References
Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, Donaldson D, Goto J, O'Regan JP, Deng HX, et al (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis (published erratum appears in Nature 1993 364:362). Nature 362:59–62
Suthers G, Laing N, Wilton S, Dorosz S, Waddy H (1994) "Sporadic" motoneuron disease due to familial SOD1 mutation with low penetrance. Lancet 344:1773–1773
Jackson M, Al-Chalabi A, Enayat ZE, Chioza B, Leigh PN, Morrison KE (1997) Copper/zinc superoxide dismutase 1 and sporadic amyotrophic lateral sclerosis: analysis of 155 cases and identification of a novel insertion mutation. Ann Neurol 42:803–807
Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, Brown RH, Jr., Scherer SW, Rouleau GA, Hayden MR, Ikeda JE (2001) A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. Nat Genet 29:166–173
Yang Y, Hentati A, Deng HX, Dabbagh O, Sasaki T, Hirano M, Hung WY, Ouahchi K, Yan J, Azim AC, Cole N, Gascon G, Yagmour A, Ben Hamida M, Pericak-Vance M, Hentati F, Siddique T (2001) The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis. Nat Genet 29:160–165
Barcellos LF, Klitz W, Field LL, Tobias R, Bowcock AM, Wilson R, Nelson MP, Nagatomi J, Thomson G (1997) Association mapping of disease loci, by use of a pooled DNA genomic screen. Am J Hum Genet 61:734–747
Xie X, Ott J (1993) Testing linkage disequilibrium between a disease gene and marker loci. Am J Hum Genet 53:1107–1107
Sham PC, Curtis D (1995) Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet 59:97–105
Acknowledgements
A.A.C. is a Medical Research Council (MRC) Clinician Scientist. V.H. is funded by the MRC. C.S. is funded by GKT Medical School. We wish to thank the Motor Neurone Disease Association, Muscular Dystrophy Association, Project ALS, ALS Association, and the Angel Fund. R.B. also receives generous funding from the National Institutes of Health (NINDS and NIA).
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Al-Chalabi, A., Hansen, V.K., Simpson, C.L. et al. Variants in the ALS2 gene are not associated with sporadic amyotrophic lateral sclerosis. Neurogenetics 4, 221–222 (2003). https://doi.org/10.1007/s10048-003-0152-1
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DOI: https://doi.org/10.1007/s10048-003-0152-1