Abstract
Although there are extensive published data regarding venous–arterial (VA) ECMO, particularly in the pediatric population, there is a paucity of data (mainly including case reports and observational studies) delineating the role of echocardiography in the management of adult patients supported by venous–venous (VV) ECMO. The present review is aimed at specifically addressing the rationale for echocardiography use in patients supported by VV-ECMO and at summarizing the available evidence on this topic. Based on the available evidence and on the experience of our group, practical considerations on the use of echocardiography in adult patients on VV-ECMO support are reported. To date, echocardiography is mainly used for selecting the type of ECMO (VA vs VV), monitoring cannulation and the early detection of complications, but it is underused in patients supported by VV-ECMO. Nevertheless, in these patients, this methodology can provide useful information in monitoring cardiac function, cannula positioning, pericardial fluid (for early detection of tamponade) during ECMO support, and therefore it can contribute to the integrated assessment and management of these complex patients. There is a clinical need to elaborate shared protocols for echocardiography use during VV ECMO support, particularly at this time when advanced echocardiography is gaining interest among intensivists.
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Abbreviations
- ECMO:
-
Extracorporeal membrane exygenation
- VA:
-
Veno-arterial
- VV:
-
Venous–venous
- TEE:
-
Transesopheageal
- TTE:
-
Transthoracic
- IVC:
-
Inferior vena cava
- SVC:
-
Superior vena cava
- RV:
-
Right ventricle
- LV:
-
Left ventricle
- ICU:
-
Intensive care unit
Reference
Platts DG, Sedgwick JF, Burstow DJ, Mullany DV, Fraser JF. The role of echocardiography in the management of patients supported by extracorporeal membrane oxygenation. J Am Soc Echocardiogr. 2012;25:131–41.
MacLaren G, Combes A, Bartlett RH. Contemporary extracorporeal membrane oxygenation for adult respiratory failure: life support in the new era. Intensive Care Med. 2012;38(2):210–20.
Bartlett RH, Gattinoni L. Current status for extracorporeal life support (ECMO) for cardiopulmonary failure. Minerva Anesthesiol. 2010;76:534–40.
Abrams D, Combes A, Brodie D. Extracorporeal Membrane oxygenation in cardiopulmonary disease in adults. JACC. 2014;63:769–78.
Mullany D, Shkar K, Platts D, Fraser J. The rapidly evolving use of ECLS in adults. Heart Lung Circ. 2014;. doi:10.1016/j.hlc.2014.04.009.
Sedgwick JF, Burstow DJ, Platts DG. The role of echocardiography in the management of patients supported by extracorporeal membranous oxygenation (ECMO). Int J Cardiol. 2010;147(suppl):S16.
Thomas TH, Price R, Ramaciotti C, Thompson M, Megison S, Lemler MS. Echocardiography, not chest radiography, for evaluation of cannula placement during pediatric extracorporeal membrane oxygenation. Pediatr Crit Care Med. 2009;10:56–99.
Strieper MJ, Sharma S, Dooley KJ, Cornish JD, Clark R. Effects of venovenous extracorporeal membrane oxygenation on cardiac performance as determined by echocardiographic measurements. J Pediatr. 1993;122:950–5.
Migliaccio ML, Zagli G, Cianchi G, Lazzeri C, Bonizzoli M, Cecchi A, Anichini V, Gensini GF, Peris A. Extracorporeal membrane oxygenation in brain-death organ and tissues donors: a single-centre experience. Br J Anaesth. 2013;111(4):673–4.
Peris A, Zagli G, Cianchi G, Lazzeri C, Sani G, Bonizzoli M. Iliopsoas haematoma: unexpected life-threatening complication during extracorporeal membrane oxygenation support in H1N1-induced acute respiratory distress syndrome patients. Br J Anaesth. 2011;107(5):819–20.
Ciapetti M, Cianchi G, Zagli G, Greco C, Pasquini A, Spina R, Batacchi S, Bonizzoli M, Bonacchi M, Lazzeri C, Bernardo P, Peris A. Feasibility of inter-hospital transportation using extra-corporeal membrane oxygenation (ECMO) support of patients affected by severe swine-flu(H1N1)-related ARDS. Scand J Trauma Resusc Emerg Med. 2011;19:32.
Cianchi G, Bonizzoli M, Pasquini A, Bonacchi M, Zagli G, Ciapetti M, Sani G, Batacchi S, Biondi S, Bernardo P, Lazzeri C, Giovannini V, Azzi A, Abbate R, Gensini G, Peris A. Ventilatory and ECMO treatment of H1N1-induced severe respiratory failure: results of an Italian referral ECMO center. BMC Pulm Med. 2011;11:2.
Peris A, Cianchi G, Biondi S, Bonizzoli M, Pasquini A, Bonacchi M, Ciapetti M, Zagli G, Bacci S, Lazzeri C, Bernardo P, Mascitelli E, Sani G, Gensini GF. Extracorporeal life support for management of refractory cardiac or respiratory failure: initial experience in a tertiary centre. Scand J Trauma Resusc Emerg Med. 2010;18:28.
Fagnoul D, Pasquier P, Bodson L, Ortiz JA, Vincent JL, De Backer D. Myocardial dysfunction during H1N1 influenza infection. J Crit Care. 2013;28:321–7.
Jardin F, Fourme T, Page B, Loubières Y, Vieillard-Baron A, Beauchet A, Bourdarias JP. Persistent preload defect in severe sepsis despite fluid loading: a longitudinal echocardiographic study in patients with septic shock. Chest. 1999;116:1354–9.
Dolch ME, Frey L, Buerkle MA, Weig T, Wassilowsky D, Irlbeck M. Transesophageal echocardiography-guided technique for extracorporeal membrane oxygenation dual-lumen catheter placement. ASAIO J. 2011;57(4):341–3.
Flécher E, Anselmi A, Corbineau H, Langanay T, Verhoye JP, Félix C, Leurent G, Tulzo YL, Malledant Y, Leguerrier A. Current aspects of extracorporeal membrane oxygenation in a tertiary referral centre: determinants of survival at follow-up. Crit Care. 2011;15(5):R234.
Monsel A, Mal H, Brisson H, Luo R, Eyraud D, Vézinet C, Do CH, Lu Q, Vaillant JC, Hannoun L, Houssel P, Durand F, Rouby JJ. Extracorporeal membrane oxygenation as a bridge to liver transplantation for acute respiratory distress syndrome-induced life-threatening hypoxaemia aggravated by hepatopulmonary syndrome. Crit Care. 2011;15(5):R234.
Togo K, Takewa Y, Katagiri N, Fujii Y, Kishimoto S, Date K, Miyamoto Y, Tatsumi E.Impact of bypass flow rate and catheter position in veno-venous extracorporeal membrane oxygenation on gas exchange in vivo. J Artif Organs. 2014 [Epub ahead of print].
Javidfar J, Wang D, Zwischenberger J, Costa J, Mongero L, Sonett J, Bacchetta M. Insertion of bicaval dual lumen extracorporeal membrane oxygenation catheter with image guidance. ASAIO J. 2011;57:203–5.
Bermudez CA, Rocha RV, Sappington PL, Toyoda Y, Murray HN, Boujoukos AJ. Initial experience with single cannulation for venovenous extracorporeal oxygenation in adults. Ann Thorac Surg. 2010;90:991–5.
Chimot L, Marqué S, Gros A, Gacouin A, Lavoué S, Camus C, Le Tulzo Y. Avalon© bicaval dual-lumen cannula for venovenous extracorporeal membrane oxygenation: survey of cannula use in France. ASAIO J. 2013;59(2):157–61.
Dalmau MJ. Initiation of an inter-hospital ECMO transfer program for patients suffering from severe acute heart and/or pulmonary failure. Rev Esp Cardiol. 2014;67(4):324–30.
Lindskov C, Jensen RH, Sprogoe P, Klaaborg KE, Kirkegaard H, Severinsen IK, Lorentsen AG, Folkersen L, Ilkjaer S, Pedersen CM. Extracorporeal membrane oxygenation in adult patients with severe acute respiratory failure. Acta Anaesthesiol Scand. 2013;57:303–11.
Aubron C, Cheng AC, Pilcher D, Leong T, Magrin G, Cooper DJ, Scheinkestel C, Pellegrino V. Factors associated with outcomes of patients on extracorporeal membrane oxygenation support: a 5-year cohort study. Crit Care. 2013;17:R73.
Beurthereta S, Mastroiannia C, Pozzia M, D’Alessandro C, Luytd CE, Combes A, Pavie A, Leprincea P. Extracorporeal membrane oxygenation for 2009 influenza A (H1N1) acute respiratory distress syndrome: single-centre experience with 1-year follow-up. Eur J Cardiothorac Surg. 2012;41:691–5.
Starck CT, Hasenclever P, Falck V, Wilhelm MJ. Interhospital transfer of serious sick ARDS unsing venous-venous extracorporeal membrane oxygenation (ECMO): concept of an ECMO transport team. Int J crit Illn Inj Sci. 2013;13:46–50.
Combes A, Brodie D, Bartlett R, Brochard L, Brower R, Conrad S, De Backer D, Fan E, Ferguson N, Fortenberry J, Fraser J, Gattinoni L, Lynch W, MacLaren G, Mercat A, Mueller T, Ogino M, Peek G, Pellegrino V, Pesenti A, Ranieri M, Slutsky A, Vuylsteke A. The international ECMO network (ECMONet).Position paper for the organization of extracorporeal membrane oxygenation programs for acute respiratory failure in adult patients. Am J Respir Crit Care Med. 2014. [Epub ahead of print].
Ranasinghe AM, Peek GJ, Roberts N, Chin D, Killer HM, Sosnowski AW, Firmin RK. The use of transesophageal echocardiography to demonstrate obstruction of venous drainage cannula during ECMO. ASAIO J. 2004;50(6):619–20.
Hirose H, Yamane K, Gregary Marhefka G, Cavarocchi N. Right ventricular rupture and tamponade caused by malposition of the avalon cannula for venovenous extracorporeal membrane oxygenation. J Cardiothorac Surg. 2012;7(36):1–4.
Yastrebov K, Manganas C, Kapalli T, Peeceeyen S. Right ventricular loop indicating malposition of J-wire introducer for double lumen bicaval venovenous extracorporeal membrane oxygenation (VV ECMO) cannula. Heart Lung Circ. 2014;23:e4–7.
Shekar K, Mullany DV, Thomson B, Ziegenfuss M, Platts DG, Fraser JF. Extracorporeal life support devices and strategies for management of acute cardiorespiratory failure in adult patients: a comprehensive review. Crit Care. 2014;18(3):219 [Epub ahead of print].
Schmidt M1, Bailey M, Kelly J, Hodgson C, Cooper DJ, Scheinkestel C, Pellegrino V, Bellomo R, Pilcher D. Impact of fluid balance on outcome of adult patients treated with extracorporeal membrane oxygenation. Intensive Care Med. 2014. [Epub ahead of print].
Hayes D Jr, Preston TJ, McConnell PI, Galantowicz M, Yates AR. Bedside saline-contrast transthoracic echocardiography placement of bicaval dual-lumen catheter for venovenous extracorporeal membrane oxygenation. Am J Respir Crit Care Med. 2013;187(12):1395–6.
Ikonomidis I, Nikolaou M, Dimopoulou I, Paraskevaidis I, Lekakis J, Mavrou I, Tzanela M, Kopterides P, Tsangaris I, Armaganidis A, Kremastinos DT. Association of left ventricular diastolic dysfunction with elevated NT-pro-BNP in general intensive care unit patients with preserved ejection fraction: a complementary role of tissue Doppler imaging parameters and NT-pro-BNP levels for adverse outcome. Shock. 2010;33(2):141–8.
Cameli M, Bigio E, Lisi M, Righini FM, Galderisi M, Franchi F, Scolletta S, Mondillo S. Relationship between pulse pressure variation and echocardiographic indices of left ventricular filling pressure in critically ill patients. Clin Physiol Funct Imaging. 2014;. doi:10.1111/cpf.12168.
Ferrada P, Murthi S, Anand RJ, Bochicchio GV, Scalea T. Transthoracic focused rapid echocardiographic examination: real-time evaluation of fluid status in critically ill trauma patients. J Trauma. 2011;70(1):56–62.
Sturgess DJ, Marwick TH, Joyce C, Jenkins C, Jones M, Masci P, Stewart D, Venkatesh B. Prediction of hospital outcome in septic shock: a prospective comparison of tissue Doppler and cardiac biomarkers. Crit Care. 2010;14(2):R44. doi:10.1186/cc8931.
Lancellotti P, Price S, Edvardsen T, Cosyns B, Neskovic AN, Dulgheru R, Flachskampf FA, Hassager C, Pasquet A, Gargani L, Galderisi M, Cardim N, Haugaa KH, Ancion A, Zamorano JL, Donal E, Bueno H, Habib G.The use of echocardiography in acute cardiovascular care: Recommendations of the European Association of Cardiovascular Imaging and the Acute Cardiovascular Care Association.Eur Heart J Acute Cardiovasc Care. 2014. pii: 2048872614549739.
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Peris, A., Lazzeri, C., Cianchi, G. et al. Clinical significance of echocardiography in patients supported by venous–venous extracorporeal membrane oxygenation. J Artif Organs 18, 99–105 (2015). https://doi.org/10.1007/s10047-015-0824-2
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DOI: https://doi.org/10.1007/s10047-015-0824-2