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Generating pulsatility by pump speed modulation with continuous-flow total artificial heart in awake calves

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  • Artificial Heart (Basic)
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Abstract

The purpose of this study was to evaluate the effects of sinusoidal pump speed modulation of the Cleveland Clinic continuous-flow total artificial heart (CFTAH) on hemodynamics and pump flow in an awake chronic calf model. The sinusoidal pump speed modulations, performed on the day of elective sacrifice, were set at ±15 and ± 25% of mean pump speed at 80 bpm in four awake calves with a CFTAH. The systemic and pulmonary arterial pulse pressures increased to 12.0 and 12.3 mmHg (±15% modulation) and to 15.9 and 15.7 mmHg (±25% modulation), respectively. The pulsatility index and surplus hemodynamic energy significantly increased, respectively, to 1.05 and 1346 ergs/cm at ±15% speed modulation and to 1.51 and 3381 ergs/cm at ±25% speed modulation. This study showed that it is feasible to generate pressure pulsatility with pump speed modulation; the platform is suitable for evaluating the physiologic impact of pulsatility and allows determination of the best speed modulations in terms of magnitude, frequency, and profiles.

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Acknowledgements

This work was supported with federal funding obtained from the National Heart, Lung and Blood Institute and the National Institutes of Health (Bethesda, Maryland, USA), under grant 5R01HL096619 (to LARG and KF).

Author information

Authors and Affiliations

  1. Cardiovascular Dynamics Laboratory, Department of Biomedical Engineering/ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    Kiyotaka Fukamachi, Jamshid H. Karimov, Gengo Sunagawa, David J. Horvath, Nicole Byram, Raymond Dessoffy, Leonard A. R. Golding & Nader Moazami

  2. R1 Engineering, Cleveland, OH, USA

    David J. Horvath

  3. Electronics Core, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA

    Barry D. Kuban

  4. Department of Cardiothoracic Anesthesiology, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA

    Shiva Sale

  5. Department of Thoracic and Cardiovascular Surgery, Kaufman Center for Heart Failure, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA

    Nader Moazami

Authors
  1. Kiyotaka Fukamachi
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  2. Jamshid H. Karimov
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  3. Gengo Sunagawa
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  4. David J. Horvath
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  5. Nicole Byram
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  6. Barry D. Kuban
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  7. Raymond Dessoffy
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  8. Shiva Sale
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  9. Leonard A. R. Golding
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  10. Nader Moazami
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Corresponding authors

Correspondence to Kiyotaka Fukamachi or Jamshid H. Karimov.

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Conflict of interest

David Horvath, Barry Kuban, and Leonard A.R. Golding are inventors of the continuous-flow total artificial heart. The technology was licensed to Cleveland Heart, Inc., a Cleveland Clinic spin-off company. None of the other authors have a financial interest or other potential conflict of interest related to subject matter or materials mentioned in the manuscript.

Additional information

Coauthors LARG and DJH of the Department of Biomedical Engineering recently retired from the department.

Presented at the 36th Annual Meeting of International Society for Heart and Lung Transplantation, April 27–30, 2016, Washington, DC, USA.

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Fukamachi, K., Karimov, J.H., Sunagawa, G. et al. Generating pulsatility by pump speed modulation with continuous-flow total artificial heart in awake calves. J Artif Organs 20, 381–385 (2017). https://doi.org/10.1007/s10047-017-0958-5

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  • DOI: https://doi.org/10.1007/s10047-017-0958-5

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