Abstract
Secondary amyloidosis is an unusual complication of systemic lupus erythematosus (SLE). We report the case of a 60-year-old woman with SLE and secondary amyloidosis who developed class III proliferative lupus nephritis 13 years after the onset of amyloid nephropathy. The patient was treated with mycophenolate mofetil (1.5 g/day) with a significant improvement in proteinuria.
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Ellington KT, Truong L, Olivero JJ (1993) Renal amyloidosis in systemic lupus erythematosus. Am J Kidney Dis 21:676–678
Queffeulou G, Berenbaum F, Michel C, Mougenot B, Mignon F (1998) AA amyloidosis in systemic lupus erythematosus: an unusual complication. Nephrol Dial Transplant 13:1846–1848
Duzgun N, Tokgoz G, Olmez U, Aydintug O (1999) Systemic amyloidosis and sacroiliitis in a patient with systemic lupus erythematosus. Rheumatol Int 18:153–155
Singh NP, Prakash A, G S, Dinda AK, Agarwal SK (2003) Renal and systemic amyloidosis in systemic lupus erythematosus. Ren Fail 25:671–675
Aktas Yilmaz B, Duzgun N, Mete T et al (2008) AA amyloidosis associated with systemic lupus erythematosus: impact on clinical course and outcome. Rheumatol Int 28:367–370
Orellana C, Collado A, Hernandez MV, Font J, Del Olmo JA, Muñoz-Gómez J (1995) When does amyloidosis complicate systemic lupus erithematosus? Lupus 4:415–417
Baranowska-Daca E, Choi YJ, Barrios R, Nassar G, Suki WN, Troung LD (2001) Nonlupus nephritides in patients with systemic lupus erythematosus: a comprehensive clinicopathologic study and review of the literature. Hum Pathol 32:1125–1135
Appel GB, Pirani CL, D’Agati V (1994) Renal vascular complications of systemic lupus erythematosus. J Am Soc Nephrol 4:1499–1515
Bogov B, Kiperova B, Dzherasi R, Andreev E, Minkova V (1999) Secondary systemic amyloidosis A combined with primary glomerulonephritis and systemic diseases. Vutr Boles 31:19–22
Maury CP, Teppo AM, Wegelius O (1982) Relationship between urinary sialylated saccharides, serum amyloid A protein, and C-reactive protein in rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis 41:268–271
Ho CT, Mok CC, Lau CS, Wong RW (1998) Late onset systemic lupus erythematosus in southern Chinese. Ann Rheum Dis 57:437–440
Boddaert J, Huong DL, Amoura Z, Wechsler B, Godeau P, Piette JC (2004) Late-onset systemic lupus erythematosus: a personal series of 47 patients and pooled analysis of 714 cases in the literature. Medicine (Baltimore) 83:348–359
Mak A, Mok CC, Chu WP, To CH, Wong SN, Au TC (2007) Renal damage in systemic lupus erythematosus: a comparative analysis of different age groups. Lupus 16:28–34
Moore RA, Derry S (2006) Systematic review and meta-analysis of randomised trials and cohort studies of mycophenolate mofetil in lupus nephritis. Arthritis Res Ther 8:R182
Najafi CC, Korbet SM, Lewis EJ, Schwartz MM, Reichlin M, Evans J (2001) Lupus Nephritis Collaborative Study Group. Significance of histologic patterns of glomerular injury upon long-term prognosis in severe lupus glomerulonephritis. Kidney Int 59:2156–2163
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We thank David Buss for his editorial assistance.
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Gómez-Puerta, J.A., Cervera, R., Moll, C. et al. Proliferative lupus nephritis in a patient with systemic lupus erythematosus and longstanding secondary amyloid nephropathy. Clin Rheumatol 28, 95–97 (2009). https://doi.org/10.1007/s10067-008-1025-7
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DOI: https://doi.org/10.1007/s10067-008-1025-7