Abstract
Familial Mediterranean fever (FMF) is prevalent among Arabic, Turkish, Armenian, and Jewish people and it must always be considered in the differential diagnosis of patients from these ethnic groups presenting with recurrent abdominal pain with fever. In cases of fever and recurrent abdominal pain, acute pancreatitis is an important clinical condition, which should be considered in the differential diagnosis. Serum amylase concentration in acute pancreatitis is usually more than three times the upper limit of normal. However, in recurrent pancreatitis secondary to hypertriglyceridemia, serum amylase levels, for reasons that are not well understood, may be normal or mildly elevated. Recurrent pancreatitis secondary to hypertriglyceridemia may thus pose a problem in the differential diagnosis and may lead to an erroneous diagnosis of FMF. Measurement of serum triglyceride along with amylase levels should be required for a suspected diagnosis. Computerized examination of the abdomen may need to be undertaken to exclude acute pancreatitis in the presence of hypertriglyceridemia since serum amylase levels may be normal or slightly elevated.
References
Ben-Chetrit E, Levy M (1998) Familial Mediterranean fever. Lancet 351:659–664
Drenth JP, Haagsma CJ, van der Meer JW (1994) Hyperimmunoglobulinemia D and periodic fever syndrome. The clinical spectrum in a series of 50 patients. International Hyper-IgD Study Group. Medicine (Baltimore) 73:133–144
McDermott EM, Smillie DM, Powell RJ (1997) Clinical spectrum of familial Hibernian fever: a 14-year follow-up study of the index case and extended family. Mayo Clin Proc 72:806–817
Drenth JP, van der Meer JW (2001) Hereditary periodic fever. N Engl J Med 345:1748–1757
Shohat M, Livneh A, Zemer D, Pras M, Sohar E (1992) Twin studies in familial Mediterranean fever. Am J Med Genet 44:179–182
Peters RS (1997) Non-response to daily colchicine attack suppression in familial Mediterranean fever (FMF). The First International Conference on Familial Mediterranean Fever (FMF), 7–11 September 1997, Jerusalem, Israel
Toskes PP (1990) Hyperlipidemic pancreatitis. Gastroenterol Clin North Am 19:783–791
Sharma P, Lim S, James D, Orchard RT, Horne M, Seymour CA (1996) Pancreatitis may occur with a normal amylase concentration in hypertriglyceridaemia. BMJ 313:1265
Okerberg K, Lee M (1999) Spuriously normal amylase levels in a patient with acute pancreatitis secondary to hypertriglyceridemia. J Am Board Fam Pract 12:68–70
Fortson MR, Freedman SN, Webster PD, 3rd (1995) Clinical assessment of hyperlipidemic pancreatitis. Am J Gastroenterol 90:2134–2139
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Birlik, M., Demir, T., Zeybel, M. et al. A case of recurrent pancreatitis due to hyperlipidemia misdiagnosed as familial Mediterranean fever. Clin Rheumatol 23, 559–561 (2004). https://doi.org/10.1007/s10067-004-0922-7
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DOI: https://doi.org/10.1007/s10067-004-0922-7