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Rheumatoid factor isotypes in mixed connective tissue disease

Clinical Rheumatology volume 25, pages 572–574 (2006)Cite this article

Abstract

Mixed connective tissue disease (MCTD) is a connective tissue disorder that is often accompanied by various immunological abnormalities. In this study, we analyzed serum levels of rheumatoid factor (RF) isotypes in patients with MCTD and in normal controls to determine if any of these isotypes reflects the severity of the disease. IgM-RF, IgG-RF, and IgA-RF were positive in 48, 38, and 33% of the patients, respectively. The frequency of positive anti-SS-A antibody and decrease in white blood cell counts were significantly greater in patients with elevated IgA-RF levels than that in those with normal levels. These results suggest that the presence of RF isotypes can be regarded as one of the various immunological abnormalities of MCTD.

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References

  1. Sharp GC, Irvin WS, Tan EM et al (1972) Mixed connective tissue disease—an apparently distinct rheumatic disease syndrome with a specific antibody to an extractable nuclear antigen (ENA). Am J Med 52:148–159

    Article  PubMed  CAS  Google Scholar 

  2. Stankaitiene DJ, Matulis AA, Guobys H et al (1978) Serum anti-immunoglobulins reactive with human and rabbit IgG in rheumatoid arthritis and other conditions. Arthritis Rheum 21:120–128

    PubMed  Article  CAS  Google Scholar 

  3. Lessard J, Nunnery E, Cecere F et al (1983) Relationship between the articular manifestation of rheumatoid arthritis and circulating immune complexes detected by three methods and specific classes of rheumatoid factors. J Rheumatol 10:411–417

    PubMed  CAS  Google Scholar 

  4. Silvestris KB, Goodwin JS, Williams RC Jr (1985) IgM, IgA and IgG rheumatoid factors in patients with rheumatoid arthritis and normal donors. Clin Rheumatol 4:392–398

    Article  PubMed  CAS  Google Scholar 

  5. Eberhardt KB, Svensson L, Truedsson L et al (1988) The occurrence of rheumatoid factor isotypes in early definite rheumatoid arthritis—no relationship with erosion or disease activity. J Rheumatol 15:1070–1074

    PubMed  CAS  Google Scholar 

  6. Eberhardt KB, Truedsson L, Pettersson H et al (1990) Disease activity and joint damage progression in early rheumatoid arthritis: relation to IgG, IgA and IgM rheumatoid factor. Ann Rheum Dis 49:906–909

    PubMed  CAS  Article  Google Scholar 

  7. Eggelmijer F, Otten HG, de Rooy HH et al (1990) Significance of rheumatoid factor isotypes in seronegative rheumatoid arthritis. Rheumatol Int 10:43–46

    Article  PubMed  Google Scholar 

  8. Carson DA (1993) Rheumatoid factor in Crohn’s disease. In: Kelly WN, Harris ED, Ruddy S, Sledge CB (eds) Textbook of rheumatology, 4th edn. Saunders, Philadelphia

  9. Ihn H, Sato S, Fujimoto M et al (1996) Measurement of anticardiolipin antibodies by ELISA using β2-glycoprotein I (β2-GPI) in systemic sclerosis. Clin Exp Immunol 37:1188–1192

    Google Scholar 

  10. Ezaki I, Sakata H, Iwamoto Y (1990) A study of clinical evaluation of a new IgG-RF assay kit (ED001): its usefulness as an indicator for the determination of RA disease activity. Igaku To Yakugaku 24:441–448

    Google Scholar 

  11. Fujimatsu J, Satoh T, Koide A et al (1990) Establishment of IgG-RF detection system by enzyme-linked immunosorbent assay. Rheumati Ka 4:112–124

    Google Scholar 

  12. Garcia-de la Torre I, Salazar-Paramo M, Salmon-de la Torre G (1996) Mixed connective tissue disease. A clinico-serological study of 17 cases. Mol Biol Rep 23:153–157

    Article  PubMed  CAS  Google Scholar 

  13. Mimura Y, Ihn H, Jinnin M et al (2004) Rheumatoid factor isotypes and anti-agalactosyl IgG antibodies in systemic sclerosis. Br J Dermatol 151:803–808

    Article  PubMed  CAS  Google Scholar 

  14. Ichikawa Y, Yamada C, Horiki T et al (1998) Anti-agalactosyl IgG antibodies and isotype profiles of rheumatoid factors in Sjögren’s syndrome and rheumatoid arthritis. Clin Exp Rheumatol 16:709–715

    PubMed  CAS  Google Scholar 

  15. Ramos-Niembro F, Alarcon-Segovia D, Hernandez-Ortiz J (1979) Articular manifestations of mixed connective tissue disease. Arthritis Rheum 22:43–51

    PubMed  Article  CAS  Google Scholar 

  16. Sharp GC, Singsen BH (1993) Mixed connective tissue disease. In: MacCarty DJ, Koopman WJ (eds) Arthritis and allied conditions, 12th edn. Lea & Febiger, Philadelphia, pp 1213–1224

    Google Scholar 

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Affiliations

  1. Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Yoshihiro Mimura, Hironobu Ihn, Masatoshi Jinnin, Yoshihide Asano, Kenichi Yamane & Kunihiko Tamaki

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  1. Yoshihiro Mimura
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  2. Hironobu Ihn
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  3. Masatoshi Jinnin
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  4. Yoshihide Asano
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  5. Kenichi Yamane
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  6. Kunihiko Tamaki
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Correspondence to Hironobu Ihn.

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Mimura, Y., Ihn, H., Jinnin, M. et al. Rheumatoid factor isotypes in mixed connective tissue disease. Clin Rheumatol 25, 572–574 (2006). https://doi.org/10.1007/s10067-005-0185-y

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  • DOI: https://doi.org/10.1007/s10067-005-0185-y

Keywords

  • Enzyme-linked immunosorbent assay
  • Mixed connective tissue disease
  • Rheumatoid factor isotypes