Depigmentation – a rare side effect to intra-articular glucocorticoid treatment


Intra-articular glucocorticoid injections are often used in patients with rheumatoid arthritis, either as bridging therapy or in periods with increased disease activity. We present a case of local skin depigmentation that occurred at the site of injection in a dark-skinned patient. Depigmentation is a rare complication of such therapy but may have important implications for dark-skinned patients.

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Fig. 1



Disease-modifying anti-rheumatic drugs


Rheumatoid arthritis


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Correspondence to Merete Lund Hetland.

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Rogojan, C., Hetland, M.L. Depigmentation – a rare side effect to intra-articular glucocorticoid treatment. Clin Rheumatol 23, 373–375 (2004).

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  • Depigmentation
  • Intra-articular corticosteroid injections
  • Rheumatoid arthritis
  • Side effect