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Immunoglobulin KM genes in Guillain-Barré syndrome

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Abstract

Guillain-Barré syndrome is associated with antecedent Campylobacter jejuni infection. Only a minority of the infected individuals, however, develops the disease, implying a role for genetic factors in conferring susceptibility. To determine the role of immunoglobulin KM genes (genetic markers of the constant region of κ chains) in the etiology of this syndrome, we genotyped 83 patients and 196 healthy controls from Norway for KM1 and KM3 alleles by polymerase chain reaction-restriction fragment length polymorphism. The frequency of KM3 homozygotes was significantly increased in patients compared with controls (86.7% vs. 74%, P=0.01, odds ratio=2.3). Conversely, the frequency of KM1/KM3 heterozygotes was significantly decreased in patients compared with controls (13.3% vs. 26%, P=0.01, odds ratio=0.4). These results suggest that KM genes may be relevant to the etiology of Guillain-Barré syndrome.

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Acknowledgements

This study was supported in part by funds from the U.S. Department of Energy cooperative agreement DE-FC02–02CH11109, Odd Fellow Norway, Norwegian Society of MS, and Kjell Almes Legacy. We thank Mr. Keith Rocca for expert technical assistance.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29425–2230, USA

    Janardan P. Pandey

  2. Department of Neurology, Haukeland Hospital, University of Bergen, 5021 Bergen, Norway

    Christian A. Vedeler

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  1. Janardan P. Pandey
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  2. Christian A. Vedeler
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Correspondence to Janardan P. Pandey.

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Pandey, J.P., Vedeler, C.A. Immunoglobulin KM genes in Guillain-Barré syndrome. Neurogenetics 4, 147–149 (2003). https://doi.org/10.1007/s10048-003-0144-1

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  • DOI: https://doi.org/10.1007/s10048-003-0144-1

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