Abstract
Aortic valve lesions are often found in patients with rheumatic diseases, but their clinical significance has not been properly evaluated. In the present study, the echocardiographic files of the cardiology unit of the Oulu University Hospital were screened for a diagnosis of aortic insufficiency (AI). The aetiology of the valve disease and specific details of the rheumatic disease were evaluated in 160 patients. Twenty-eight patients (18%) had a history of rheumatic fever. Rheumatic disease was found in 14 patients (8.8%) with AI, which is significantly more than the prevalence of rheumatic diseases (1.8%) in the corresponding age group (35–100 years) in Finland. Rheumatoid arthritis or juvenile rheumatoid arthritis was found in seven patients (4.4%), whereas ankylosing spondylitis or seronegative spondylarthropathy were found in four patients (2.5%). Other rheumatic diseases included Takayasu's arteritis (two patients) and scleroderma (one patient). When 38 patients with pure AI without other possible aetiology were analysed, rheumatic disease was found in five patients (13%). Patients with rheumatic disease as a potential aetiology of AI often had symptomatic valve disease, which required surgical treatment, although great differences between different aetiologies were not found.
Similar content being viewed by others
References
Rapaport E, Rackley CE, Cohn LH (1994) Aortic valve disease. In: Schlant RC, Alexander RW (eds) Hurst's The heart, 8th edn. McGraw-Hill, New York, pp 1457–1481
LaBresh KA, Lally EV, Sharma SC, Ho G Jr (1985) Two-dimensional echocardiographic detection of preclinical aortic root abnormalities in rheumatoid variant diseases. Am J Med 78:908–912
Sukenik S, Pras A, Buskila D, Katz A, Snir Y, Horowitz J (1987) Cardiovascular manifestations of ankylosing spondylitis. Clin Rheumatol 6:588–592
O'Neill TW, King G, Graham IM, Molony J, Bresnihan B (1992) Echocardiographic abnormalities in ankylosing spondylitis. Ann Rheum Dis 51:652–654
Roldan CA, Chavez J, Wiest PW, Qualls CR, Crawford MH (1998) Aortic root disease and valve disease associated with ankylosing spondylitis. J Am Coll Cardiol 32:1397–1404
Qaiyumi S, Hassan ZU, Toone E (1985) Seronegative spondylarthropathies in lone aortic insufficiency. Arch Intern Med 145:822–824
Bergfeldt L (1997) HLA-B27-associated cardiac disease. Ann Intern Med 127:621–629
Bergfeldt L, Insulander P, Lindblom D, Moller E, Edhag O (1988) HLA-B27: an important genetic risk factor for lone aortic regurgitation and severe conduction system abnormalities. Am J Med 85:12–18
Olson LJ, Subramanian R, Edwards WD (1984) Surgical pathology of pure aortic insufficiency: a study of 225 cases. Mayo Clin Proc 59:835–841
Jimenez-Balderas FJ, Garcia-Rubi D, Perez-Hinojosa S, Arellano J, Yanez P, Sanchez ML, Camargo-Coronel A, Zonana-Nacach A (2001) Two-dimensional echo Doppler findings in juvenile and adult onset ankylosing spondylitis with long-term disease. Angiology 52:543–548
Bulkley B, Robers W (1973) Ankylosing spondylitis and aortic regurgitation. Description of the characteristic cardiovascular lesion from study of eight necropsy patients. Circulation 48:1014–1027
Waller B, Howard J, Fess S (1994) Pathology of aortic valve stenosis and pure aortic regurgitation. A clinical morphologic assessment—Part II. Clin Cardiol 17:150–156
Toumanidis ST, Papamichael CM, Antoniades LG, Pantelia MI, Saridakis NS, Mavrikakis ME, Sideris DA, Moulopoulos SD (1995) Cardiac involvement in collagen diseases. Eur Heart J 16:257–262
Chand EM, Freant LJ, Rubin JW (1999) Aortic valve rheumatoid nodules producing clinical aortic regurgitation and a review of the literature. Cardiovasc Pathol 8:333–338
Townend JN, Emery P, Davies MK, Littler WA (1991) Acute aortitis and aortic incompetence due to systemic rheumatological disorders. Int J Cardiol 33:253–258
Corrao S, Salli L, Arnone S, Scaglione R, Amato V, Cecala M, Licata A, Licata G (1995) Cardiac involvement in rheumatoid arthritis: evidence of silent heart disease. Eur Heart J 16:253–256
Wislowska M, Sypula S, Kowalik I (1999) Echocardiographic findings and 24-h electrocardiographic Holter monitoring in patients with nodular and non-nodular rheumatoid arthritis. Rheumatol Int 18:163–169
Camilleri JP, Douglas-Jones AG, Pritchard MH (1991) Rapidly progressive aortic valve incompetence in a patient with rheumatoid arthritis. Br J Rheumatol 30:379–381
Levine AJ, Dimitri WR, Bonser RS (1999) Aortic regurgitation in rheumatoid arthritis necessitating aortic valve replacement. Eur J Cardiothorac Surg 15:213–214
Huppertz H-I, Voigt I, Müller-Scholden J, Sandhage K (2000) Cardiac manifestations in patients with HLA B27-associated juvenile arthritis. Pediatr Cardiol 21:141–147
Ando M, Kosakai Y, Okita Y, Matsukawa R, Takamoto S (1999) Surgical treatment for aortic regurgitation caused by non-specific aortitis. Cardiovasc Surg 7:409–413
Moro H, Hayashi J, Ohzeki H, Sogawa M, Nakayama T, Namura O (1999) Surgical management of cardiovascular lesions caused by systemic inflammatory diseases. Thorac Cardiovasc Surg 47:106–110
Roldan CA, Shively BK, Crawford MH (1996) An echocardiographic study of valvular heart disease associated with systemic lupus erythematosus. N Engl J Med 335:1424–1430
Omdal R, Lunde P, Rasmussen K, Mellgren SI, Husby G (2001) Transesophageal and transthoracic echocardiography and Doppler-examinations in systemic lupus erythematosus. Scand J Rheumatol 275–281
De Clerck LS, Meijers KA, Cats A (1989) Is MCTD a distinct entity? Comparison of clinical and laboratory findings in MCTD, SLE, PSS, and RA patients. Clin Rheumatol 8:29–36
Yunus MB, Radford CM, Masi AT, Zimmerman TJ, Calabro JJ, Miller KA (1984) Aortic regurgitation in scleroderma. J Rheumatol 11:384–386
Penmetcha M, Rosenbush SW, Harris CA (1996) Cardiac valvular disease in scleroderma and systemic lupus erythematosus/scleroderma overlap associated with antiphospholipid antibodies. J Rheumatol 23:2171–2174
Tsuji M, Nakatami T, Nojiri T, Nishio H, Shima H, Hiroi Y, Ueno Y, Nishio I, Masuyama Y (1986) A case of Sjogren's syndrome with valvular diseases. Jpn Heart J 27:137–143
Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang M, Luthra HS et al (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324
Van der Linden S, Valkenburg HA, Cats A (1984) Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum 27:361–368
Dougados M, van der Linde SM, Juhlin R, Huitfeldt B, Amor B, Calin A, Cats A, Dijkmans B, Olivieri I, Pasero G (1991) The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy. Arthritis Rheum 34:1218–1227
Kansaneläkelaitoksen tilastollinen vuosikirja 2003. Kansaneläkelaitoksen julkaisuja T1:39 (Finnish)
Hakala M, Pöllänen R, Nieminen P (1993) The ARA 1987 revised criteria select patients with clinical rheumatoid arthritis from a population based cohort of subjects with chronic rheumatic diseases registered for drug reimbursement. J Rheumatol 20:1674–1678
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Uusimaa, P., Krogerus, ML., Airaksinen, J. et al. Aortic valve insufficiency in patients with chronic rheumatic diseases. Clin Rheumatol 25, 309–313 (2006). https://doi.org/10.1007/s10067-005-0006-3
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10067-005-0006-3