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Numerical investigation of oxygen transport by hemoglobin-based carriers through microvessels

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Abstract

The small size of hemoglobin-based oxygen carriers (HBOCs) may expand the realm of new treatment possibilities for various circulatory diseases. The parametric evaluation of HBOC performance for oxygen transport within tissue is essential for effectively characterizing its performance for each circulatory disease assessed. Thus, the overarching objective of this present study was to numerically investigate the reaction–diffusion phenomenon of oxygenated HBOCs and oxygen on tissues through microvessels. We considered dissociation rate coefficients, oxygen affinity, and diffusion coefficients due to Brownian motion as the biophysical parameters for estimating HBOC performance for oxygen transport. A two-dimensional computational domain, including vessel and tissue regions, was, therefore, accordingly assumed. It was observed that HBOC flows in a microvessel with a diameter of 25 μm and a length of 1 mm, and that the dissociated oxygen diffuses to the tissue region. The results indicated that oxyhemoglobin saturation and partial oxygen tension in a downstream region changed according to each biophysical parameter of HBOC. Moreover, the change in oxygen consumption rate in the tissue region had considerable influence on the oxyhemoglobin saturation level within the vessel. Comparison between simulation results and existing in vitro experimental data of actual HBOCs and RBC showed qualitatively good agreement. These results provide important information for the effective design of robust HBOCs in future.

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Acknowledgements

This research was partially supported by MEXT SPIRE Supercomputational Life Science.

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Authors and Affiliations

  1. Faculty of Engineering, Yokohama National University, 79-5, Hodogaya, Yokohama, 240-8501, Japan

    Toru Hyakutake

  2. Graduate School of Engineering, Yokohama National University, 79-5, Hodogaya, Yokohama, 240-8501, Japan

    Takumi Kishimoto

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  1. Toru Hyakutake
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  2. Takumi Kishimoto
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Correspondence to Toru Hyakutake.

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The authors confirmed that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.

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Hyakutake, T., Kishimoto, T. Numerical investigation of oxygen transport by hemoglobin-based carriers through microvessels. J Artif Organs 20, 341–349 (2017). https://doi.org/10.1007/s10047-017-0974-5

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  • DOI: https://doi.org/10.1007/s10047-017-0974-5

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