Skip to main content

Advertisement

Log in

Proliferative lupus nephritis in a patient with systemic lupus erythematosus and longstanding secondary amyloid nephropathy

  • Case Report
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

Secondary amyloidosis is an unusual complication of systemic lupus erythematosus (SLE). We report the case of a 60-year-old woman with SLE and secondary amyloidosis who developed class III proliferative lupus nephritis 13 years after the onset of amyloid nephropathy. The patient was treated with mycophenolate mofetil (1.5 g/day) with a significant improvement in proteinuria.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Ellington KT, Truong L, Olivero JJ (1993) Renal amyloidosis in systemic lupus erythematosus. Am J Kidney Dis 21:676–678

    PubMed  CAS  Google Scholar 

  2. Queffeulou G, Berenbaum F, Michel C, Mougenot B, Mignon F (1998) AA amyloidosis in systemic lupus erythematosus: an unusual complication. Nephrol Dial Transplant 13:1846–1848

    Article  PubMed  CAS  Google Scholar 

  3. Duzgun N, Tokgoz G, Olmez U, Aydintug O (1999) Systemic amyloidosis and sacroiliitis in a patient with systemic lupus erythematosus. Rheumatol Int 18:153–155

    Article  PubMed  CAS  Google Scholar 

  4. Singh NP, Prakash A, G S, Dinda AK, Agarwal SK (2003) Renal and systemic amyloidosis in systemic lupus erythematosus. Ren Fail 25:671–675

    Article  PubMed  Google Scholar 

  5. Aktas Yilmaz B, Duzgun N, Mete T et al (2008) AA amyloidosis associated with systemic lupus erythematosus: impact on clinical course and outcome. Rheumatol Int 28:367–370

    Article  PubMed  Google Scholar 

  6. Orellana C, Collado A, Hernandez MV, Font J, Del Olmo JA, Muñoz-Gómez J (1995) When does amyloidosis complicate systemic lupus erithematosus? Lupus 4:415–417

    Article  PubMed  CAS  Google Scholar 

  7. Baranowska-Daca E, Choi YJ, Barrios R, Nassar G, Suki WN, Troung LD (2001) Nonlupus nephritides in patients with systemic lupus erythematosus: a comprehensive clinicopathologic study and review of the literature. Hum Pathol 32:1125–1135

    Article  PubMed  CAS  Google Scholar 

  8. Appel GB, Pirani CL, D’Agati V (1994) Renal vascular complications of systemic lupus erythematosus. J Am Soc Nephrol 4:1499–1515

    PubMed  CAS  Google Scholar 

  9. Bogov B, Kiperova B, Dzherasi R, Andreev E, Minkova V (1999) Secondary systemic amyloidosis A combined with primary glomerulonephritis and systemic diseases. Vutr Boles 31:19–22

    PubMed  CAS  Google Scholar 

  10. Maury CP, Teppo AM, Wegelius O (1982) Relationship between urinary sialylated saccharides, serum amyloid A protein, and C-reactive protein in rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis 41:268–271

    Article  PubMed  CAS  Google Scholar 

  11. Ho CT, Mok CC, Lau CS, Wong RW (1998) Late onset systemic lupus erythematosus in southern Chinese. Ann Rheum Dis 57:437–440

    Article  PubMed  CAS  Google Scholar 

  12. Boddaert J, Huong DL, Amoura Z, Wechsler B, Godeau P, Piette JC (2004) Late-onset systemic lupus erythematosus: a personal series of 47 patients and pooled analysis of 714 cases in the literature. Medicine (Baltimore) 83:348–359

    Article  Google Scholar 

  13. Mak A, Mok CC, Chu WP, To CH, Wong SN, Au TC (2007) Renal damage in systemic lupus erythematosus: a comparative analysis of different age groups. Lupus 16:28–34

    Article  PubMed  CAS  Google Scholar 

  14. Moore RA, Derry S (2006) Systematic review and meta-analysis of randomised trials and cohort studies of mycophenolate mofetil in lupus nephritis. Arthritis Res Ther 8:R182

    Article  PubMed  CAS  Google Scholar 

  15. Najafi CC, Korbet SM, Lewis EJ, Schwartz MM, Reichlin M, Evans J (2001) Lupus Nephritis Collaborative Study Group. Significance of histologic patterns of glomerular injury upon long-term prognosis in severe lupus glomerulonephritis. Kidney Int 59:2156–2163

    PubMed  CAS  Google Scholar 

Download references

Acknowledgements

We thank David Buss for his editorial assistance.

Conflict of interest

Disclosures: none

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jose A. Gómez-Puerta.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gómez-Puerta, J.A., Cervera, R., Moll, C. et al. Proliferative lupus nephritis in a patient with systemic lupus erythematosus and longstanding secondary amyloid nephropathy. Clin Rheumatol 28, 95–97 (2009). https://doi.org/10.1007/s10067-008-1025-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-008-1025-7

Keywords

Navigation