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Inflammatory myositis complicating hypocomplementemic urticarial vasculitis despite on-going immunosuppression

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Abstract

We present a patient with previously diagnosed hypocomplementemic urticarial vasculitis syndrome, with skin, lung, and renal involvement, who presented with congestive cardiac failure. During the course of her hospitalization, she was also found to have profound proximal muscle weakness in both upper and lower limbs associated with raised creatinine kinase levels. A muscle biopsy was performed, which demonstrated evidence of an inflammatory myositis with vasculitis, which had returned despite on-going immunosuppression. This occurrence of a new autoimmune disease may well be an example of the “waste disposal” hypothesis.

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References

  1. McDuffie FC, Sams WM Jr, Maldonado JE, Andreini IPH, Conn DL, Samayoa EA (1973) Hypocomplementemia with cutaneous vasculitis and arthritis. Mayo Clin Proc 48:340–348

    PubMed  CAS  Google Scholar 

  2. Stone JH (2001) Polyarteritis nodosa, microscopic polyangiitis and small vessel vasculitides. In: Klippel JH (ed) Primer on the rheumatic diseases, 12th edn. Arthritis Foundation, Atlanta, USA, pp 385–391

    Google Scholar 

  3. Wisnieski JJ, Baer AN, Christensen J, Cupps TR et al (1995) Hypocomplementemic urticarial vasculitis syndrome: clinical and serological findings in 18 patients. Medicine (Baltimore) 74:24–41

    Article  CAS  Google Scholar 

  4. Feig PU, Soter NA, Yager HM, Caplan L, Rosen S (1976) Vasculitis with urticaria, hypocomplementemia, and multiple system involvement. JAMA 236(18):2065–2068

    Article  PubMed  CAS  Google Scholar 

  5. Callen JP, Dubin HV (1978) Urticaria and polymyositis. Arch Dermatol 114:1545–1546

    Article  PubMed  CAS  Google Scholar 

  6. Manderson AP, Botto M, Walport MJ (2004) The role of complement in the development of systemic lupus erythematosus. Annu Rev Immunol 22:431–456

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Immunology, The Canberra Hospital, Woden, Australian Capital Territory, Australia

    Gary Y. J. Chew & Paul A. Gatenby

  2. Australian National University Medical School, Canberra, Australia

    Paul A. Gatenby

Authors
  1. Gary Y. J. Chew
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  2. Paul A. Gatenby
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Correspondence to Gary Y. J. Chew.

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Chew, G.Y.J., Gatenby, P.A. Inflammatory myositis complicating hypocomplementemic urticarial vasculitis despite on-going immunosuppression. Clin Rheumatol 26, 1370–1372 (2007). https://doi.org/10.1007/s10067-006-0397-9

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  • DOI: https://doi.org/10.1007/s10067-006-0397-9

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