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The significance of platelet activation in ankylosing spondylitis

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Abstract

The objective of this study was to explore the significance of platelet activation in patients with ankylosing spondylitis (AS). Thirty-five AS patients and 15 normal controls were selected from November 2005 to October 2006. The number of CD62P- and CD63-positive cells were detected by flow cytometry. At the same time, the erythrocyte sedimentation rate (ESR), platelet count (PLT) and C-reactive protein (CRP) were determined in both groups. The percentage of CD62P-positive cell in AS patients (13.60 ± 7.64%) was significantly higher than that in control group (2.78 ± 1.04%; P < 0.01). The percentage of CD63-positive cell in AS patients (6.92 ± 4.16%) was significantly higher than that in control group (4.13 ± 1.85%; P < 0.05). The levels of CRP (20.18 ± 23.17 mg/l), PLT (259.54 ± 102.59 × 109/l) and ESR (36.86 ± 31.23 mm/h) in AS patients were higher than those in normal controls, respectively (3.21 ± 2.18 mg/l, P < 0.01; 197.00 ± 55.70 × 109/l, P < 0.01; 12.25 ± 5.05 mm/h, P < 0.05). Platelet activation may be a sign of AS exacerbation.

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Acknowledgements

This work was supported by the grant from the Public Health Bureau of Shanghai Municipality (044Y07) and the Sixth Hospital Affiliated to Shanghai Jiaotong University (0239).

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Authors and Affiliations

  1. Department of Nephrology and Rheumatology, the Sixth Hospital Affiliated to Shanghai Jiaotong University, 600 Yishan Road, Shanghai, 200233, China

    Feng Wang, Hai-Yan Xiang & Tao Xing

  2. Department of Internal Medicine, the Hospital Affiliated to Medical College, Shaoxing College of Arts and Science, 260 Chang’an Street, Shaoxing, 312000, China

    Chun-Gen Yan & Nian-Song Wang

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  1. Feng Wang
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  2. Chun-Gen Yan
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  3. Hai-Yan Xiang
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  4. Tao Xing
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  5. Nian-Song Wang
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Correspondence to Feng Wang or Nian-Song Wang.

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Wang, F., Yan, CG., Xiang, HY. et al. The significance of platelet activation in ankylosing spondylitis. Clin Rheumatol 27, 767–769 (2008). https://doi.org/10.1007/s10067-008-0847-7

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  • DOI: https://doi.org/10.1007/s10067-008-0847-7

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