Abstract
The objective of this study was to evaluate the early damage as measured by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SLICC/ACR DI) in Brazilian systemic lupus erythematosus (SLE) patients with disease duration of 2 and 3 years and to evaluate the possible association between SLICC/ACR DI score and sociodemographic and clinical data. The SLICC/ACR DI was measured in 54 patients with SLE according to the ACR criteria for SLE and a mean (SD) disease duration of 29 (3.8) months. The patients were provided by outpatient clinics and hospitals of the public health network and private clinics in the city of Natal in Brazil. The SLICC/ACR DI scores for each type of organ damage, prevalence of damage within organ systems, and the association with sociodemographic variables were assessed. Disease duration was considered as the time from diagnosis until the study. Organ damage was present in 18 (33%) of the 54 patients while 36 patients (67%) had no damage. The skin (11%), renal (9%), and pulmonary (7.4%) systems were the most frequently involved, followed by the neuropsychiatric and musculoskeletal systems, premature gonadal failure, and diabetes. The most frequent individual items on the SLICC/ACR DI were scarring chronic alopecia and pleural fibrosis. No association was demonstrated between organ damage (SLICC/ACR scores) and sociodemographic and clinical variables. Early organ damage demonstrated in Brazilian patients with SLE was similar to other populations studied in the world, despite a low socioeconomic status. In contrast to reports in other studies, a cutaneous lesion was the most frequent cause of damage in our patients.
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Abu Shakra M, Urowitz MB, Gladman DD, Gough J (1995) Mortality studies in systemic lupus erythematosus. Results from a single center. I. Causes of death. J Rheumatol 22:1259–1264
Urowitz MB, Abu Shakra M, Gladman DD, Gough J, Farewell VT (1997) Improved survival in SLE. J Rheumatol 24:1051–1065
Merrell M, Shulman LE (1955) Determination of prognosis in chronic disease, illustrated by systemic lupus erythematosus. J Chronic Dis 1:12–32
Gladman D, Ginzler E, Goldsmith C et al (1996) The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index for systemic lupus erythematosus. Arthritis Rheum 39:363–369
Rahman P, Gladman DD, Urowitz MB, Hallett D, Tam LS (2001) Early damage as measured by the SLICC/ACR damage index is a predictor of mortality in systemic lupus erythematosus. Lupus 10:93–96
Rivest C, Lew RA, Welsing PM et al (2000) Association between clinical factors, socioeconomic status and organ damage in recent onset systemic lupus erythematosus. J Rheumatol 27:680–684
Tan E, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF et al (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25:1271–1277
Vilar MJP, Sato EI (2002) Estimating the incidence of systemic lupus erythematosus in a tropical region (Natal-Brazil). Lupus 11:528–532
Zonana Nacach A, Camargo-Coronel A, Yanez P et al (1998) Measurement of damage in 210 Mexican patients with systemic lupus erythematosus: relationship with disease duration. Lupus 7:119–123
Mok CC, Ho CT, Wong RW, Lau CS (2003) Damage accrual in southern Chinese patients with systemic lupus erythematosus. J Rheumatol 30:1513–1519
Zonana Nacach A, Barr SG, Magder LS, Petri M (2000) Damage in systemic lupus erythematosus and its association with corticosteroids. Arthritis Rheum 43:1801–1808
Alarcon GS, Roseman JM, McGwin G Jr, Uribe A, Bastian HM, Fessler BJ, Baethge BA, Friedman AW, Reveille JD, LUMINA Study Group (2004) Systemic lupus erythematosus in three ethnic groups XX. Damage as a predictor of further damage. Rheumatology (Oxford) 43:202–205
Nived O, Jonsen A, Bengtsson C, Sturfelt G (2002) High predictive value of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index for survival in systemic lupus erythematosus. J Rheumatol 29:1398–1400
Karlson EW, Daltroy LH, Lew RA et al (1997) The relationship of socioeconomic status, race, and modifiable risk factors to outcomes in patients with systemic lupus erythematosus. Arthritis Rheum 40:47–56
Acknowledgments
The authors gratefully acknowledge the support of the Brazilian Society of Rheumatology (Pronuclear Project), especially Dr. Luis Eduardo Coelho Andrade and Dr. Rozana Mesquita Ciconelli.
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Vilar, M.J.P., Bezerra, E.L.M. & Sato, E.I. Skin is the most frequently damaged system in recent-onset systemic lupus erythematosus in a tropical region. Clin Rheumatol 24, 377–380 (2005). https://doi.org/10.1007/s10067-004-1041-1
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DOI: https://doi.org/10.1007/s10067-004-1041-1