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Protein folding simulations in a deformed energy landscape

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A modified version of stochastic tunneling, a recently introduced global optimization technique, is introduced as a new generalized-ensemble technique and tested for a benchmark peptide, Met-enkephalin. It is demonstrated that the new technique allows to evaluate folding properties and especially the glass temperature of this peptide.

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Received 2 September 1999

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Hansmann, U. Protein folding simulations in a deformed energy landscape. Eur. Phys. J. B 12, 607–611 (1999). https://doi.org/10.1007/s100510051044

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  • DOI: https://doi.org/10.1007/s100510051044

  • PACS. 05.10.-a Computational methods in statistical physics and nonlinear dynamics – 87.16.Ac Theory and modeling; computer simulation