Abstract
The aim of this study was to investigate the preventive effect of Agrocybe chaxingu polysaccharide on streptozocin (STZ)-induced pancreatic β-cells destruction. Agrocybe chaxingu polysaccharide markedly reduced nitric oxide (NO) production and iNOS expression levels in RINm5F cells in a dose-dependent manner. In addition, Agrocybe chaxingu polysaccharide significantly inhibited iNOS expression and blood glucose levels in STZ-induced diabetic mice. Moreover, immunohistochemical analysis revealed that it enhanced pancreatic β-cells resistance to destruction by STZ. These results suggest that Agrocybe chaxingu polysaccharide may have value as a therapeutic agent against diabetes mellitus.
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An erratum to this article is available at http://dx.doi.org/10.1007/s10059-013-1044-3.
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Lee, B.R., Lee, Y.P., Kim, D.W. et al. Amelioration of streptozotocin-induced diabetes by Agrocybe chaxingu polysaccharide. Mol Cells 29, 349–354 (2010). https://doi.org/10.1007/s10059-010-0044-9
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DOI: https://doi.org/10.1007/s10059-010-0044-9