Abstract
In Löfgren’s syndrome, pain and swelling commonly involves the ankle joints. In this prospective case series, the magnetic resonance imaging findings of ankle joint involvement are described. Extensive subcutaneous and soft tissue oedema was commonly seen around the ankles. Bone, cartilage, ligaments and tendons were typically uninvolved. Small amounts of joint and tenosynovial fluid were present without evidence of synovial thickening or synovitis. The fluid is probably reactive to adjacent inflammation in the para-articular soft tissues and probably not representing a primary site of involvement. These findings demonstrate that the arthritis in Löfgren’s syndrome stems primarily from periarthritis. This is consistent with prior descriptions using ultrasonography.
References
Löfgren S, Lundback H (1952) The bilateral hilar lymphoma syndrome. A study of the relation to age and sex in 212 cases. Acta Med Scand 142:259–264
Mana J, Gomez-Vaquero C, Salazar A et al (1996) Periarticular ankle sarcoidosis: a variant of Löfgren’s syndrome. J Rheumatol 23(5):874–877
Schumacher RH (1972) Sarcoidosis. In: Hollander JL (ed) Arthritis and allied conditions. A textbook of Rheumatology. Lea and Febiger, pp 1295–1302
Kellner H, Spathling S, Herzer P (1992) Ultrasound findings in Löfgren’s: is ankle swelling caused by arthritis, tenosynovitis or periarthritis? J Rheumatol 19(1):38–41
Jacobson J, Andresen R, Jaovisidha S et al (1998) Detection of ankle effusions: comparison study in cadavers using radiography, sonography, and MR imaging. Am J Roentgenol 170(50):1231–1238
Cantini F, Niccoli L, Olivieri I et al (1997) Remitting distal lower extremity swelling with pitting oedema in acute sarcoidosis. Ann Rheum Dis 56(9):565–566
Mana J, Gomez-Vaquero C, Montero A et al (1999) Löfgren’s syndrome revisited: a study of 186 patients. Am J Med 107(3):240–245
Kremer JM (1986) Histologic findings in siblings with acute sarcoid arthritis: association with the B8, DR3 phenotype. J Rheumatol 13(3):593–597
Molina JF, Gedalia A, Espinoza LR (1997) Periarticular ankle sarcoidosis: a variant of Löfgren’s syndrome. J Rheumatol 24(1):239
Acknowledgements
The authors acknowledge the contribution of Dr Nisha Karunaratne, Radiology Department, Westmead Hospital for preparing the images. All authors contributed to the authorship of this paper.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Anandacoomarasamy, A., Peduto, A., Howe, G. et al. Magnetic resonance imaging in Löfgren’s syndrome: demonstration of periarthritis. Clin Rheumatol 26, 572–575 (2007). https://doi.org/10.1007/s10067-006-0360-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10067-006-0360-9