Frequency of HLA-B27 alleles in Brazilian patients with psoriatic arthritis

Abstract

This prospective study analyzed the frequency of HLA-B27 and its alleles in 102 Brazilian patients with psoriatic arthritis (PsA). The association of the HLA-B27 alleles with these variants was compared to a control healthy HLA-B27 positive group of 111 individuals. There was a predominance of male gender (59.8%), Caucasian race (89.2%), and negative HLA-B27 (79.4%) patients. Asymmetric oligoarthritis (62.7%) was the most frequently observed clinical PsA subgroup, followed by spondylitis (16.7%), and polyarthritis (15.7%). Male gender and the spondylitis subgroup were statistically associated to the positive HLA-B27, and the oligoarthritis subgroup was associated to the negative HLA-B27. Among the 21 HLA-B27-positive PsA patients, there was a significant prevalence of the HLA-B*2705 allele (90.5%), similar to that observed in the control group (80.2%); HLA-B*2703 and HLA-B*2707 were statistically associated to the control group.

This is a preview of subscription content, access via your institution.

References

  1. 1.

    Moll JMH, Wright V (1973) Psoriatic arthritis. Semin Arthritis Rheum 3:55–78

    PubMed  Article  CAS  Google Scholar 

  2. 2.

    Gladman DD, Antoni C, Mease P, Clegg DO, Nash P (2005) Psoriatic arthritis: epidemiology, clinical features, course, and outcome. Ann Rheum Dis 65:ii14–ii17

    Article  Google Scholar 

  3. 3.

    Mease P, Goffe B (2005) Diagnosis and treatment of psoriatic arthritis. J Am Acad Rheumatol 52:1–19

    Article  Google Scholar 

  4. 4.

    Gladman DD, Farewell VT, Kopciuk KA, Cook RJ (1998) HLA markers and progression in psoriatic arthritis. J Rheumatol 24:730–733

    Google Scholar 

  5. 5.

    Reveille JD, Ball EJ, Khan MA (2001) HLA-B27 and genetic predisposing factors in spondyloarthropathies. Curr Opin Rheumatol 13:265–72

    PubMed  Article  CAS  Google Scholar 

  6. 6.

    Queiro R, Sarasqueta C, Torre JC, Tinturé T, Lopes-Lagunas I (2001) Comparative analysis of psoriatic spondyloarthropathy between men and women. Rheumatol Int 21:66–68

    PubMed  Article  CAS  Google Scholar 

  7. 7.

    Gladman D, Brubacher B, Buskila D, Langevitz P, Farewell VT (1992) Psoriatic spondyloarthropathy in men and women: a clinical, radiographic, and HLA study. Clin Invest Med 15:371–375

    PubMed  CAS  Google Scholar 

  8. 8.

    Torre-Alonzo JC, Rodriguez-Perez A, Arribas-Castrilho JM, Balina-Garcia J, Riestra-Noriega JL, Lopez-Larrea (1991) Psoriatic arthritis: a clinical, immunological and radiologic study. Br J Rheumatol 30:245–250

    Article  Google Scholar 

  9. 9.

    Veale D, Rogers S, Fitzgerald O (1994) Classification of clinical subsets in psoriatic arthritis. Br J Rheumatol 33:133–138

    PubMed  Article  CAS  Google Scholar 

  10. 10.

    Y-Giien T, Deh-Ming C, Kuo SY, Wang WM, Chen YC, Lai JH (2003) Relationship between human lymphocyte antigen-B27 and clinical features in psoriatic arthritis. J Microbiol Immunol Infect. 36:101–104

    Google Scholar 

  11. 11.

    Njobvu P, McGill P (2000) Psoriatic arthritis and human immunodeficiency virus infection in Zambia. J Rheumatol 27:1699–1702

    PubMed  CAS  Google Scholar 

  12. 12.

    Sampaio-Barros PD, Bertolo MB, Kraemer MHS, Marques-Neto JF, Samara AM (2001) Primary ankylosing spondylitis: patterns of disease in a Brazilian population of 147 patients. J Rheumatol 28:560–565

    PubMed  CAS  Google Scholar 

  13. 13.

    Sampaio-Barros PD, Bertolo MB, Kraemer MHS, Marques-Neto JF, Samara AM (2001) Undifferentiated spondyloarthropathies: a 2-year follow-up study. Clin Rheumatol 20:201–206

    PubMed  Article  CAS  Google Scholar 

  14. 14.

    Marsal S, Armadans-Gil L, Martinez M, Gallardo D, Ribera A, Lience E (1999) Clinical, radiographic and HLA associations as markers for different patterns of psoriatic arthritis. Rheumatology (Oxford) 38:332–337

    Article  CAS  Google Scholar 

  15. 15.

    Queiro R, Sarasqueta C, Belzunequi J, Gonzalez C, Fiqueroa M, Torre-Alonso JC (2002) Psoriatic spondyloarthropathy: A comparative study between HLA-B27 positive and HLA-B27 negative disease. Semin Arthritis Rheum 31:413–418

    PubMed  Article  Google Scholar 

  16. 16.

    Conde RA, Sampaio-Barros PD, Donadi EA et al (2003) Frequency of the HLA-B27 alleles in Brazilian patients with ankylosing spondylitis. J Rheumatol 30:2511–2

    Google Scholar 

  17. 17.

    Sampaio-Barros PD, Conde RA, Donadi EA et al (2003) Undifferentiated spondyloarthropathies in Brazilians: importance of HLA-B27 and the B7-CREG alleles in characterization and disease progression. J Rheumatol 30:2632–2637

    PubMed  CAS  Google Scholar 

  18. 18.

    Armas JB, Gonzalez S, Martinez-Borra J et al (1999) Susceptibility to ankylosing spondylitis is independent of the Bw4 and Bw6 epitopes of HLA-B27 allele. Tissue Antigens 53:237–243

    PubMed  Article  CAS  Google Scholar 

  19. 19.

    Montserrat V, Marti M, Lopez de Castro JA (2003) Allospecific T cell epitope sharing reveals extensive conservation of the antigenic features of peptide ligands among HLA-B27 subtypes differentially associated with spondyloarthritis. J Immunol 170:5778–85

    PubMed  CAS  Google Scholar 

Download references

Acknowledgements

This study was financially supported by a grant from FAPESP (Fundo de Amparo à Pesquisa do Estado de São Paulo).

Author information

Affiliations

Authors

Corresponding author

Correspondence to Rubens Bonfiglioli.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bonfiglioli, R., Conde, R.A., Sampaio-Barros, P.D. et al. Frequency of HLA-B27 alleles in Brazilian patients with psoriatic arthritis. Clin Rheumatol 27, 709–712 (2008). https://doi.org/10.1007/s10067-007-0770-3

Download citation

Keywords

  • B27-Human histocompatibility antigen
  • B*27 alleles
  • Psoriatic Arthritis