Notfall + Rettungsmedizin

, Volume 20, Issue 3, pp 199–205 | Cite as

Infektionen nach Organtransplantation

Leitthema
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Zusammenfassung

Durch den Einsatz potenter Immunsuppressiva steigen die Raten erfolgreicher Organtransplantationen, allerdings auch die Infektionsrisiken. Die Pathogene können aus der Prätransplantationszeit mitgebracht (endogene Reaktivierung), durch das Spenderorgan übertragen oder neu erworben sein. Unter Immunsuppression kann sowohl eine milde klinische Symptomatik als auch eine atypische Laborkonstellation Infekte maskieren. Wichtig ist es, frühzeitig eine gezielte Diagnostik einzuleiten und an seltene Erreger zu denken, die mit mikrobiologischen Standardverfahren oft nicht erfasst werden.

Schlüsselwörter

Prätransplantationszeit Opportunistische Infektion Spenderassoziierte Infektion Virale Reaktivierung Immunsuppression 

Infections after solid organ transplantation

Abstract

Potent immunosuppressive therapies increased the rate of successful solid organ transplantations, but are also associated with augmented risk for infections. The pathogens can originate from the pretransplant period (endogenous reactivation), donor-derived, or newly acquired. Immunosuppression can disguise infection by mild clinical symptoms and atypical laboratory constellation. Therefore, it is important to consider early in the process a systematic diagnostic workflow including rare pathogens which are sometimes not detectable by routine methods.

Keywords

Pretransplant period Opportunistic infections Donor-derived infection Viral reactivation Immunosuppression 

Notes

Danksagung

Die Autoren danken Herrn PD Dr. med. Peter Hunold, Klinik für Radiologie und Nuklearmedizin und Frau Dr. med. Christiane Kümpers, Institut für Pathologie, UKSH, Campus Lübeck, für die freundliche Zur Verfügung Stellung der Abbildungen.

Einhaltung ethischer Richtlinien

Interessenkonflikt

F. Cakiroglu, J. Rupp und M. Nitschke geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Medizinische Klinik I, Nephrologie und TransplantationUniversitätsklinikum Schleswig-Holstein, Campus LübeckLübeckDeutschland
  2. 2.Klinik für Infektiologie und MikrobiologieUniversitätsklinikum Schleswig-Holstein, Campus LübeckLübeckDeutschland

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