Skip to main content

Advertisement

Log in

Methotrexate-induced pancytopenia associated with co-prescription of penicillin and trimethoprim

  • Letter to the Editor
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Singh YP, Aggarwal A, Misra R, Agarwal V (2006) Low-dose methotrexate-induced pancytopenia. Clin Rheumatol (in press). DOI 10.1007/s10067-006-0301-7

  2. Williams WM, Chen TS, Huang KC (1984) Effect of penicillin on the renal tubular secretion of methotrexate in the monkey. Cancer Res 44:1913–1917

    PubMed  CAS  Google Scholar 

  3. Bloom EJ, Ignoffo RJ, Reis CA, Cadman E (1986) Delayed clearance of methotrexate associated with antibiotics and anti inflammatory agents. Clin Res 34:560A

    Google Scholar 

  4. Ronchera CL, Hernandez T, Peris JE et al (1993) Pharmacokinetic interaction between high dose methotrexate and amoxycillin. Ther Drug Monit 15:375–379

    Article  PubMed  CAS  Google Scholar 

  5. Mayall B, Poggi G, Parkin JD (1991) Neutropenia due to low dose methotrexate therapy for psoriasis and rheumatoid arthritis may be fatal. Med J Aust 155:480–484

    PubMed  CAS  Google Scholar 

  6. Kahn SB, Fein SA, Brodsky I (1968) Effects of trimethoprim on folate metabolism in man. Clin Pharmacol Ther 9:550–560

    PubMed  CAS  Google Scholar 

  7. Jenkins GC, Hughes DTD, Hall PC (1970) A haematological study of patients receiving long-term treatment with trimethoprim and sulphonamide J Clin Pathol 23(5):392–396

    PubMed  CAS  Google Scholar 

  8. Sive J, Green R, Metz J (1972) Effect of trimethoprim on folate-dependent DNA synthesis in human bone marrow. J Clin Pathol 25:194–197

    PubMed  CAS  Google Scholar 

  9. Blackwell EA, Hawson GAT, Leer J, Bain B (1978) Acute pancytopenia due to megaloblastic arrest in association with co-trimoxazole. Med J Aust 2(1):38–41 (Jul 1)

    PubMed  CAS  Google Scholar 

  10. Stimmesse B, Daoudal P, Boillot A, Rozenbaum A, Barale F (1979) Fatal pancytopenia associated with sulfamethoxazole-trimethoprim therapy (author’s transl). Anesth Analg (Paris) 36(11–12):565–566

    CAS  Google Scholar 

  11. Maricic M, Davis M, Gall EP (1986) Megaloblastic pancytopenia in a patient receiving concurrent methotrexate and trimethoprim–sulfamethoxazole treatment. Arthritis Rheum 29(1):133–135 (Jan)

    Article  PubMed  CAS  Google Scholar 

  12. Thomas MH, Gutterman LA (1986) Methotrexate toxicity in a patient receiving trimethoprim–sulfamethoxazole. J Rheumatol 13(2):440–441 (Apr)

    PubMed  CAS  Google Scholar 

  13. Ng HWK, Macfarlane AW, Graham RM, Verbov JL (1987) Near fatal drug interactions with methotrexate given for psoriasis. Br Med J 295(6601):752–753 (Sep 26)

    Article  CAS  Google Scholar 

  14. Thomas DR, Dover JS, Camp RDR (1987) Pancytopenia induced by the interaction between methotrexate and trimethoprim–sulfamethoxazole. J Am Acad Dermatol 17(6):1055–1056 (Dec)

    Article  PubMed  CAS  Google Scholar 

  15. Jeurissen ME, Boerbooms AM, van de Putte LB (1989) Pancytopenia and methotrexate with trimethoprim–sulfamethoxazole. Ann Intern Med 111(3):261 (Aug 1)

    PubMed  CAS  Google Scholar 

  16. Groenendal H, Rampen FH (1990) Methotrexate and trimethoprim–sulphamethoxazole—a potentially hazardous combination. Clin Exp Dermatol 15(5):358–360 (Sep)

    Article  PubMed  CAS  Google Scholar 

  17. Liddle BJ (1991) Methotrexate interactions. Clin Exp Dermatol 16(4):311–312 Jul

    Article  PubMed  CAS  Google Scholar 

  18. Govert JA, Patton S, Fine RL (1992) Pancytopenia from using trimethoprim and methotrexate. Ann Intern Med 117(10):877–878 (Nov 15)

    PubMed  CAS  Google Scholar 

  19. Chevrel G, Brantus JF, Sainte-Laudy J, Miossec P (1999) Allergic pancytopenia to trimethoprim–sulphamethoxazole for Pneumocystis carinii pneumonia following methotrexate treatment for rheumatoid arthritis. Rheumatology (Oxford) 38(5):475–476 (May)

    Article  CAS  Google Scholar 

  20. Al-Awadhi A, Dale P, McKendry RJR (1993) Pancytopenia associated with low dose methotrexate therapy. A regional survey. J Rheumatol 20(7):1121–1125 (Jul)

    PubMed  CAS  Google Scholar 

  21. Kitsuwa S, Matsunaga K, Kawai M, Tsuzi T, Kato K, Tani K, Okubo T (1996) Pancytopenia and Pneumocystis carinii pneumonia associated with low dose methotrexate pulse therapy for rheumatoid arthritis—case report and review of literature. Ryumachi 36:551–558 (Jun)

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Navtej Sathi.

Additional information

This letter refers to the article available at: http://dx.doi.org/10.1007/s10067-006-0301-7.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sathi, N., Dawson, J. Methotrexate-induced pancytopenia associated with co-prescription of penicillin and trimethoprim. Clin Rheumatol 26, 134–135 (2007). https://doi.org/10.1007/s10067-006-0423-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-006-0423-y

Keywords

Navigation