In this study, we investigated the cytoprotective effects of Inonotus obliquus against oxidative stress-induced apoptosis and premature senescence. Pretreatment with I. obliquus scavenged intracellular ROS and prevented lipid peroxidation in hydrogen peroxide-treated human fibroblasts. As a result, I. obliquus exerted protective effects against hydrogen peroxide-induced apoptosis and premature senescence in human fibroblasts. In addition, I. obliquus suppressed UV-induced morphologic skin changes, such as skin thickening and wrinkle formation, in hairless mice in vivo and increased collagen synthesis through inhibition of MMP-1 and MMP-9 activities in hydrogen peroxide-treated human fibroblasts. Taken together, these results demonstrate that I. obliquus can prevent the aging process by attenuating oxidative stress in a model of stress-induced premature senescence.
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Yun, J.S., Pahk, J.W., Lee, J.S. et al. Inonotus obliquus protects against oxidative stress-induced apoptosis and premature senescence. Mol Cells 31, 423–429 (2011). https://doi.org/10.1007/s10059-011-0256-7
- Inonotus obliquus
- reactive oxygen species (ROS) stress-induced premature senescence