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Anti-p53 antibodies in patients with dermatomyositis/polymyositis

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Abstract

Dermatomyositis/polymyositis (DM/PM), which is often accompanied by various immunological abnormalities, was reported to be associated with an increased incidence of malignancies. In this study, we analyzed serum levels of anti-p53 antibody (anti-p53 Ab) in DM/PM patients and in normal controls. Serum levels of anti-p53 Abs were significantly higher in DM/PM patients than those in healthy controls. However, there was no significant difference between serum levels in patients with malignancies and those in patients without malignancies. Anti-p53 Abs were positive in 13% (4 out of 31) of the DM/PM patients. Of these four patients, only one had an internal malignancy. Immunoglobulin G levels were significantly higher in patients positive for anti-p53 Ab than those who were not. These results seemed to suggest that the presence of anti-p53 Abs in DM/PM patients is due to immunological abnormalities in this disease.

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Authors and Affiliations

  1. Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Yoshihiro Mimura, Norihito Yazawa, Zenshirou Tamaki, Ryuichi Ashida, Masatoshi Jinnin, Yoshihide Asano, Yayoi Tada, Masahide Kubo & Kunihiko Tamaki

  2. Department of Dermatology and Plastic and Reconstructive Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan

    Hironobu Ihn

Authors
  1. Yoshihiro Mimura
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  2. Norihito Yazawa
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  3. Zenshirou Tamaki
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  4. Ryuichi Ashida
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  5. Masatoshi Jinnin
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  6. Yoshihide Asano
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  7. Yayoi Tada
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  8. Masahide Kubo
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  9. Hironobu Ihn
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  10. Kunihiko Tamaki
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Corresponding author

Correspondence to Norihito Yazawa.

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Mimura, Y., Yazawa, N., Tamaki, Z. et al. Anti-p53 antibodies in patients with dermatomyositis/polymyositis. Clin Rheumatol 26, 1328–1331 (2007). https://doi.org/10.1007/s10067-006-0473-1

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  • DOI: https://doi.org/10.1007/s10067-006-0473-1

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