJ, Stone JH, Weyand CM (eds) Primer on Rheumatic Diseases, 12th edn. Arthritis Foundation, Atlanta

    Google Scholar 

  4. Hemminki K, Li X, Sundqvist J, Sundquist K (2009) Familial associations of rheumatoid arthritis with autoimmune diseases and related conditions. Arthritis Rheum 60:661–668

    Article  PubMed  Google Scholar 

  5. Mosca M, Carli L, d’Ascanio A, Tani C, Talarico R, Baldini C et al (2008) Occurrence of organ specific and systemic autoimmune diseases among the first and second relatives of Caucasian patients with connective tissue diseases: report of data obtained through direct patient interview. Clin Rheumatol 27:1045–1048

    Article  PubMed  Google Scholar 

  6. Volta U, Molinaro N, de Franceschi L, Fratangelo D, Bianchi FB (1995) IgA anti-endomysial antibodies on human umbilical cord tissue for celiac disease screening. Dig Dis Sci 9:1902–1905

    Article  Google Scholar 

  7. Marie I, Levesque H, Transvouez JL, Riachi G, Cailleux N, Courtois H (2001) Autoimmune hepatitis and systemic sclerosis: a new overlap syndrome? Rheumatology 40:102–106

    Article  CAS  PubMed  Google Scholar 

  8. Irving KS, Sen D, Tahir H, Pilkington C, Isenberg DA (2007) A comparison of autoimmune liver disease in juvenile and adult populations with systemic lupus erythematosus—a retrospective review of cases. Rheumatology 46:1171–1173

    Article  CAS  PubMed  Google Scholar 

  9. Muratori L, Granito A, Muratori P, Pappas G, Bianchi FB (2008) Antimitochondrial antibodies and other antibodies in primary biliary cirrhosis: diagnostic and prognostic value. Clin Liver Dis 12:261–276

    Article  PubMed  Google Scholar 

  10. Metcalf JV, Mitchison HC, Palmer JM, Jones DE, Bassendine MF, James OF (1996) Natural history of early primary biliary cirrhosis. Lancet 348:1399–1402

    Article  CAS  PubMed  Google Scholar 

  11. Gregorio GV, Portmann B, Reid F, Donaldson PT, Doherty DG, McCartney M (1997) Autoimmune hepatitis in childhood: a 20 year experience. Hepatology 25:541–547

    Article  CAS  PubMed  Google Scholar 

  12. Kotze LMS, Utiyama SRR, Nisihara RM, Camargo VF, Ioshii SO (2003) IgA class antiendomysial and anti-tissue transglutaminase antibodies in relation to duodenal mucosa changes in celiac disease. Pathology 35:56–60

    Article  PubMed  Google Scholar 

  13. Utiyama SR, Nass FR, Kotze LM, Nisihara RM, Ambrosio AR, Messias-Reason IT (2007) Serological screening in celiac disease patients: antiendomysium antibodies, anti tissue transglutaminase or both? Arq Gastroenterol 44:156–161

    Article  PubMed  Google Scholar 

  14. Tursi A, Brandimarte G, Giorgetti G, Gigliobianco A, Lombardi D, Gasbarrini G (2001) Low prevalence of antigliadin and antiendomysium antibodies in subclinical/silent celiac disease. Am J Gastroenterol 96:1507–1510

    Article  CAS  PubMed  Google Scholar 

  15. Sugiu K, Kamada T, Ito M, Kaya S, Tanaka A, Kusunoki H, Hata J, Haruma K (2006) Evaluation of an Elisa for detection of anti parietal cell antibody. Hepato-Gastroenterol 53:11–14

    CAS  Google Scholar 

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Acknowledgments

This work was partially supported by a grant from the Araucária Foundation-Paraná.

Disclosures

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Authors and Affiliations

  1. Laboratory of Immunopathology, Clinical Hospital, Federal University of Paraná, Curitiba, Paraná, Brazil

    Isabela Goeldner, Iara T. de Messias Reason, Renato M. Nisihara & Shirley R. da Rosa Utiyama

  2. Rheumatology Unit, Evangelical University Hospital of Curitiba, Curitiba, Paraná, Brazil

    Thelma L. Skare & Marília B. Silva

  3. Departamento de Patologia Médica, Setor de Ciências da Saúde, Laboratório de Imunopatologia, Rua Padre Camargo, 280, CEP 80060-240, Curitiba, Paraná, Brazil

    Shirley R. da Rosa Utiyama

Authors
  1. Isabela Goeldner
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  2. Thelma L. Skare
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  3. Iara T. de Messias Reason
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  4. Renato M. Nisihara
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  5. Marília B. Silva
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  6. Shirley R. da Rosa Utiyama
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Corresponding author

Correspondence to Shirley R. da Rosa Utiyama.

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Goeldner, I., Skare, T.L., de Messias Reason, I.T. et al. Autoantibodies for gastrointestinal organ-specific autoimmune diseases in rheumatoid arthritis patients and their relatives. Clin Rheumatol 30, 99–102 (2011). https://doi.org/10.1007/s10067-010-1540-1

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  • DOI: https://doi.org/10.1007/s10067-010-1540-1

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