Abstract
Wegener’s granulomatosis (WG) and sarcoidosis are two distinct granulomatous diseases characterized by multisystem involvement. We report a patient who initially presented with symptoms of limited WG predominantly affecting the nose, followed by a facial rash, which was histologically proven to be due to sarcoidosis. The sequential development of these two diseases in one patient is very rare, and to our knowledge, only one such case has been reported in the last 50 years (Am J Kidney Dis 28:893–898, 1996).
References
Ahuja TS, Mattaria J, Valderrama E, Sankaran R, Singhal PC, Wagner JD (1996) Wegener’s granulomatosis followed by development of sarcoidosis. Am J Kidney Dis 28:893–898
Fernandes SRM, Singsen BH, Hoffman GS (2000) Sarcoidosis and systemic vasculitis. Semin Arthritis Rheum 30:33–46
DeRemee RA (1994) Sarcoidosis and Wegener’s granulomatosis: a comparative analysis. Sarcoidosis 11:7–18
Csernock E, Trabandt A, Muller A, Wang GC et al (1999) Cytokine profiles in Wegener’s granulomatosis: predominance of type 1 (Th1) in the granulomatous inflammation. Arthritis Rheum 42:742–750
Lamprecht P, Moosig F, Csernock E, Seitzer U et al (2001) CD28 negative T cells are recruited into granulomatous lesions of the respiratory tract in Wegener’s granulomatosis. Thorax 56:751–757
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kuttikat, A., Saeed, T., Chopra, B. et al. Nasal Wegener’s and skin sarcoid—a rare combination of two granulomatous diseases. Clin Rheumatol 25, 895–897 (2006). https://doi.org/10.1007/s10067-005-0087-z
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10067-005-0087-z