Zusammenfassung
Die Mortalität beim präklinischen Herz-Kreislauf-Stillstand ist nach wie vor sehr hoch. Seine Ursachen können vielfältig sein. Am häufigsten ist zwar immer noch der Myokardinfarkt, dieser ist aber in den letzten Jahren als Ursache deutlich zurückgegangen. Für den Myokardinfarkt ist die sofortige Intervention der Goldstandard, bei extrakardialen Ursachen kann der Umweg über eine Intervention ohne weitere andere Diagnostik aber verhängnisvoll sein. Es ist deshalb Gegenstand der Diskussion, ob die sofortige Verbringung des Patienten in das Herzkatheterlabor und gegebenenfalls die Intervention und Anlage eines „extracorporeal life support“ (ECLS) sinnvoll ist oder ob bei Ankunft des Patienten ein interdisziplinäres konservatives Schockraumteam aus Kardiologen, Notfall- oder Intensivmedizinern in einem Kurzcheck die weitere Diagnostik und Therapie des Patienten festlegen und gegebenenfalls weitere Fachexperten hinzuziehen soll. Der Beitrag soll das Pro und Kontra der beiden Vorgehensweisen beleuchten.
Abstract
Mortality following out-of-hospital cardiac arrest (OHCA) remains high and may have various causes. Although myocardial infarction is still the most frequent cause of cardiac arrest, it has declined significantly in recent years. Immediate intervention is the gold standard in patients with acute myocardial infarction. However, in patients with non-cardiac causes of OHCA, a detour via the cardiac catheter laboratory, thereby delaying further diagnosis, can be fatal. The optimal strategic algorithm in this clinical scenario is unclear. Thus it is the subject of discussion whether immediate transfer of the patient to the catheter laboratory or an initial diagnostic and therapeutic work-up by the interdisciplinary conservative shock room team of cardiologists, emergency or intensive care physicians is the best strategy in patients following OHCA. Therefore, this review focuses on existing data and recommendations and tries to present a strategic algorithm.
Literatur
Anyfantakis ZA, Baron G, Aubry P et al (2009) Acute coronary angiographic findings in survivors of out-of-hospital cardiac arrest. Am Heart J 157:312–318. https://doi.org/10.1016/j.ahj.2008.09.016
AWMF (2017) S3-Leitlinie Polytrauma/Schwerverletzten-Behandlung. https://www.awmf.org/uploads/tx_szleitlinien/012-019k_S3_Polytrauma_Schwerverletzten-Behandlung_2017-03.pdf. Zugegriffen: 08.11.2018
Belohlavek J (2012) NCT01511666. Hyperinvasive Approach in Cardiac Arrest. https://clinicaltrials.gov/ct2/show/NCT01511666. Zugegriffen: 08.11.2018
Belohlavek J, Smid O, Franek O et al (2016) Hyperinvasive approach prolongs the time window for favorable outcomes in refractory out-of-hospital cardiac arrest: a preliminary analysis of the “Prague OHCA Study”. Resuscitation 106:e18. https://doi.org/10.1016/j.resuscitation.2016.07.041
Bernhard M, Hartwig T, Ramshorn-Zimmer A et al (2014) Schockraummanagement kritisch kranker Patienten in der Zentralen Notaufnahme. Intensiv Notfallbehandl 39:93–108. https://doi.org/10.5414/IBX00425
Bernhard M, Ramshorn-Zimmer A, Hartwig T et al (2014) Schockraummanagement kritisch erkrankter Patienten. Anders als beim Trauma? Anaesthesist 63(2):144–153. https://doi.org/10.1007/s00101-013-2258-7
Bernhard M, Trautwein S, Stepan R et al (2014) Notärztliche Einschätzung der klinischen Weiterversorgung von Notfallpatienten. Anaesthesist 63:394–400. https://doi.org/10.1007/s00101-014-2313-z
Bernhard M, Döll S, Hartwig T et al (2018) Resuscitation room management of critically ill nontraumatic patients in a German emergency department (OBSERvE-study). Eur J Emerg Med. https://doi.org/10.1097/MEJ.0000000000000543
Böttiger BW, Bernhard M, Knapp J et al (2016) Influence of EMS-physician presence on survival after out-of-hospital cardiopulmonary resuscitation: systematic review and meta-analysis. Crit Care 20:4. https://doi.org/10.1186/s13054-015-1156-6
Braun M, Schmidt WU, Möckel M et al (2016) Coma of unknown origin in the emergency department: implementation of an in-house management routine. Scand J Trauma Resusc Emerg Med 24:61. https://doi.org/10.1186/s13049-016-0250-3
Callaway CW, Schmicker RH, Brown SP et al (2014) Early coronary angiography and induced hypothermia are associated with survival and functional recovery after out-of-hospital cardiac arrest. Resuscitation 85:657–663. https://doi.org/10.1016/j.resuscitation.2013.12.028
Cobb LA, Fahrenbruch CE, Olsufka M et al (2002) Changing incidence of out-of-hospital ventricular fibrillation, 1980-2000. JAMA 288:3008–3013
Desch S (2016) NCT02750462. Immediate Unselected Coronary Angiography Versus Delayed Triage in Survivors of Out-of-hospital Cardiac Arrest Without ST-segment Elevation (TOMAHAWK). https://www.clinicaltrials.gov/ct2/show/NCT02750462. Zugegriffen: 08.11.2018
DGU Weißbuch Schwerverletztenversorgung (2012) http://www.dgu-online.de/uploads/media/DGU_Weissbuch_A4_Internetendgueltige_version_1_.pdf. Zugegriffen: 08.11.2018
Dumas F, Bougouin W, Geri G et al (2016) Emergency percutaneous coronary intervention in post-cardiac arrest patients without ST-segment elevation pattern: insights from the PROCAT II registry. JACC Cardiovasc Interv 9:1011–1018. https://doi.org/10.1016/j.jcin.2016.02.001
Elfwén L, Lagedal R, James S et al (2018) Coronary angiography in out-of-hospital cardiac arrest without ST elevation on ECG-Short- and long-term survival. Am Heart J 200:90–95. https://doi.org/10.1016/j.ahj.2018.03.009
Fischer M, Kehrberger E, Marung H et al (2016) Eckpunktepapier 2016 zur notfallmedizinischen Versorgung der Bevölkerung in der Prähospitalphase und in der Klinik. Notf Rettungsmed 19:387–395. https://doi.org/10.1007/s10049-016-0187-0
Gräsner JT, Lefering R, Koster RW et al (2016) EuReCa ONE-27 Nations, ONE Europe, ONE Registry: A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe. Resuscitation 105:188–195
Herlitz J, Engdahl J, Svensson L et al (2005) Changes in demographic factors and mortality after out-of-hospital cardiac arrest in Sweden. Coron Artery Dis 16:51–57
Hosmane VR, Mustafa NG, Reddy VK et al (2009) Survival and neurologic recovery in patients with ST-segment elevation myocardial infarction resuscitated from cardiac arrest. J Am Coll Cardiol 53:409–415. https://doi.org/10.1016/j.jacc.2008.08.076
Ibanez B, James S, Agewall S et al (2018) 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 39:119–177. https://doi.org/10.1093/eurheartj/ehx393
Larsen JM, Ravkilde J (2012) Acute coronary angiography in patients resuscitated from out-of-hospital cardiac arrest—a systematic review and meta-analysis. Resuscitation 83:1427–1433. https://doi.org/10.1016/j.resuscitation.2012.08.337
Liu VX, Fielding-Singh V, Greene JD, Baker JM et al (2017) The timing of early antibiotics and hospital mortality in sepsis. Am J Respir Crit Care Med 196:856–863. https://doi.org/10.1164/rccm.201609-1848OC
Millin MG, Comer AC, Nable J et al (2016) Patients without ST elevation after return of spontaneous circulation may benefit from emergent percutaneous intervention: a systematic review and meta-analysis. Resuscitation 108:54–60. https://doi.org/10.1016/j.resuscitation.2016.09.004
Nichol G, Thomas E, Callaway CW et al (2008) Regional variation in out-of-hospital cardiac arrest incidence and outcome. JAMA 300:1423–1431
Noc M, Fajadet J, Lassen JF et al (2014) Invasive coronary treatment strategies for out-of-hospital cardiac arrest: a consensus statement from the European association for percutaneous cardiovascular interventions (EAPCI)/stent for life (SFL) groups. Eurointervention 10:31–37. https://doi.org/10.4244/EIJV10I1A7
Rab T, Kern KB, Tamis-Holland JE et al (2015) Cardiac arrest: a treatment algorithm for emergent invasive cardiac procedures in the resuscitated comatose patient. J Am Coll Cardiol 66(1):62–73. https://doi.org/10.1016/j.jacc.2015.05.009
Radsel P, Knafelj R, Kocjancic S et al (2011) Angiographic characteristics of coronary disease and postresuscitation electrocardiograms in patients with aborted cardiac arrest outside a hospital. Am J Cardiol 108:634–638. https://doi.org/10.1016/j.amjcard.2011.04.008
Reynolds JC, Frisch A, Rittenberger JC et al (2013) Duration of resuscitation efforts and functional outcome after out-of-hospital cardiac arrest: when should we change to novel therapies? Circulation 128:2488–2494. https://doi.org/10.1161/CIRCULATIONAHA.113.002408
Riessen R, Busch HJ, Haap M (2017) Invasive Koronardiagnostik im Rahmen einer Postreanimationsbehandlung nach außerklinischem Herzstillstand. Aktuel Kardiol 6:53–58. https://doi.org/10.1055/s-0042-123186
Roffi M, Patrona C, Collet JP et al (2016) 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J 37:267–315. https://doi.org/10.1093/eurheartj/ehv320
Rubertsson S (2014) NCT02309151. Direct or Subacute Coronary Angiography for Out-of-hospital Cardiac Arrest (DISCO). https://clinicaltrials.gov/ct2/show/NCT02309151. Zugegriffen: 08.11.2018
Salam I, Hassager C, Thomsen JH et al (2016) Editor’s Choice-Is the pre-hospital ECG after out-of-hospital cardiac arrest accurate for the diagnosis of ST-elevation myocardial infarction? Eur Heart J Acute Cardiovasc Care 5:317–326. https://doi.org/10.1177/2048872615585519
Scholz KH, Andresen D, Böttiger BW et al (2017) Qualitätsindikatoren und strukturelle Voraussetzungen für Cardiac-Arrest-Zentren – Deutscher Rat für Wiederbelebung/German Resuscitation Council (GRC). Notfall Rettungsmed 20:234–236. https://doi.org/10.1007/s10049-017-0288-4
Spaulding CM, Joly LM, Rosenberg A et al (1997) Immediate coronary angiography in survivors of out-of-hospital cardiac arrest. N Engl J Med 336:1629–1633. https://doi.org/10.1056/NEJM199706053362302
Thiele H, Akin I, Sandri M et al (2017) PCI strategies in patients with acute myocardial infarction and cardiogenic shock. N Engl J Med 377:2419–2432. https://doi.org/10.1056/NEJMoa1710261
Tranberg T, Lippert FK, Christensen EF et al (2017) Distance to invasive heart centre, performance of acute coronary angiography, and angioplasty and associated outcome in out-of-hospital cardiac arrest: a nationwide study. Eur Heart J 38:1645–1652. https://doi.org/10.1093/eurheartj/ehx104
Väyrynen T, Boyd J, Sorsa M et al (2011) Long-term changes in the incidence of out-of-hospital ventricular fibrillation. Resuscitation 82:825–829. https://doi.org/10.1016/j.resuscitation.2011.02.030
Zanuttini D, Armellini I, Nucifora G et al (2013) Predictive value of electrocardiogram in diagnosing acute coronary artery lesions among patients with out-of-hospital-cardiac-arrest. Resuscitation 84:1250–1254. https://doi.org/10.1016/j.resuscitation.2013.04.023
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Interessenkonflikt
B. Kumle und M. Orban geben an, dass kein Interessenkonflikt besteht.
Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.
Additional information
Redaktion
M. Bernhard, Düsseldorf
H. Dormann, Fürth
C. Waydhas, Bochum
M. Orban und B. Kumle teilen sich die Erstautorenschaft. M. Orban hat den Pro-Teil dieses Beitrags verfasst. B. Kumle schrieb den Kontra-Teil.
Rights and permissions
About this article
Cite this article
Kumle, B., Orban, M. Vorgehen nach präklinischem Herz-Kreislauf-Stillstand. Notfall Rettungsmed 22, 696–703 (2019). https://doi.org/10.1007/s10049-018-0547-z
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10049-018-0547-z
Schlüsselwörter
- ST-Hebungs-Myokardinfarkt
- Reanimation
- Perkutane Koronarintervention
- Konservatives Schockraummanagement
- Extrakorporale Kreislaufunterstützung