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Non-episodic angioedema associated with eosinophilia following Mycoplasma pneumoniae infection

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Abstract

Episodic angioedema with eosinophilia is characterized by recurrent angioedema, peripheral eosinophilia, fever, weight gain, elevated serum immunoglobulin M (IgM), and a benign course lacking any internal organ involvement. A non-episodic variant has also been reported which is limited to a single attack and normally is less severe than the episodic type. We report a case of Mycoplasma pneumoniae infection with dermatological manifestation that was followed by non-episodic angioedema with eosinophilia including fever, weight gain, and elevated serum IgM. Even though the patient’s clinical characteristics resemble episodic angioedema with eosinophilia as reported by Gleich, angioedema was non-episodic. This may be due to systemic corticosteroid treatment which was prescribed because of persistent skin manifestation following M. pneumoniae infection. The current report is the first observation suggesting that angioedema associated with eosinophilia may be triggered by atypical bacterial infection.

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Acknowledgments

The authors wish to thank Rajam Csordas for critical reading.

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Authors and Affiliations

  1. Department of Internal Medicine, Central Hospital of Bolzano, Lorenz Böhler Street 5, 39100, Bolzano (BZ), Italy

    Ingrid Stockner & Christian J. Wiedermann

  2. Division of Dermatology, Central Hospital of Bolzano, Bolzano, Italy

    Josef Thaler & Werner Wallnöfer

  3. Division of Pathological Anatomy and Histology, Central Hospital of Bolzano, Bolzano, Italy

    Gertrud Fichtel & Eduard Egarter-Vigl

Authors
  1. Ingrid Stockner
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  2. Josef Thaler
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  3. Gertrud Fichtel
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  4. Eduard Egarter-Vigl
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  5. Werner Wallnöfer
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  6. Christian J. Wiedermann
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Correspondence to Christian J. Wiedermann.

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Stockner, I., Thaler, J., Fichtel, G. et al. Non-episodic angioedema associated with eosinophilia following Mycoplasma pneumoniae infection. Clin Rheumatol 27, 1573–1576 (2008). https://doi.org/10.1007/s10067-008-0990-1

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  • DOI: https://doi.org/10.1007/s10067-008-0990-1

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