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Polygenic variants related to familial hypobetalipoproteinemia in a patient with Alzheimer’s disease homozygotic for the APOE ε2 allele presenting multiple cortical superficial siderosis and recurrent lobar hemorrhages

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Fig. 1

Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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References

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Funding

This work was supported by the KAKENHI program of the Japan Society for the Promotion of Science (Grant Numbers: JP18K07491 (M. I.), JP19K07411 (H. Y.), JP19H03712 (S. I.), and JP19K07813 (Y. I.)) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

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Authors and Affiliations

  1. Division of General Education (Neurology), Faculty of Health & Medical Care, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama, 350-1241, Japan

    Masaki Ikeda

  2. Department of Neurology, Geriatrics Research Institute and Hospital, 3-26-8 Odomomachi, Maebashi, Gunma, 371-0847, Japan

    Masaki Ikeda, Koichi Okamoto & Masakuni Amari

  3. Department of Neurology, Gunma University Graduate School of Medicine, 3-29-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan

    Masaki Ikeda, Eriko Takai & Yoshio Ikeda

  4. Department of Pathology, Geriatrics Research Institute and Hospital, 3-26-8 Odomomachi, Maebashi, Gunma, 371-0847, Japan

    Keiji Suzuki

  5. Department of Internal Medicine, Geriatrics Research Institute and Hospital, 3-26-8 Odomomachi, Maebashi, Gunma, 371-0847, Japan

    Masamitsu Takatama

  6. Department of Pathology, Gunma University Graduate School of Medicine, 3-29-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan

    Hideaki Yokoo

  7. Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsukeshi, Tochigi, 329-0498, Japan

    Shun Ishibashi

Authors
  1. Masaki Ikeda
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  2. Koichi Okamoto
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  3. Keiji Suzuki
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  4. Masakuni Amari
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  5. Eriko Takai
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  6. Masamitsu Takatama
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  7. Hideaki Yokoo
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  8. Shun Ishibashi
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  9. Yoshio Ikeda
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Corresponding author

Correspondence to Masaki Ikeda.

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Ethics approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Geriatrics Research Institute and Hospital (No. 52) and the Human Genome/Gene Analysis Research Ethics Committee of Gunma University (No. 62).

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Informed consent was obtained from the patient and the family members.

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The patient and the family members have consented to the submission of the case report.

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The authors declare no competing interests.

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Ikeda, M., Okamoto, K., Suzuki, K. et al. Polygenic variants related to familial hypobetalipoproteinemia in a patient with Alzheimer’s disease homozygotic for the APOE ε2 allele presenting multiple cortical superficial siderosis and recurrent lobar hemorrhages. Neurogenetics 23, 69–71 (2022). https://doi.org/10.1007/s10048-021-00672-3

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