References
Singh YP, Aggarwal A, Misra R, Agarwal V (2006) Low-dose methotrexate-induced pancytopenia. Clin Rheumatol (in press). DOI 10.1007/s10067-006-0301-7
Williams WM, Chen TS, Huang KC (1984) Effect of penicillin on the renal tubular secretion of methotrexate in the monkey. Cancer Res 44:1913–1917
Bloom EJ, Ignoffo RJ, Reis CA, Cadman E (1986) Delayed clearance of methotrexate associated with antibiotics and anti inflammatory agents. Clin Res 34:560A
Ronchera CL, Hernandez T, Peris JE et al (1993) Pharmacokinetic interaction between high dose methotrexate and amoxycillin. Ther Drug Monit 15:375–379
Mayall B, Poggi G, Parkin JD (1991) Neutropenia due to low dose methotrexate therapy for psoriasis and rheumatoid arthritis may be fatal. Med J Aust 155:480–484
Kahn SB, Fein SA, Brodsky I (1968) Effects of trimethoprim on folate metabolism in man. Clin Pharmacol Ther 9:550–560
Jenkins GC, Hughes DTD, Hall PC (1970) A haematological study of patients receiving long-term treatment with trimethoprim and sulphonamide J Clin Pathol 23(5):392–396
Sive J, Green R, Metz J (1972) Effect of trimethoprim on folate-dependent DNA synthesis in human bone marrow. J Clin Pathol 25:194–197
Blackwell EA, Hawson GAT, Leer J, Bain B (1978) Acute pancytopenia due to megaloblastic arrest in association with co-trimoxazole. Med J Aust 2(1):38–41 (Jul 1)
Stimmesse B, Daoudal P, Boillot A, Rozenbaum A, Barale F (1979) Fatal pancytopenia associated with sulfamethoxazole-trimethoprim therapy (author’s transl). Anesth Analg (Paris) 36(11–12):565–566
Maricic M, Davis M, Gall EP (1986) Megaloblastic pancytopenia in a patient receiving concurrent methotrexate and trimethoprim–sulfamethoxazole treatment. Arthritis Rheum 29(1):133–135 (Jan)
Thomas MH, Gutterman LA (1986) Methotrexate toxicity in a patient receiving trimethoprim–sulfamethoxazole. J Rheumatol 13(2):440–441 (Apr)
Ng HWK, Macfarlane AW, Graham RM, Verbov JL (1987) Near fatal drug interactions with methotrexate given for psoriasis. Br Med J 295(6601):752–753 (Sep 26)
Thomas DR, Dover JS, Camp RDR (1987) Pancytopenia induced by the interaction between methotrexate and trimethoprim–sulfamethoxazole. J Am Acad Dermatol 17(6):1055–1056 (Dec)
Jeurissen ME, Boerbooms AM, van de Putte LB (1989) Pancytopenia and methotrexate with trimethoprim–sulfamethoxazole. Ann Intern Med 111(3):261 (Aug 1)
Groenendal H, Rampen FH (1990) Methotrexate and trimethoprim–sulphamethoxazole—a potentially hazardous combination. Clin Exp Dermatol 15(5):358–360 (Sep)
Liddle BJ (1991) Methotrexate interactions. Clin Exp Dermatol 16(4):311–312 Jul
Govert JA, Patton S, Fine RL (1992) Pancytopenia from using trimethoprim and methotrexate. Ann Intern Med 117(10):877–878 (Nov 15)
Chevrel G, Brantus JF, Sainte-Laudy J, Miossec P (1999) Allergic pancytopenia to trimethoprim–sulphamethoxazole for Pneumocystis carinii pneumonia following methotrexate treatment for rheumatoid arthritis. Rheumatology (Oxford) 38(5):475–476 (May)
Al-Awadhi A, Dale P, McKendry RJR (1993) Pancytopenia associated with low dose methotrexate therapy. A regional survey. J Rheumatol 20(7):1121–1125 (Jul)
Kitsuwa S, Matsunaga K, Kawai M, Tsuzi T, Kato K, Tani K, Okubo T (1996) Pancytopenia and Pneumocystis carinii pneumonia associated with low dose methotrexate pulse therapy for rheumatoid arthritis—case report and review of literature. Ryumachi 36:551–558 (Jun)
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Sathi, N., Dawson, J. Methotrexate-induced pancytopenia associated with co-prescription of penicillin and trimethoprim. Clin Rheumatol 26, 134–135 (2007). https://doi.org/10.1007/s10067-006-0423-y
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DOI: https://doi.org/10.1007/s10067-006-0423-y