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Trace elements and some extracellular antioxidant proteins levels in serum of patients with systemic lupus erythematosus

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Abstract

Systemic lupus erythematosus (SLE) is a chronic progressive autoimmune disorder with a wide spectrum of clinical and immunological abnormalities. In this study, we aimed to investigate the levels of serum zinc (Zn), copper (Cu), magnesium (Mg), manganese (Mn), iron (Fe), ceruloplasmin (Cp), transferrin (Trf), and albumin (Alb) in SLE and whether it is related to the severity of the clinical condition of this chronic disease. Cp and Cu levels were higher, while Trf, Alb, Zn, Mg, Mn, and Fe levels were lower in serum of patients with SLE (n=27) compared with healthy controls (n=20). The mechanisms by which these alterations occur in certain inflammatory conditions need to be elucidated. It is also obscure whether these alterations are a cause or a consequence of the inflammation. As a conclusion, alterations in the levels of the parameters in SLE may not be a reason for, but in fact a consequence of the disease itself.

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Abbreviations

CNS:

Central nervous system

Cp:

Ceruloplasmin

CRP:

C-reactive protein

Cu:

Copper

ESR:

Erythrocyte sedimentation rate

Fe:

Iron

Mg:

Magnesium

Mn:

Manganese

SLE:

Systemic lupus erythematosus

SLEDAI:

SLE Disease Activity Index

Trf:

Transferrin

Zn:

Zinc

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Authors and Affiliations

  1. Department of Biochemistry, Nenehatun Obstetrics and Gynecology Hospital, Ataturk University, Cat yolu, 25240, Erzurum, Turkey

    Adnan Yilmaz

  2. Immunology, School of Medicine, Ataturk University, 25240, Erzurum, Turkey

    Refik Ali Sari

  3. Internal Medicine, School of Medicine, Ataturk University, 25240, Erzurum, Turkey

    Mehmet Gundogdu & Erdinc Dag

  4. Department of Cardiology, School of Medicine, Ataturk University, 25240, Erzurum, Turkey

    Nuri Kose

Authors
  1. Adnan Yilmaz
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  2. Refik Ali Sari
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  3. Mehmet Gundogdu
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  4. Nuri Kose
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  5. Erdinc Dag
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Correspondence to Adnan Yilmaz.

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Yilmaz, A., Sari, R.A., Gundogdu, M. et al. Trace elements and some extracellular antioxidant proteins levels in serum of patients with systemic lupus erythematosus. Clin Rheumatol 24, 331–335 (2005). https://doi.org/10.1007/s10067-004-1028-y

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  • DOI: https://doi.org/10.1007/s10067-004-1028-y

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