Abstract
The authors studied eight cases of Churg-Strauss syndrome (CSS) associated with the use of pranlukast, a common cysteinyl leukotriene receptor antagonist (LTRA) in Japan. The patients who received pranlukast showed significantly increased peripheral blood eosinophil count, neurological disability scores, and poor responses to corticosteroid in comparison with those patients not receiving pranlukast. We suggest that preceding administration of pranlukast aggravates clinical presentations of CSS.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- BVAS :
-
Birmingham Vasculitis Activity Score
- CSS :
-
Churg-Strauss syndrome
- LTRA :
-
Cysteinyl leukotriene receptor antagonist
- FFS :
-
Five-factor score
References
Franco J, Artes MJ (1999) Pulmonary eosinophilia associated with montelukast. Thorax 54:558–560
Kinoshita M, Shiraishi T, Koga T et al (1999) Churg-Strauss syndrome after corticosteroid withdrawal in an asthmatic patient treated with pranlukast. J Allergy Clin Immunol 103:534–535
Wechsler ME, Garpestad E, Flier SR et al (1998) Pulmonary infiltrates, eosinophilia, and cardiomyopathy following corticosteroid withdrawal in patients with asthma receiving zafirlukast. JAMA 279:455–457
Wechsler ME, Finn D, Gunawardena D et al (2000) Churg-Strauss syndrome in patients receiving montelukast as treatment for asthma. Chest 117:708–713
Green RL, Vayonis AG (1999) Churg-Strauss syndrome after zafirlukast in two patients not receiving systemic steroid treatment. Lancet 353:725–726
Baba K, Niwa S, Yagi T et al (2000) Churg-Strauss syndrome during corticosteroid tapering in a patient with bronchial asthma receiving pranlukast. Arerugi 49:512–515
Hayashi S, Furuya S, Imamura H (2001) Fulminant eosinophilic endomyocarditis in an asthmatic patient treated with pranlukast after corticosteroid withdrawal. Heart 86:E7
Hashimoto M, Fujishima T, Tanaka H et al (2001) Churg-Strauss syndrome after reduction of inhaled corticosteroid in a patient treated with pranlukast for asthma. Intern Med 40:432–434
Shigeto K, Shyugo I, Naoto T et al (2003) Churg-Strauss syndrome (CSS) in a patient receiving pranlukast. Clin Rheumatol 22:491–492
Masi AT, Hunder GG, Lie JT et al (1990) The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis). Arthritis Rheum 33:1094–1100
Luqmani RA, Bacon PA, Moots RJ et al (1994) Birmingham Vasculitis Activity Score (BVAS) in systemic necrotizing vasculitis. QJM 87:671–678
Guillevin L, Lhote F, Gayraud M et al (1996) Prognostic factors in polyarteritis nodosa and Churg-Strauss syndrome: a prospective study in 342 patients. Medicine (Baltimore) 75:17–28
van Swieten JC, Koudstaal PJ, Visser MC et al (1988) Interobserver agreement for the assessment of handicap in stroke patients. Stroke 19:604–607
Drazen JM, Israel E, O’Byrne PM (1999) Treatment of asthma with drugs modifying the leukotriene pathway. N Engl J Med 340:197–206
Lewis RA, Austen KF, Soberman RJ et al (1990) Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases. N Engl J Med 323:645–655
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Shimbo, J., Onodera, O., Tanaka, K. et al. Churg-Strauss syndrome and the leukotriene receptor antagonist pranlukast. Clin Rheumatol 24, 661–662 (2005). https://doi.org/10.1007/s10067-004-1035-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10067-004-1035-z