Clinical Rheumatology

, Volume 29, Issue 12, pp 1353–1356 | Cite as

QT dispersion in uncomplicated familial Mediterranean fever

  • Naomi Nussinovitch
  • Avi Livneh
  • Keren Katz
  • Pnina Langevitz
  • Olga Feld
  • Moshe Nussinovitch
  • Benjamin Volovitz
  • Merav Lidar
  • Udi Nussinovitch
Original Article


The aim of the study was to further evaluate repolarization dispersion in familial Mediterranean fever (FMF). Findings on 12-lead electrocardiography were compared with 32 patients with uncomplicated FMF and age- and sex-matched control subjects. All procedures followed stringent standards. Repolarization and dispersion parameters were computed with designated computer software, and results of the five beats were subsequently averaged. There were no statistically significant differences between the groups in average QT and average corrected QT interval length, average QT interval dispersion, average QT corrected dispersion, or QT dispersion ratio. During 6 months of follow-up, no cases of sudden death or arrhythmia were documented in either group. Patients with FMF who are continuously treated with low-dose colchicine and have not developed amyloidosis seem to have QT dispersion parameters similar to those of healthy subjects and therefore apparently have no increased risk of adverse cardiac events associated with abnormal repolarization.


Arrhythmia Atherosclerosis Familial Mediterranean fever QT dispersion (QTd) 



familial Mediterranean fever


QT interval dispersion


corrected QT


QT corrected dispersion


QT dispersion ratio


  1. 1.
    Simon A, van der Meer JW, Drenth JP (2005) Familial Mediterranean fever—a not so unusual cause of abdominal pain. Best Pract Res Clin Gastroenterol 19:199–213CrossRefPubMedGoogle Scholar
  2. 2.
    Onen F (2006) Familial Mediterranean fever. Rheumatol Int 26:489–496CrossRefPubMedGoogle Scholar
  3. 3.
    Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T, Migdal A, Padeh S, Pras M (1997) Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 40:1879–1885CrossRefPubMedGoogle Scholar
  4. 4.
    Lidar M, Zandman-Goddard G, Shinar Y, Zaks N, Livneh A, Langevitz P (2008) Systemic lupus erythematosus and familial Mediterranean fever: a possible negative association between the two disease entities—report of four cases and review of the literature. Lupus 17:663–669CrossRefPubMedGoogle Scholar
  5. 5.
    Bakkaloglu A (2003) Familial Mediterranean fever. Pediatr Nephrol 18:853–859CrossRefPubMedGoogle Scholar
  6. 6.
    Rabinovitch E, Harats D, Yaron P, Luvish T, Lidar M, Kedem R, Shaish A, Ben-Dov I, Livneh A (2007) Familial Mediterranean fever gene and protection against asthma. Ann Allergy Asthma Immunol 99:517–521CrossRefPubMedGoogle Scholar
  7. 7.
    Berkun Y, Padeh S, Reichman B, Zaks N, Rabinovich E, Lidar M, Shainberg B, Livneh A (2007) A single testing of serum amyloid a levels as a tool for diagnosis and treatment dilemmas in familial Mediterranean fever. Semin Arthritis Rheum 37:182–188CrossRefPubMedGoogle Scholar
  8. 8.
    Langevitz P, Livneh A, Neumann L, Buskila D, Shemer J, Amolsky D, Pras M (2001) Prevalence of ischemic heart disease in patients with familial Mediterranean fever. Isr Med Assoc J 3:9–12PubMedGoogle Scholar
  9. 9.
    Akcay A, Acar G, Sayarlioglu M, Sokmen A, Kaya H, Ispiroglu M, Koroglu S (2009) QT dispersion and transmural dispersion of repolarization in patients with familial Mediterranean fever. Mod Rheumatol 19:550–555CrossRefPubMedGoogle Scholar
  10. 10.
    Zabel M, Klingenheben T, Franz MR, Hohnloser SH (1998) Assessment of QT dispersion for prediction of mortality or arrhythmic events after myocardial infarction: results of a prospective, long-term follow-up study. Circulation 97:2543–2550PubMedGoogle Scholar
  11. 11.
    Goldenberg I, Moss AJ, Zareba W (2006) QT interval: how to measure it and what is “normal”. J Cardiovasc Electrophysiol 17:333–336CrossRefPubMedGoogle Scholar
  12. 12.
    Wislowska M, Jaszczyk B, Kochmański M, Sypuła S, Sztechman M (2008) Diastolic heart function in RA patients. Rheumatol Int 28:513–9CrossRefPubMedGoogle Scholar
  13. 13.
    Achong N, Wahi S, Marwick TH (2009) Evolution and outcome of diastolic dysfunction. Heart 95:813–818CrossRefPubMedGoogle Scholar
  14. 14.
    Tavil Y, Ureten K, Ozturk MA, Sen N, Kaya MG, Cemri M, Cengel A (2008) The detailed assessment of left and right ventricular functions by tissue Doppler imaging in patients with familial Mediterranean fever. Clin Rheumatol 27:189–194CrossRefPubMedGoogle Scholar
  15. 15.
    Baysal T, Peru H, Oran B, Sahin TK, Koksal Y, Karaaslan S (2009) Left ventricular diastolic function evaluated with tissue Doppler imaging in children with familial Mediterranean fever. Clin Rheumatol 28:23–28CrossRefPubMedGoogle Scholar
  16. 16.
    Nussinovitch U, Shoenfeld Y (2009) Autoimmunity and heart diseases: pathogenesis and diagnostic criteria. Arch Immunol Ther Exp 57:95–104CrossRefGoogle Scholar
  17. 17.
    Sari I, Karaoglu O, Can G, Akar S, Gulcu A, Birlik M, Akkoc N, Tunca M, Goktay Y, Onen F (2007) Early ultrasonographic markers of atherosclerosis in patients with familial Mediterranean fever. Clin Rheumatol 26:1467–1473CrossRefPubMedGoogle Scholar
  18. 18.
    Akdogan A, Calguneri M, Yavuz B, Arslan EB, Kalyoncu U, Sahiner L, Karadag O, Ertenli I, Kiraz S, Aytemir K, Akata D, Tokgozoglu L, Oto A (2006) Are familial Mediterranean fever (FMF) patients at increased risk for atherosclerosis? Impaired endothelial function and increased intima media thickness are found in FMF. J Am Coll Cardiol 48:2351–2353CrossRefPubMedGoogle Scholar
  19. 19.
    Yilmaz R, Demirbag R, Gur M (2006) The association of QT dispersion and QT dispersion ratio with extent and severity of coronary artery disease. Ann Noninvasive Electrocardiol 11:43–51CrossRefPubMedGoogle Scholar
  20. 20.
    Nussinovitch U, Katz U, Nussinovitch M, Nussinovitch N (2009) Late ventricular potentials and QT dispersion in familial dysautonomia. Pediatr Cardiol 30:747–751CrossRefPubMedGoogle Scholar
  21. 21.
    Malik M, Batchvarov VN (2000) Measurement, interpretation and clinical potential of QT dispersion. J Am Coll Cardiol 36:1749–1766CrossRefPubMedGoogle Scholar
  22. 22.
    Rautaharju PM (2002) Why did QT dispersion die? Card Electrophysiol Rev 6:295–301CrossRefPubMedGoogle Scholar
  23. 23.
    Savelieva I, Yi G, Guo X, Hnatkova K, Malik M (1998) Agreement and reproducibility of automatic versus manual measurement of QT interval and QT dispersion. Am J Cardiol 81:471–477CrossRefPubMedGoogle Scholar

Copyright information

© Clinical Rheumatology 2010

Authors and Affiliations

  • Naomi Nussinovitch
    • 1
    • 2
  • Avi Livneh
    • 2
    • 3
  • Keren Katz
    • 2
  • Pnina Langevitz
    • 2
    • 3
  • Olga Feld
    • 2
    • 3
  • Moshe Nussinovitch
    • 2
    • 4
  • Benjamin Volovitz
    • 2
    • 4
  • Merav Lidar
    • 2
    • 3
  • Udi Nussinovitch
    • 2
    • 5
  1. 1.Hypertension Unit and Department of Internal Medicine DSheba Medical CenterTel HashomerIsrael
  2. 2.Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  3. 3.The Heller Institute of Medical Research, and Department of Medicine FSheba Medical CenterTel HashomerIsrael
  4. 4.Department of Pediatrics CSchneider Children’s Medical Center of IsraelPetach TikvaIsrael
  5. 5.Department of Internal Medicine BSheba Medical CenterTel HashomerIsrael

Personalised recommendations