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Application of actuator-driven pulsed water jet for coronary artery bypass grafting: assessment in a swine model

Journal of Artificial Organs volume 21, pages 247–253 (2018)Cite this article

Abstract

Actuator-driven pulsed water-jet (ADPJ) dissection is an emerging surgical method for dissecting tissue without heat and mechanical injury to vessels. We elucidated the mechanical properties of the piezo ADPJ and evaluated its usefulness and safety in coronary artery bypass grafting procedures. The relationship between the input voltage (10–100 V) and peak pressure of the pulsed water jet was evaluated. The tissue strengths of swine internal thoracic and coronary arteries and the surrounding tissues were measured to assure tissue-selective dissection. Internal thoracic arteries were harvested by conventional electric cautery and the water jet in four swine, and eight coronary arteries surrounded by myocardium were attempted to be exposed with the water jet. The dissected specimens were histologically evaluated. The peak pressure of the pulsed water jet was positively correlated with the input voltage (R 2 = 0.9984, P < 0.001). The breaking strengths of the target vessels (internal thoracic and coronary arteries) and the surrounding tissues were significantly different (P = 0.002 and P < 0.001, respectively). Histologic examination revealed that internal thoracic arteries were isolated with less heat damage using the pulsed water jet (P = 0.002) compared with electric cautery, and coronary arteries also were dissected without apparent histologic damage. ADPJ has the possibility of assuring tissue selectivity among the internal thoracic and coronary arteries. The results also indicated that the use of ADPJ may enhance safe procedures to harvest grafts during coronary artery bypass grafting.

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Acknowledgements

The authors appreciate the assistance of Teruko Sueta and Nobuko Hashimoto from the Center for Laboratory Animal Research, Tohoku University, and Ayako Ono from the experimental laboratory at the Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine for technical assistance. The authors thank Mr. Takeshi Seto and Mr. Yasuyoshi Hama for preparing the surgical instruments. The authors thank Dr. Yuriko Saiki for her expertise with histopathological assessment and Ms. Asaka Ishigamori for administrative assistance.

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Affiliations

  1. Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, Sendai, Miyagi, Japan

    Tomoyuki Suzuki, Shunsuke Kawamoto, Masatoshi Akiyama, Osamu Adachi, Kiichiro Kumagai & Yoshikatsu Saiki

  2. Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan

    Atsuhiro Nakagawa, Toshiki Endo & Teiji Tominaga

Authors
  1. Tomoyuki Suzuki
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  2. Shunsuke Kawamoto
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  3. Atsuhiro Nakagawa
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  4. Toshiki Endo
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  5. Teiji Tominaga
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  6. Masatoshi Akiyama
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  7. Osamu Adachi
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  8. Kiichiro Kumagai
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  9. Yoshikatsu Saiki
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Corresponding authors

Correspondence to Tomoyuki Suzuki or Yoshikatsu Saiki.

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Funding

This work was supported in part by the Translational Research Network Program, B13, Grants-in Aid for Scientific Research (C) (26462196, 26462197, 24592049, and 15K10353), (A) (15H01707), and (B) (26282116 and 15H04945) from the Japanese Ministry of Education, Culture, Sports, Science, and Technology. The piezo ADPJ system was supplied by Seiko Epson Corporation as part of a collaborative research contract with Tohoku University.

Conflict of interest

Nakagawa and Tominaga received research funding support from Seiko Epson Co., Ltd. under a collaborative research contract with Tohoku University; otherwise, none were reported.

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Suzuki, T., Kawamoto, S., Nakagawa, A. et al. Application of actuator-driven pulsed water jet for coronary artery bypass grafting: assessment in a swine model. J Artif Organs 21, 247–253 (2018). https://doi.org/10.1007/s10047-017-1008-z

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  • DOI: https://doi.org/10.1007/s10047-017-1008-z

Keywords

  • Piezo
  • Pulsed water jet
  • Internal thoracic artery
  • Coronary artery
  • Cardiovascular surgery