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Anatomical study of the Cleveland Clinic continuous-flow total artificial heart in adult and pediatric configurations

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  • Artificial Heart (Basic)
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Abstract

The purpose of this study was to assess the smallest possible body sizes of patients in whom the Cleveland Clinic continuous-flow total artificial heart for adult (CFTAH) and pediatric configurations (P-CFTAH) can fit. One of the most critical dimensions is the vertebra-to-sternum distance at the junction of the right atrium to the inferior vena cava (V–S distance). Our previous CFTAH anatomical fitting study suggested that the CFTAH would fit patients of V–S distance ≥ 7.5 cm and the P-CFTAH of V–S distance ≥ 5.25 cm (70% of 7.5 cm). To confirm this, we assessed the relationship between body surface area (BSA) and V–S distance in 15 adult patients (BSA 1.86–2.62 m2) and 31 pediatric patients (BSA 0.17–1.80 m2) whose computed tomography scans were available. We found a highly significant correlation between BSA and V–S distance (p < 1.0 × 10−25). It appears that the CFTAH will fit in most patients with BSA ≥ 1.0 m2 (corresponding height of ≥ 130 cm and age of 9 years) and the P-CFTAH in patients with BSA ≥ 0.3 m2 (corresponding height of ≥ 55 cm and age of 1 month). Further anatomical fitting studies are needed to evaluate the two pump models inside human chests to determine the smallest patient size/critical dimensions and device port configurations.

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Acknowledgements

This study was supported by Cleveland Clinic internal funding. All authors had freedom of investigation and full control of the design of the study, methods used, outcome parameters and results, analysis of data, and production of the written report.

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Authors and Affiliations

  1. Department of Biomedical Engineering/ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Kiyotaka Fukamachi, Jamshid H. Karimov, Nicole A. Byram, Gengo Sunagawa, Raymond Dessoffy & Takuma Miyamoto

  2. R1 Engineering, Euclid, OH, USA

    David J. Horvath

Authors
  1. Kiyotaka Fukamachi
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  2. Jamshid H. Karimov
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  3. Nicole A. Byram
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  4. Gengo Sunagawa
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  5. Raymond Dessoffy
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  6. Takuma Miyamoto
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  7. David J. Horvath
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Contributions

KF: study design, data analysis, supervision, drafting the manuscript, and principal investigator. JHK, NB, GS, and TM: study design and data analysis. DJH: device inventor.

Corresponding authors

Correspondence to Kiyotaka Fukamachi or Jamshid H. Karimov.

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Conflict of interest

David J. Horvath is an inventor of the adult continuous-flow total artificial heart. The technology was licensed to Cleveland Heart, Inc., a Cleveland Clinic spin-off company. If the total artificial heart is successful, the inventors and Cleveland Clinic may benefit. None of the other authors has a financial interest or other potential conflict of interest related to the subject matter or materials mentioned in the manuscript.

Additional information

Inventor and coauthor D. J. Horvath, formerly of the Department of Biomedical Engineering, is now a consultant.

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Fukamachi, K., Karimov, J.H., Byram, N.A. et al. Anatomical study of the Cleveland Clinic continuous-flow total artificial heart in adult and pediatric configurations. J Artif Organs 21, 383–386 (2018). https://doi.org/10.1007/s10047-018-1039-0

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  • DOI: https://doi.org/10.1007/s10047-018-1039-0

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