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Patient management important for long-term support beyond 5 years in the BTT: republication of the article published in the Japanese Journal of Artificial Organs

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  • Artificial Heart (Clinical)
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Abstract

Heart transplantation is considered to be the best treatment for severe heart failure refractory to medical therapy, improving patients' survival and quality of life (QOL). However, the number of donors is smaller than the number of registered applicants for heart transplantation, which increases every year, and the waiting period for heart transplantation has been extended to more than 1700 days by 2022. Since 2011, reimbursement for the implantable left ventricular assist device (iLVAD) was established. The numbers of the iLVAD patients have been increasing year by year. Patients are managed at home with an iLVAD and can live with their families and even return to work, depending on the situation. On the other hand, self-management at home, including caregivers, is important for a safe life. Home management beyond 5 years is becoming more common due to long waiting time for transplant. This article outlines the important aspects of patient management for long-term support. This review was created based on a translation of the Japanese review written in the Japanese Journal of Artificial Organs in 2023 (Vol. 52, No. 1, pp. 62–66), with some modifications.

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References

  1. The Japanese Society for Heart Transplantation: Japanese Registry for Heart Transplantation, Aug 2022. http://www.jsht.jp/registry/japan/. Accessed 1 Feb 2023.

  2. The Japanese Association for Thoracic Surgery: J-MACS Statistical Report. 2023. https: //www.jpats.org/society/jmacs/report.html. Accessed 1 Feb 2023.

  3. Mehra MR, Uriel N, Naka Y, et al. Momentum 3 investigators: a fully magnetically levitated left ventricular assist device—final report. N Engl J Med. 2019;380:1618–27.

    Article  PubMed  Google Scholar 

  4. Mehra MR, Naka Y, Uriel N, et al. Momentum 3 investigators: a fully magnetically levitated circulatory pump for advanced heart failure. N Engl J Med. 2017;376:440–50.

    Article  PubMed  Google Scholar 

  5. Moazami N, Milano CA, John R, et al. HeartMate II investigators: pump replacement for left ventricular assist device failure can be done safely and is associated with low mortality. Ann Thorac Surg. 2013;95:500–5.

    Article  PubMed  Google Scholar 

  6. Kusne S, Mooney M, Danziger-Isakov L, et al. An ISHLT consensus document for prevention and management strategies for mechanical circulatory support infection. J Heart Lung Transplant. 2017;36:1137–53.

    Article  PubMed  Google Scholar 

  7. Mutsuga M, Okumura T, Morimoto R, et al. Impact of an improved driveline management for HeartMate II and HeartMate 3 left ventricular assist devices. Artif Organs. 2023;47:387–95.

    Article  CAS  PubMed  Google Scholar 

  8. Cannon A, Elliott T, Ballew C, et al. Variability in infection control measures for the percutaneous lead among programs implanting long-term ventricular assist devices in the United States. Prog Transplant. 2012;22:351–9.

    Article  PubMed  Google Scholar 

  9. Slaughter MS, Pagani FD, Rogers JG, et al. HeartMate II clinical investigators: clinical management of continuous-flow left ventricular assist devices in advanced heart failure. J Heart Lung Transplant. 2010;29:S1-39.

    Article  PubMed  Google Scholar 

  10. Kormos RL Holman W Chapter 13: Adverse events and complications of mechanical circulatory support Mechanical circulatory support: a companion to Braunwald’s heart disease editors Kormos RL Miller LW Elsevier Amsterdam 166–82 2012

  11. Frontera JA, Starling R, Cho SM, et al. Risk factors, mortality, and timing of ischemic and hemorrhagic stroke with left ventricular assist devices. J Heart Lung Transplant. 2017;36:673–83.

    Article  PubMed  Google Scholar 

  12. Moazami N, Smedira NG, McCarthy PM, et al. Safety and efficacy of intraarterial thrombolysis for perioperative stroke after cardiac operation. Ann Thorac Surg. 2001;72:1933–9.

    Article  CAS  PubMed  Google Scholar 

  13. Kitano T, Sakaguchi M, Yamagami H, et al. Mechanical thrombectomy in acute ischemic stroke patients with left ventricular assist device. J Neurol Sci. 2020;418:117142.

    Article  PubMed  Google Scholar 

  14. John R, Kamdar F, Eckman P. Lessons learned from experience with over 100 consecutive HeartMate II left ventricular assist devices. Ann Thorac Surg. 2011;92:1593–9.

    Article  PubMed  Google Scholar 

  15. Morgan JA, Paone G, Nemeh HW, et al. Gastrointestinal bleeding with the HeartMate II left ventricular assist device. J Heart Lung Transplant. 2012;31:715–8.

    Article  PubMed  Google Scholar 

  16. Kushnir VM, Sharma S, Ewald GA, et al. Evaluation of GI bleeding after implantation of left ventricular assist device. Gastrointest Endosc. 2012;75:973–9.

    Article  PubMed  Google Scholar 

  17. Imamura T, Kinugawa K, Nitta D, et al. Opening of aortic valve during exercise is key to preventing development of aortic insufficiency during ventricular assist device treatment. ASAIO J. 2015;61:514–9.

    Article  PubMed  Google Scholar 

  18. Imamura T, Kinugawa K, Nitta D, et al. Advantage of pulsatility in left ventricular reverse remodeling and aortic insufficiency prevention during left ventricular assist device treatment. Circ J. 2015;79:1994–9.

    Article  PubMed  Google Scholar 

  19. Sayer G, Sarswat N, Kim GH, et al. The hemodynamic effects of aortic insufficiency in patients supported with continuous-flow left ventricular assist devices. J Card Fail. 2017;23:545–51.

    Article  PubMed  Google Scholar 

  20. Truby LK, Garan AR, Givens RC, et al. Aortic insufficiency during contemporary left ventricular assist device support: analysis of the INTERMACS registry. JACC Heart Fail. 2018;6:951–60.

    Article  PubMed  PubMed Central  Google Scholar 

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  1. Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan

    Masato Mutsuga

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  1. Masato Mutsuga
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Mutsuga, M. Patient management important for long-term support beyond 5 years in the BTT: republication of the article published in the Japanese Journal of Artificial Organs. J Artif Organs (2024). https://doi.org/10.1007/s10047-024-01441-3

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