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Impact of delayed veno-venous extracorporeal membrane oxygenation weaning on postoperative rehabilitation of lung transplantation: a single-center comparative study

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  • Artificial Lung / ECMO
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Abstract

Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a reliable and effective extracorporeal life support during lung transplantation (LTx). However, the clinical benefit of delayed VV-ECMO weaning remains unclear. The current study aims to investigate whether delayed weaning of VV-ECMO is more beneficial to the rehabilitation for lung transplant patients. Patients who underwent LTx with VV-ECMO between January 2017 and January 2019 were included. Enrollment of patients was suitable for weaning off ECMO immediately after surgery. Randomization was performed in the operating room. Postoperative outcomes were compared between the two groups. Besides, univariate and multivariable logistic regressions were performed to estimate risk of postoperative complications. Compared to VV-ECMO weaning immediately after LTx, delayed weaning was associated with shorter hospital length of stay (days, 31 vs. 46; P < 0.05), lower incidence of noninvasive ventilation (4.3% vs. 24.4%; P < 0.05), primary graft dysfunction (PGD) (6.4% vs. 29.3%; P < 0.05), atrial fibrillation (AF) (4.3% vs. 22%, P < 0.05), and respiratory failure (4.3% vs. 19.5%; P < 0.05). Multivariable logistic regressions revealed that VV-ECMO weaning after LTx was independently correlated with increased risk of developing PGD [odds ratio (OR), 5.97, 95% CI 1.16–30.74], AF (OR, 6.87, 95% CI 1.66–28.47) and respiratory failure (OR, 6.02, 95% CI 1.12–32.49) by comparison of delayed VV-ECMO weaning. Patients with delayed VV-ECMO weaning are associated with lower complications and short hospital length of stay, while it relates to longer mechanical ventilation. These findings suggest that delayed VV-ECMO after LTx can facilitate rehabilitation.

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Data availability

The data that support the findings of this study are available on request from the corresponding author (qcwucq@163.com). The data are not publicly available due to privacy or ethical restrictions.

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Author notes

  1. Lin-Jun Li, Hong-Yang Xu have contributed equally to this work and share first authorship.

Authors and Affiliations

  1. Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, NO. 01 You Yi Road, Chongqing, 400016, China

    Lin-Jun Li, Xiao-Wen Wang, Cheng Zhang, Ming Du & Qing-Chen Wu

  2. Department of Critical Care Medicine, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, 214043, Jiangsu, China

    Hong-Yang Xu & Ke Jin

  3. Department of Thoracic Surgery and Transplant Center, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, 214023, Jiangsu, China

    Jing-Yu Chen

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  1. Lin-Jun Li
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Contributions

Conception and design: L-JL and H-YX. Administrative support: Q-CW and J-YC. Provision of study materials or patients: KJ, H-YX. Collection and assembly of data: L-JL, CZ and H-YX. Data analysis and interpretation: L-JL, X-WW, MD and H-YX. Manuscript writing: All authors. Final approval of manuscript: All authors.

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Correspondence to Jing-Yu Chen or Qing-Chen Wu.

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Li, LJ., Xu, HY., Wang, XW. et al. Impact of delayed veno-venous extracorporeal membrane oxygenation weaning on postoperative rehabilitation of lung transplantation: a single-center comparative study. J Artif Organs 26, 303–308 (2023). https://doi.org/10.1007/s10047-022-01376-7

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  • DOI: https://doi.org/10.1007/s10047-022-01376-7

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