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Pediatric patient with restrictive cardiomyopathy on staged biventricular assist device support with Berlin Heart EXCOR® underwent heart transplantation successfully: the first case in Japan

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  • Artificial Heart (Clinical)
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Abstract

Abstract

Pure restrictive cardiomyopathy is a strong risk factor for poor outcomes in children with cardiomyopathy on ventricular assist devices. Owing to concomitant right heart failure, children with end-staged restrictive cardiomyopathy who are supported with a ventricular assist device often require a biventricular assist device, which is another risk factor for waitlist mortality in heart transplantation candidates. Herein, we report the case of a 3-year-old boy with pure restrictive cardiomyopathy who successfully underwent heart transplantation after 12 months of support with staged biventricular assist devices. Owing to the progression of diastolic dysfunction, the left ventricular assist device could not provide adequate circulation support. Despite the provision of biventricular assist device support, the patient required a complex management strategy that involved balancing the left and right ventricular assist device supports. We were able to stabilize the patient by careful synchronization of the supports and proceeded to heart transplantation.

Trial registration

Clinical Registration No.: Institutional Review Board of Osaka University Hospital, approval no. 16105.

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Acknowledgments

The authors would like to thank Editage (www.editage.jp) for English language editing.

Funding

This study received no financial support.

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Authors and Affiliations

  1. Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Kanta Araki, Takayoshi Ueno, Masaki Taira, Tomomitsu Kanaya, Takuji Watanabe, Yuji Tominaga, Koichi Toda, Toru Kuratani & Yoshiki Sawa

  2. Department of Pediatrics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Ryo Ishii, Hidekazu Ishida & Jun Narita

Authors
  1. Kanta Araki
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  2. Takayoshi Ueno
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  3. Masaki Taira
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  4. Tomomitsu Kanaya
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  5. Takuji Watanabe
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  6. Yuji Tominaga
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  7. Ryo Ishii
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  8. Hidekazu Ishida
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  9. Jun Narita
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  10. Koichi Toda
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  11. Toru Kuratani
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  12. Yoshiki Sawa
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by KA. The first draft of the manuscript was written by KA, and all authors commented on the previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Kanta Araki or Yoshiki Sawa.

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The authors declare that they have no conflict of interest.

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Araki, K., Ueno, T., Taira, M. et al. Pediatric patient with restrictive cardiomyopathy on staged biventricular assist device support with Berlin Heart EXCOR® underwent heart transplantation successfully: the first case in Japan. J Artif Organs 24, 269–272 (2021). https://doi.org/10.1007/s10047-020-01208-6

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  • DOI: https://doi.org/10.1007/s10047-020-01208-6

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