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Empfehlungen der Europäischen Gesellschaft für Kardiologie-Leitlinien 2017 – STEMI

Recommendations of the European Society of Cardiology Guideline 2017—STEMI

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Zusammenfassung

In diesem Beitrag werden die aktuellen Leitlinien der Europäischen Gesellschaft für Kardiologie aus dem Jahr 2017 zur Diagnostik und Therapie des akuten ST-Strecken-Hebungsinfarkts (STEMI) dargelegt und v. a. die Änderungen im Vergleich zu den früheren STEMI-Leitlinien von 2012 herausgearbeitet. Die primäre perkutane Koronarintervention (PCI) bleibt die bevorzugte Reperfusionstherapie. Veränderungen hinsichtlich der Revaskularisation betreffen besonders Empfehlungen zur Wahl des radialen Zugangswegs, zur Verwendung von Drug-Eluting-Stents anstelle von Bare-Metal-Stents sowie zur kompletten Revaskularisation und Vermeidung der Thrombusaspiration. Bei der Begleittherapie während der PCI wurde Bivalirudin herabgestuft. Die Indikation für eine O2-Therapie ist nur noch bei einer O2-Sättigung von <90 % gegeben. Die intraaortale Ballonpumpe sollte im kardiogenen Schock nicht mehr verwendet werden. Neue Empfehlungen gibt es auch in Bezug auf die Dauer der dualen Antiplättchentherapie für Patienten, bei denen nach den initialen 12 Monaten kein Blutungsereignis aufgetreten ist. Neue überarbeitete Abschnitte betreffen den Myokardinfarkt ohne relevante Koronarstenosen, die Einführung von Qualitätsindikatoren für Herzinfarktnetzwerke und neue Definitionen für die Zeiten bis zur Reperfusion.

Abstract

This article gives an update on the management of ST-segment elevation myocardial infarction (STEMI) according to the recently released 2017 European Society of Cardiology guidelines. Primary percutaneous coronary intervention remains the preferred reperfusion strategy. New guideline recommendations relate to the access site with clear preference of the radial artery, use of drug-eluting stents over bare-metal stents, complete revascularization during the index hospitalization, and avoidance of routine thrombus aspiration. For periprocedural anticoagulation, bivalirudin has been downgraded. Oxygen should be administered only if oxygen saturation is <90%. In cardiogenic shock, intra-aortic balloon pumping should not be used anymore. New recommendations are in place with respect to dual antiplatelet therapy duration for patients without a bleeding event during the first 12 months. Newly introduced chapters cover myocardial infarction with nonobstructed coronary arteries (MINOCA), new indicators for quality of care for STEMI networks, and new definitions for time to reperfusion.

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Literatur

  1. Thygesen K, Alpert JS, Jaffe AS et al (2012) Third universal definition of myocardial infarction. Eur Heart J 33:2551–2567

    Article  PubMed  Google Scholar 

  2. Mcmanus DD, Gore J, Yarzebski J et al (2011) Recent trends in the incidence, treatment, and outcomes of patients with STEMI and NSTEMI. Am J Med 124:40–47

    Article  PubMed  PubMed Central  Google Scholar 

  3. Jernberg T (2016) Swedeheart annual report 2015. In. Karolinska university hospital, Huddinge, 2228 14186 Stockholm

    Google Scholar 

  4. Kristensen SD, Laut KG, Fajadet J et al (2014) Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011: current status in 37 ESC countries. Eur Heart J 35:1957–1970

    Article  PubMed  Google Scholar 

  5. Puymirat E, Simon T, Steg PG et al (2012) Association of changes in clinical characteristics and management with improvement in survival among patients with st-elevation myocardial infarction. JAMA 308:998–1006

  6. Gale CP, Allan V, Cattle BA et al (2014) Trends in hospital treatments, including revascularisation, following acute myocardial infarction, 2003–2010: a multilevel and relative survival analysis for the National Institute for Cardiovascular Outcomes Research (NICOR). Heart 100:582–589

    Article  CAS  PubMed  Google Scholar 

  7. Ibanez B, James S, Agewall S et al (2017) 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J ehx1393. https://doi.org/10.1093/eurheartj/ehx393

    PubMed  Google Scholar 

  8. Stub D, Smith K, Bernard S et al (2015) Air versus oxygen in ST-segment-elevation myocardial infarction. Circulation 131:2143–2150

    Article  CAS  PubMed  Google Scholar 

  9. Hofmann R, James SK, Svensson L et al (2014) DETermination of the role of OXygen in suspected acute myocardial infarction trial. Am Heart J 167:322–328

    Article  CAS  PubMed  Google Scholar 

  10. Hofmann R, James SK, Jernberg T et al (2017) Oxygen therapy in suspected acute myocardial infarction. N Engl J Med 377:1240–1249

    Article  CAS  PubMed  Google Scholar 

  11. Kubica J, Adamski P, Ostrowska M et al (2016) Morphine delays and attenuates ticagrelor exposure and action in patients with myocardial infarction: the randomized, double-blind, placebo-controlled IMPRESSION trial. Eur Heart J 37:245–252

    Article  PubMed  Google Scholar 

  12. Kubica J, Kubica A, Jilma B et al (2016) Impact of morphine on antiplatelet effects of oral P2Y12 receptor inhibitors. Int J Cardiol 215:201–208

    Article  PubMed  Google Scholar 

  13. Jolly SS, Yusuf S, Cairns J et al (2011) Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial. Lancet 377:1409–1420

    Article  PubMed  Google Scholar 

  14. Mamas MA, Anderson SG, Carr M et al (2014) Baseline bleeding risk and arterial access site practice in relation to procedural outcomes after percutaneous coronary intervention. J Am Coll Cardiol 64:1554–1564

    Article  PubMed  Google Scholar 

  15. Romagnoli E, Biondi-Zoccai G, Sciahbasi A et al (2012) Radial versus femoral randomized investigation in ST-segment elevation acute coronary syndrome: the RIFLE-STEACS (Radial Versus Femoral Randomized Investigation in ST-Elevation Acute Coronary Syndrome) study. J Am Coll Cardiol 60:2481–2489

    Article  PubMed  Google Scholar 

  16. Valgimigli M, Gagnor A, Calabro P et al (2015) Radial versus femoral access in patients with acute coronary syndromes undergoing invasive management: a randomised multicentre trial. Lancet 385:2465–2476

    Article  PubMed  Google Scholar 

  17. Roffi M, Patrono C, Collet J‑P et al (2016) 2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Task force for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation of the European society of Cardiology (ESC). Eur Heart J 37:267–315

    Article  PubMed  Google Scholar 

  18. Sabate M, Cequier A, Iniguez A et al (2012) Everolimus-eluting stent versus bare-metal stent in ST-segment elevation myocardial infarction (EXAMINATION): 1 year results of a randomised controlled trial. Lancet 380:1482–1490

    Article  CAS  PubMed  Google Scholar 

  19. Sabate M, Brugaletta S, Cequier A et al (2016) Clinical outcomes in patients with ST-segment elevation myocardial infarction treated with everolimus-eluting stents versus bare-metal stents (EXAMINATION): 5‑year results of a randomised trial. Lancet 387:357–366

    Article  PubMed  Google Scholar 

  20. Raber L, Kelbaek H, Ostojic M et al (2012) Effect of biolimus-eluting stents with biodegradable polymer vs bare-metal stents on cardiovascular events among patients with acute myocardial infarction: the COMFORTABLE AMI randomized trial. JAMA 308:777–787

    Article  CAS  PubMed  Google Scholar 

  21. Bonaa KH, Mannsverk J, Wiseth R et al (2016) Drug-eluting or bare-metal stents for coronary artery disease. N Engl J Med 375:1242–1252

    Article  CAS  PubMed  Google Scholar 

  22. Jolly SS, Cairns JA, Yusuf S et al (2015) Randomized trial of primary PCI with or without routine manual thrombectomy. N Engl J Med 372:1389–1398

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Fröbert O, Lagerqvist B, Olivecrona GK et al (2013) Thrombus aspiration during ST-segment elevation myocardial infarction. N Engl J Med 369:1587–1597

    Article  PubMed  Google Scholar 

  24. Thiele H, Desch S, Piek JJ et al (2016) Multivessel versus culprit lesion only percutaneous revascularization plus potential staged revascularization in patients with acute myocardial infarction complicated by cardiogenic shock: design and rationale of CULPRIT-SHOCK trial. Am Heart J 172:160–169

    Article  PubMed  Google Scholar 

  25. Smits PC, Abdel-Wahab M, Neumann F‑J et al (2017) Fractional flow reserve-guided multivessel angioplasty in myocardial infarction. N Engl J Med 376:1234–1244

    Article  PubMed  Google Scholar 

  26. Gershlick AH, Khan JN, Kelly DJ et al (2015) Randomized trial of complete versus lesion-only revascularization in patients undergoing primary percutaneous coronary intervention for STEMI and multivessel disease: the CvLPRIT trial. J Am Coll Cardiol 65:963–972

    Article  PubMed  PubMed Central  Google Scholar 

  27. Wald DS, Morris JK, Wald NJ et al (2013) Randomized trial of preventive angioplasty in myocardial infarction. N Engl J Med 369:1115–1123

    Article  CAS  PubMed  Google Scholar 

  28. Engstrom T, Kelbaek H, Helqvist S et al (2015) Complete revascularisation versus treatment of the culprit lesion only in patients with ST-segment elevation myocardial infarction and multivessel disease (DANAMI-3-PRIMULTI): an open-label, randomised controlled trial. Lancet 386:665–671

    Article  PubMed  Google Scholar 

  29. De Waha S, Jobs A, Pöss J et al (2017) Multivessel versus culprit lesion only percutaneous coronary intervention in cardiogenic shock complicating acute myocardial infarction: a systematic review and meta-analysis. Eur Heart J Acute Cardiovasc Care. https://doi.org/10.1177/2048872617719640

    Google Scholar 

  30. Thiele H, Akin I, Sandri M et al (2017) PCI strategies in patients with acute myocardial infarctionand cardiogenic shock. N Engl J Med. https://doi.org/10.1056/NEJMoa1710261

    Google Scholar 

  31. Thiele H, Zeymer U, Neumann F‑J et al (2013) Intraaortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock. Final 12-month results of the randomised IntraAortic Balloon Pump in cardiogenic Shock II (IABP-SHOCK II) trial. Lancet 382:1638–1645

    Article  PubMed  Google Scholar 

  32. Thiele H, Zeymer U, Neumann F‑J et al (2012) Intraaortic balloon support for myocardial infarction with cardiogenic shock. N Engl J Med 367:1287–1296

    Article  CAS  PubMed  Google Scholar 

  33. Zeymer U, Hohlfeld T, Vom Dahl J et al (2017) Prospective, randomised trial of the time dependent antiplatelet effects of 500 mg and 250 mg acetylsalicylic acid i. v. and 300 mg p. o. in ACS (ACUTE). Thromb Haemost 117:625–635

    Article  PubMed  Google Scholar 

  34. Montalescot G, van ’t Hof AW, Lapostolle F et al (2014) Prehospital ticagrelor in ST-segment elevation myocardial infarction. N Engl J Med 371:1016–1027

    Article  PubMed  Google Scholar 

  35. Sarafoff N, Martischnig A, Wealer J et al (2013) Triple therapy with aspirin, prasugrel, and vitamin K antagonists in patients with drug-eluting stent implantation and an indication for oral anticoagulation. J Am Coll Cardiol 61:2060–2066

    Article  CAS  PubMed  Google Scholar 

  36. Valgimigli M, Frigoli E, Leonardi S et al (2015) Bivalirudin or unfractionated heparin in acute coronary syndromes. N Engl J Med 373:997–1009

    Article  CAS  PubMed  Google Scholar 

  37. Shahzad A, Kemp I, Mars C et al (2014) Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention (HEAT-PPCI): an open-label, single centre, randomised controlled trial. Lancet 384:1849–1858

    Article  CAS  PubMed  Google Scholar 

  38. Bonaca MP, Bhatt DL, Cohen M et al (2015) Long-term use of ticagrelor in patients with prior myocardial infarction. N Engl J Med 372:1791–1800

    Article  PubMed  Google Scholar 

  39. Gibson CM, Mehran R, Bode C et al (2016) Prevention of bleeding in patients with atrial fibrillation undergoing PCI. N Engl J Med 375:2423–2434

    Article  CAS  PubMed  Google Scholar 

  40. Dewilde WJ, Oirbans T, Verheugt FW et al (2013) Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial. Lancet 381:1107–1115

    Article  CAS  PubMed  Google Scholar 

  41. Pizarro G, Fernández-Friera L, Fuster V et al (2014) Long-term benefit of early pre-reperfusion metoprolol administration in patients with acute myocardial infarction: results from the METOCARD-CNIC trial (effect of Metoprolol in cardioprotection during an acute myocardial infarction). J Am Coll Cardiol 63:2356–2362

    Article  CAS  PubMed  Google Scholar 

  42. Ibanez B, Macaya C, Sánchez-Brunete V et al (2013) ST-segment-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. The effect of Metoprolol in cardioprotection during an acute myocardial infarction (METOCARD-CNIC) trial. Circulation 3:1495–1503

    Article  Google Scholar 

  43. Roolvink V, Ibáñez B, Ottervanger JP et al (2016) Early intravenous beta-blockers in patients with ST-segment elevation myocardial infarction before primary percutaneous coronary intervention. J Am Coll Cardiol 67:2705–2715

    Article  CAS  PubMed  Google Scholar 

  44. Anonymous (2005) COMMIT (ClOpidogrel and Metoprolol in Myocardial Infarction Trial). Early intravenous then oral metoprolol in 45852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet 366:1622–1632

    Article  Google Scholar 

  45. Niccoli G, Scalone G, Crea F (2015) Acute myocardial infarction with no obstructive coronary atherosclerosis: mechanisms and management. Eur Heart J 36:475–481

    Article  PubMed  Google Scholar 

  46. Pasupathy S, Air T, Dreyer RP et al (2015) Systematic review of patients presenting with suspected myocardial infarction and nonobstructive coronary arteries. Circulation 131:861–870

    Article  CAS  PubMed  Google Scholar 

  47. Agewall S, Beltrame JF, Reynolds HR et al (2017) ESC working group position paper on myocardial infarction with non-obstructive coronary arteries. Eur Heart J 38:143–153

    PubMed  Google Scholar 

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J. Hinkelbein, Köln

Dieser Beitrag basiert in Teilen auf Thiele H, Desch S, de Waha S (2017) Akuter Myokardinfarkt bei Patienten mit ST-Strecken-Hebungs-Infarkt. Herz https://doi.org/10.1007/s00059-017-4641-7.

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Thiele, H. Empfehlungen der Europäischen Gesellschaft für Kardiologie-Leitlinien 2017 – STEMI. Notfall Rettungsmed 21, 22–33 (2018). https://doi.org/10.1007/s10049-017-0402-7

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