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Quantitative alterations of CD8+ T cells in juvenile idiopathic arthritis patients in remission

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Abstract

The study was aimed to investigate whether quantities of CD8+ T cell subsets are normal in juvenile idiopathic arthritis (JIA) patients with disease remission compared to age-matched healthy donors (HD) and whether chronological age may have an impact on proportions of naive CD8+ T cells. CD8+ T cell subsets were analyzed in 17 JIA patients and 32 age-matched HD by flow cytometry. JIA patients showed lower CD3+CD8+ T cells compared to HD. Total counts of CD8+CD28+ and CD8+CD28+CD45RA+ T cells were inversely correlated to chronological age in JIA patients and HD. In JIA patients, percentages of CD8+CD28+CD45RA+ T cells and of CD62L-expressing CD8+CD28+CD45RA+ T cells showed a negative correlation with age. The trend to lower CD28+CD45RA+ T cell proportions in aged JIA patients in remission may reflect a disturbed T cell homeostasis independently of disease activity and may be due to an intrinsic effect in reconstitution of the peripheral T cells.

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Acknowledgment

The study was supported by the Medical Research Fund Tyrol (MFF Tirol, granted to Martina Prelog, project number 105), the Tyrolean Science Fund (TWF, granted to Martina Prelog, project number 2006-2-425), and the Dr. Kolassa Rheumatology Award (granted to Martina Prelog).

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Authors and Affiliations

  1. Department of Pediatrics, Pediatrics I, Medical University Innsbruck, Anichstr. 35, 6020, Innsbruck, Austria

    Martina Prelog, Nora Schwarzenbrunner, Elisabeth Tengg, Michaela Sailer-Höck, Lothar Bernd Zimmerhackl & Juergen Brunner

  2. Department of Pediatrics, Pediatrics II, Medical University Innsbruck, Innsbruck, Austria

    Hannelore Kern

Authors
  1. Martina Prelog
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  2. Nora Schwarzenbrunner
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  3. Elisabeth Tengg
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  4. Michaela Sailer-Höck
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  5. Hannelore Kern
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  6. Lothar Bernd Zimmerhackl
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  7. Juergen Brunner
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Correspondence to Martina Prelog.

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Prelog, M., Schwarzenbrunner, N., Tengg, E. et al. Quantitative alterations of CD8+ T cells in juvenile idiopathic arthritis patients in remission. Clin Rheumatol 28, 385–389 (2009). https://doi.org/10.1007/s10067-008-1057-z

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  • DOI: https://doi.org/10.1007/s10067-008-1057-z

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