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Evaluation of nitric oxide synthase activity, nitric oxide, and homocysteine levels in patients with active Behcet’s disease

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Abstract

Behcet’s disease (BD) is a chronic, progressive disorder that affects many systems of the body including the eye. The aim of this study was to examine the effects of nitric oxide synthase activity (NOS), nitric oxide \(\left( {{\text{NO}}^ \bullet } \right)\), and homocysteine (Hcy) levels in patients with active BD. Included in this study were 18 male BD patients and 16 male healthy volunteers as controls. Erythrocyte NOS activity, \(\left( {{\text{NO}}^ \bullet } \right)\), erythrocyte sedimentation rate, serum C-reactive protein, and plasma Hcy values in the patients with BD were significantly higher than those of the control group. Our results show that these parameters play a major role in the inflammatory reactions observed in BD.

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Disclosures

The authors certify that they have no financial interests such as employment, stock ownership, honoraria, paid expert testimony, as well as any personal relationships, academic competition, and intellectual passion which may inappropriately influence their actions. We have had full access to all the data in the study (if applicable) and thereby accept full responsibility for the integrity of the data and the accuracy of the data analysis. We ensure that there are no conflicts of interest (both personal and institutional) regarding specific financial interests that are relevant to the work conducted or reported in this manuscript.

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Authors and Affiliations

  1. Department of Biochemistry and Clinical Biochemistry, School of Medicine, Gaziantep University, Gaziantep, Turkey

    Seyithan Taysi

  2. Department of Internal Medicine and Immunology, School of Medicine, Ataturk University, Erzurum, Turkey

    Refik Ali Sari

  3. Department of Gastroenterology, School of Medicine, Ataturk University, Erzurum, Turkey

    Hakan Dursun

  4. Department of Biochemistry, Nenehatun Obstetric and Gynecology Hospital, Erzurum, Turkey

    Adnan Yilmaz

  5. Department of Internal Medicine, School of Medicine, Ataturk University, Erzurum, Turkey

    Mustafa Keles, Kerim Cayir & Abdullah Uyanik

  6. Department of Biochemistry, School of Medicine, Ataturk University, Erzurum, Turkey

    Mehmet Akyuz & Adem Guvenc

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  1. Seyithan Taysi
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Correspondence to Seyithan Taysi.

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Taysi, S., Sari, R.A., Dursun, H. et al. Evaluation of nitric oxide synthase activity, nitric oxide, and homocysteine levels in patients with active Behcet’s disease. Clin Rheumatol 27, 1529–1534 (2008). https://doi.org/10.1007/s10067-008-0963-4

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  • DOI: https://doi.org/10.1007/s10067-008-0963-4

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