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Estrogen receptor expression by peripheral blood mononuclear cells of patients with systemic lupus erythematosus

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Abstract

To investigate the influence of sex hormones on the development of systemic lupus erythematosus (SLE), we examined the estrogen receptor (ER) expression by peripheral blood mononuclear cells (PBMC) in patients with SLE using the real-time quantitative polymerase chain reaction (TaqMan) method. The expression of messenger RNA (mRNA) for ER alpha (ERa) was increased and expression of ER beta (ERb) mRNA was decreased in PBMC from SLE patients compared with PBMC from normal controls. These findings may be useful for elucidation of the pathophysiology of SLE.

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Acknowledgment

This work was supported by the grants from The Institute for Environment and Gender-Specific Medicine, Juntendo University Graduate School of Medicine. We would like to thank heartily the technical assistance of Ms. Chika Tanaka.

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Authors and Affiliations

  1. Department of General Medicine, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan

    Akihiro Inui, Toshio Naito & Yasuo Hayashida

  2. Department of Internal Medicine and Rheumatology, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan

    Hitoshi Ogasawara & Yoshinari Takasaki

  3. Department of Internal Medicine, Juntendo University Urayasu Hospital, Urayasu-shi, Chiba, 279-0021, Japan

    Iwao Sekigawa

  4. Institute for Environmental and Gender Specific Medicine, 2-1-1 Tomioka, Urayasu-shi, Chiba, 279-0021, Japan

    Iwao Sekigawa, Kenji Takamori & Hideoki Ogawa

Authors
  1. Akihiro Inui
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  2. Hitoshi Ogasawara
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  3. Toshio Naito
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  4. Iwao Sekigawa
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  5. Yoshinari Takasaki
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  6. Yasuo Hayashida
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  7. Kenji Takamori
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  8. Hideoki Ogawa
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Correspondence to Iwao Sekigawa.

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Inui, A., Ogasawara, H., Naito, T. et al. Estrogen receptor expression by peripheral blood mononuclear cells of patients with systemic lupus erythematosus. Clin Rheumatol 26, 1675–1678 (2007). https://doi.org/10.1007/s10067-007-0568-3

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  • DOI: https://doi.org/10.1007/s10067-007-0568-3

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