Recently, graphene oxide (GO), one of the carbon nanomaterials, has received much attention due to its unique physical and chemical properties and high potential in many research areas, including applications as a biosensor and drug delivery vehicle. Various GO-based biosensors have been developed, largely based on its surface adsorption properties for detecting biomolecules, such as nucleotides and peptides, and real-time monitoring of enzymatic reactions. In this review, we discuss recent advances in GO-based biosensors focusing on a novel assay platform for helicase activity, which was also employed in high-throughput screening to discover selective helicase inhibitors.
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Jang, H., Ryoo, SR., Lee, M.J. et al. A new helicase assay based on graphene oxide for anti-viral drug development. Mol Cells 35, 269–273 (2013). https://doi.org/10.1007/s10059-013-0066-1
- drug screening
- graphene oxide
- hepatitis C