Skip to main content
SpringerLink
Log in

Usefulness of hybrid veno-arterial extracorporeal membrane oxygenation for lung ischemia–reperfusion injury after biventricular assist device implantation

  • Case Report
  • Artificial Heart (Clinical)
  • Published:
Journal of Artificial Organs Aims and scope Submit manuscript

Abstract

We experienced a case of fulminant myocarditis complicated by severe lung ischemia–reperfusion injury after switching from veno-arterial extracorporeal membrane oxygenation to biventricular assist device. We controlled lung blood flow by hybrid veno-arterial extracorporeal membrane oxygenation, which was established by modifying the biventricular assist device circuit without resternotomy, blood delivery to the pulmonary artery and blood removal from the left ventricle in addition to central veno-arterial extracorporeal membrane oxygenation, and accelerated lung recovery. The patient’s lung damage and cardiac function were restored, and she completely recovered and was discharged without any complications. Regulation of lung blood flow is important and effective for lung ischemia–reperfusion injury after biventricular assist device implantation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Kociol RD, Cooper LT, Fang JC, Moslehi JJ, Pang PS, Sabe MA, Shah RV, Sims DB, Thiene G, Vardeny O. American Heart Association Heart Failure and Transplantation Committee of the Council on Clinical Cardiology. Recognition and initial management of fulminant myocarditis. A Scientific statement from American Heart Association. Circulation. 2020;141:69–92.

    Article  Google Scholar 

  2. van Diepen S, Katz JN, Albert NM, Henry TD, Jacobs AK, Kapur NK, Kilic A, Menon V, Ohman EM, Sweitzer NK, Thiele H, Washam JB, Cohen MG, American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Quality of Care and Outcomes Research; and Mission: Lifeline. Contemporary management of cardiogenic shock: a scientific statement from the American Heart Association. Circulation. 2017;136:e232–68.

    Article  Google Scholar 

  3. Saito S, Toda K, Miyagawa S, Yoshioka Y, Hata H, Yoshioka D, Domae K, Tsukamoto Y, Sakata Y, Sawa Y. Diagnosis, medical treatment, and stepwise mechanical circulatory support for fulminant myocarditis. J Artif Organs. 2018;21:172–9.

    Article  Google Scholar 

  4. Laubach VE, Sharma AK. Mechanism of lung ischemia-reperfusion injury. Curr Opin Organ Transplant. 2016;21:246–52.

    Article  CAS  Google Scholar 

  5. Weyker PD, Webb CA, Kiamanesh D, Flynn BC. Lung ischemia reperfusion injury: a bench-to-bedside review. Semin Cardiothorac Vasc Anesth. 2013;17:28–43.

    Article  Google Scholar 

  6. den Hengst WA, Gielis JF, Lin JY, Van Schil PE, De Windt LJ, Moens AL. Lung ischemia-reperfusion injury: a molecular and clinical view on a complex pathophysiological process. Am J Physiol Heart Circ Physiol. 2010;299:H1283–99.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Department of Cardiothoracic Surgery, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakae-Cho Itabashi-ku, Tokyo, 173-0015, Japan

    Akiko Mano, Masaaki Ishii, Tomohiro Murata, Mitsuhiro Kawata & Shunei Kyo

  2. The Department of Cardiothoracic Surgery, University of Ehime, 454 Shizugawa, Toon-City, Ehime, 791-0295, Japan

    Takashi Nishimura

Authors
  1. Akiko Mano
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takashi Nishimura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Masaaki Ishii
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tomohiro Murata
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mitsuhiro Kawata
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Shunei Kyo
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

All authors have read the manuscript and have agreed with submission. Contributions of our authors are following: AM: patient’s care, collection and analysis of data, manuscript writing. TN: patient’s care. MI: patient’s care. TM: patient’s care. MK: patient’s care. SK: supervision.

Corresponding authors

Correspondence to Akiko Mano or Takashi Nishimura.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mano, A., Nishimura, T., Ishii, M. et al. Usefulness of hybrid veno-arterial extracorporeal membrane oxygenation for lung ischemia–reperfusion injury after biventricular assist device implantation. J Artif Organs 25, 266–269 (2022). https://doi.org/10.1007/s10047-022-01310-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10047-022-01310-x

Keywords

Search

Navigation