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Pericarditis: a rare complication of methotrexate therapy

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Abstract

Serositis is a rare complication of methotrexate (MTX) administration. We report a 60-year-old man with rheumatoid arthritis who developed pericarditis after taking his weekly MTX dose, which recurred within hours after 2 subsequent weekly MTX doses. Pericarditis has not recurred after discontinuance of MTX over 3 years ago. We conclude that he had MTX-induced pericarditis, based on the close temporal relationship between MTX ingestion and manifestations of pericarditis on three distinct occasions because of the previous reports of MTX-induced pericarditis and because pericarditis has not recurred after MTX withdrawal.

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Authors and Affiliations

  1. MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA

    Tayyab Mohyuddin, Mazen Elyan & Irving Kushner

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  1. Tayyab Mohyuddin
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  2. Mazen Elyan
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  3. Irving Kushner
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Correspondence to Irving Kushner.

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Mohyuddin, T., Elyan, M. & Kushner, I. Pericarditis: a rare complication of methotrexate therapy. Clin Rheumatol 26, 2157–2158 (2007). https://doi.org/10.1007/s10067-007-0630-1

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  • DOI: https://doi.org/10.1007/s10067-007-0630-1

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